Basic Information:

  VIRBase ID:  

VHID00514104

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SH3BGRL3:  NM_031286     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SH3BGRL3
miRBase Accession/Entrez ID	MIMAT0001581	83442
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-297//SH3BP-1//TIP-B1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH3BGRL3	chr1:26606552-26606553(+) m6A 5'UTR//CDS       24981863 chr1:26607322-26607323(+) m6A CDS       24284625//22575960 chr1:26607334-26607335(+) m6A CDS       24284625//22575960 chr1:26607409-26607410(+) m6A CDS       24284625//22575960 chr1:26607467-26607468(+) m6A CDS//intron       24284625//24981863 chr1:26607549-26607550(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960 chr1:26607577-26607578(+) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22575960 chr1:26607582-26607583(+) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