Detail Information

Basic Information:


  VIRBase ID:  

VHID00514408

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           UTP23:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p UTP23
miRBase
Accession/Entrez ID		 MIMAT0001581 84294
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C8orf53

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UTP23
chr8:117804840(+) A-I      intronic
chr8:117800585(+) A-I      intronic
chr8:117800550(+) A-I      intronic
chr8:117781139(+) A-I      intronic
chr8:117825237(+) A-I      intronic
chr8:117800618(+) A-I      intronic
chr8:117809285(+) A-I      intronic
chr8:117792944(+) A-I      intronic
chr8:117780180(+) A-I      intronic
chr8:117800624(+) A-I      intronic
chr8:117788467(+) A-I      intronic
chr8:117851469(+) A-I      intronic
chr8:117794194(+) A-I      intronic
chr8:117839956(+) A-I      intronic
chr8:117838159(+) A-I      intronic
chr8:117794102(+) A-I      intronic
chr8:117839148(+) A-I      intronic
chr8:117842779(+) A-I      intronic
chr8:117800488(+) A-I      intronic
chr8:117780185(+) A-I      intronic
chr8:117825165(+) A-I      intronic
chr8:117803161(+) A-I      intronic
chr8:117826967(+) A-I      intronic
chr8:117781178(+) A-I      intronic
chr8:117800551(+) A-I      intronic
chr8:117800678(+) A-I      intronic
chr8:117788517(+) A-I      intronic
chr8:117799884(+) A-I      intronic
chr8:117787199(+) A-I      intronic
chr8:117788924(+) A-I      intronic
chr8:117782959(+) A-I      intronic
chr8:117804977(+) A-I      intronic
chr8:117800538(+) A-I      intronic
chr8:117794244(+) A-I      intronic
chr8:117850535(+) A-I      intronic
chr8:117800473(+) A-I      intronic
chr8:117804911(+) A-I      intronic
chr8:117794870(+) A-I      intronic
chr8:117782914(+) A-I      intronic
chr8:117839115(+) A-I      intronic
chr8:117839291(+) A-I      intronic
chr8:117788401(+) A-I      intronic
chr8:117794182(+) A-I      intronic
chr8:117794116(+) A-I      intronic
chr8:117851488(+) A-I      intronic
chr8:117839195(+) A-I      intronic
chr8:117794112(+) A-I      intronic
chr8:117793032(+) A-I      intronic
chr8:117794828(+) A-I      intronic
chr8:117825164(+) A-I      intronic
chr8:117780232(+) A-I      intronic
chr8:117792866(+) A-I      intronic
chr8:117850548(+) A-I      intronic
chr8:117794062(+) A-I      intronic
chr8:117799887(+) A-I      intronic
chr8:117845142(+) A-I      intronic
chr8:117800527(+) A-I      intronic
chr8:117793087(+) A-I      intronic
chr8:117800487(+) A-I      intronic
chr8:117794044(+) A-I      intronic
chr8:117800541(+) A-I      intronic
chr8:117780279(+) A-I      intronic
chr8:117792909(+) A-I      intronic
chr8:117794183(+) A-I      intronic
chr8:117794923(+) A-I      intronic
chr8:117823635(+) A-I      intronic
chr8:117806073(+) A-I      intronic
chr8:117805945(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UTP23
chr8:117780185(+) A-G intron -    22484847
chr8:117784241(+) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UTP23
chr8:117778759-117778760(+) m6A 5'UTR       24981863
chr8:117778862-117778863(+) m6A CDS//exon       24981863
chr8:117782393-117782394(+) m6A exon//intron       24981863
chr8:117783758-117783759(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783773-117783774(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783790-117783791(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783858-117783859(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783873-117783874(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783890-117783891(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783897-117783898(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:117783977-117783978(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:117784028-117784029(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:117784102-117784103(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:117784155-117784156(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr8:117784160-117784161(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr8:117784178-117784179(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr8:117784216-117784217(+) m6A 3'UTR//intron       24981863//22608085
chr8:117784245-117784246(+) m6A 3'UTR//intron       24981863//22608085
chr8:117798868-117798869(+) m6A 3'UTR//intron       22608085
chr8:117798912-117798913(+) m6A 3'UTR//intron       22608085
chr8:117861129-117861130(+) m6A 3'UTR//CDS       22608085
chr8:117861168-117861169(+) m6A 3'UTR//CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr8:117861190-117861191(+) m6A 3'UTR//CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr8:117861301-117861302(+) m6A 3'UTR       25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr8:117861376-117861377(+) m6A 3'UTR       27773535//27371828
chr8:117861387-117861388(+) m6A 3'UTR       27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate UTP23
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: UTP23

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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