Detail Information

Basic Information:


  VIRBase ID:  

VHID00514243

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           STK40:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p STK40
miRBase
Accession/Entrez ID		 MIMAT0001581 83931
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - SgK495//SHIK

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STK40
chr1:36842537(-) A-I      intronic
chr1:36834012(-) A-I      intronic
chr1:36848621(-) A-I      intronic
chr1:36834020(-) A-I      intronic
chr1:36834048(-) A-I      intronic
chr1:36834052(-) A-I      intronic
chr1:36848610(-) A-I      intronic
chr1:36848617(-) A-I      intronic
chr1:36848618(-) A-I      intronic
chr1:36848633(-) A-I      intronic
chr1:36848647(-) A-I      intronic
chr1:36848719(-) A-I      intronic
chr1:36848722(-) A-I      intronic
chr1:36848726(-) A-I      intronic
chr1:36848728(-) A-I      intronic
chr1:36848731(-) A-I      intronic
chr1:36848742(-) A-I      intronic
chr1:36848750(-) A-I      intronic
chr1:36848752(-) A-I      intronic
chr1:36848794(-) A-I      intronic
chr1:36848764(-) A-I      intronic
chr1:36848674(-) A-I      intronic
chr1:36847999(-) A-I      intronic
chr1:36847963(-) A-I      intronic
chr1:36847960(-) A-I      intronic
chr1:36847823(-) A-I      intronic
chr1:36844127(-) A-I      intronic
chr1:36844107(-) A-I      intronic
chr1:36843126(-) A-I      intronic
chr1:36843058(-) A-I      intronic
chr1:36830695(-) A-I      intronic
chr1:36830368(-) A-I      intronic
chr1:36830342(-) A-I      intronic
chr1:36828827(-) A-I      intronic
chr1:36828625(-) A-I      intronic
chr1:36823387(-) A-I      intronic
chr1:36843048(-) A-I      intronic
chr1:36843071(-) A-I      intronic
chr1:36842968(-) A-I      intronic
chr1:36842587(-) A-I      intronic
chr1:36842578(-) A-I      intronic
chr1:36842575(-) A-I      intronic
chr1:36842552(-) A-I      intronic
chr1:36843072(-) A-I      intronic
chr1:36842551(-) A-I      intronic
chr1:36841459(-) A-I      intronic
chr1:36841456(-) A-I      intronic
chr1:36841387(-) A-I      intronic
chr1:36837239(-) A-I      intronic
chr1:36837093(-) A-I      intronic
chr1:36837092(-) A-I      intronic
chr1:36837033(-) A-I      intronic
chr1:36830720(-) A-I      intronic
chr1:36830698(-) A-I      intronic
chr1:36843012(-) A-I      intronic
chr1:36843010(-) A-I      intronic
chr1:36843005(-) A-I      intronic
chr1:36843022(-) A-I      intronic
chr1:36837910(-) A-I      intronic
chr1:36830768(-) A-I      intronic
chr1:36837994(-) A-I      intronic
chr1:36842644(-) A-I      intronic
chr1:36837962(-) A-I      intronic
chr1:36828635(-) A-I      intronic
chr1:36826147(-) A-I      intronic
chr1:36829218(-) A-I      intronic
chr1:36842577(-) A-I      intronic
chr1:36832501(-) A-I      intronic
chr1:36842942(-) A-I      intronic
chr1:36826179(-) A-I      intronic
chr1:36830795(-) A-I      intronic
chr1:36837839(-) A-I      intronic
chr1:36826174(-) A-I      intronic
chr1:36848687(-) A-I      intronic
chr1:36844330(-) A-I      intronic
chr1:36849746(-) A-I      intronic
chr1:36812049(-) A-I      intronic
chr1:36843850(-) A-I      intronic
chr1:36830730(-) A-I      intronic
chr1:36837840(-) A-I      intronic
chr1:36842514(-) A-I      intronic
chr1:36842456(-) A-I      intronic
chr1:36842505(-) A-I      intronic
chr1:36836615(-) A-I      intronic
chr1:36842517(-) A-I      intronic
chr1:36846155(-) A-I      intronic
chr1:36830766(-) A-I      intronic
chr1:36830704(-) A-I      intronic
chr1:36847147(-) A-I      intronic
chr1:36828817(-) A-I      intronic
chr1:36836899(-) A-I      intronic
chr1:36828821(-) A-I      intronic
chr1:36834061(-) A-I      intronic
chr1:36828704(-) A-I      intronic
chr1:36848688(-) A-I      intronic
chr1:36828608(-) A-I      intronic
chr1:36842453(-) A-I      intronic
chr1:36830729(-) A-I      intronic
chr1:36842582(-) A-I      intronic
chr1:36813257(-) A-I      intronic
chr1:36830863(-) A-I      intronic
chr1:36847363(-) A-I      intronic
chr1:36826153(-) A-I      intronic
chr1:36849727(-) A-I      intronic
chr1:36829294(-) A-I      intronic
chr1:36836703(-) A-I      intronic
chr1:36847362(-) A-I      intronic
chr1:36847289(-) A-I      intronic
chr1:36847154(-) A-I      intronic
chr1:36826416(-) A-I      intronic
chr1:36844239(-) A-I      intronic
chr1:36836117(-) A-I      intronic
chr1:36837914(-) A-I      intronic
chr1:36828822(-) A-I      intronic
chr1:36844331(-) A-I      intronic
chr1:36842917(-) A-I      intronic
chr1:36830395(-) A-I      intronic
chr1:36847227(-) A-I      intronic
chr1:36832573(-) A-I      intronic
chr1:36847864(-) A-I      intronic
chr1:36836574(-) A-I      intronic
chr1:36830689(-) A-I      intronic
chr1:36828867(-) A-I      intronic
chr1:36826239(-) A-I      intronic
chr1:36837822(-) A-I      intronic
chr1:36847243(-) A-I      intronic
chr1:36829496(-) A-I      intronic
chr1:36842515(-) A-I      intronic
chr1:36842645(-) A-I      intronic
chr1:36844339(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STK40
chr1:36828608(-) A-G intron -    22484847
chr1:36829218(-) A-G intron -    22484847
chr1:36829294(-) A-G intron -    22484847
chr1:36830730(-) A-G intron -    22484847
chr1:36836574(-) A-G intron -    22484847
chr1:36842453(-) A-G intron -    22484847
chr1:36842456(-) A-G intron -    22484847
chr1:36842514(-) A-G intron -    22484847
chr1:36842515(-) A-G intron -    22484847
chr1:36842517(-) A-G intron -    22484847
chr1:36842577(-) A-G intron -    22484847
chr1:36842582(-) A-G intron -    22484847
chr1:36842644(-) A-G intron -    22484847
chr1:36842645(-) A-G intron -    22484847
chr1:36842942(-) A-G intron -    22484847
chr1:36843081(-) G-A intron -    22484847
chr1:36843091(-) C-A intron -    22484847
chr1:36847940(-) G-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STK40
chr1:36805926-36805927(-) m6A 3'UTR       24284625//27773535
chr1:36806121-36806122(-) m6A 3'UTR       24284625//24981863//27773535
chr1:36806149-36806150(-) m6A 3'UTR       24284625//24981863//27773535
chr1:36806249-36806250(-) m6A 3'UTR       24284625//27773535
chr1:36806271-36806272(-) m6A 3'UTR       24284625//27773535
chr1:36806298-36806299(-) m6A 3'UTR       24284625//27773535
chr1:36806330-36806331(-) m6A 3'UTR       27773535
chr1:36806381-36806382(-) m6A 3'UTR       24284625
chr1:36806486-36806487(-) m6A 3'UTR       27773535
chr1:36806590-36806591(-) m6A 3'UTR       27773535
chr1:36806721-36806722(-) m6A 3'UTR       24284625//24981863//27773535
chr1:36806813-36806814(-) m6A 3'UTR       24981863//27773535
chr1:36806818-36806819(-) m6A 3'UTR       24981863//27773535
chr1:36806836-36806837(-) m6A 3'UTR       24981863//27773535
chr1:36807226-36807227(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr1:36807232-36807233(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr1:36807243-36807244(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr1:36807265-36807266(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr1:36807392-36807393(-) m6A 3'UTR//CDS       24284625
chr1:36814344-36814345(-) m6A CDS       27773535
chr1:36814356-36814357(-) m6A CDS       27773535
chr1:36819982-36819983(-) m6A CDS       27773535
chr1:36819997-36819998(-) m6A CDS       27773535
chr1:36820856-36820857(-) m6A CDS//exon       27773535
chr1:36820919-36820920(-) m6A CDS//exon       27773535
chr1:36820951-36820952(-) m6A CDS//exon       27773535
chr1:36821008-36821009(-) m6A CDS//exon       27773535
chr1:36823957-36823958(-) m6A CDS//exon       27371828
chr1:36826834-36826835(-) m6A CDS//exon       24209618//27371828
chr1:36826913-36826914(-) m6A CDS//exon       24209618//27371828//27773536
chr1:36828218-36828219(-) m6A exon//intron       27371828//27773536
chr1:36828253-36828254(-) m6A exon//intron       27371828
chr1:36833487-36833488(-) m6A 5'UTR//exon//intron       27773535
chr1:36833509-36833510(-) m6A 5'UTR//exon//intron       27773535
chr1:36833558-36833559(-) m6A 5'UTR//exon//intron       24284625//27773535
chr1:36851356-36851357(-) m6A 5'UTR//exon       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate STK40
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: STK40

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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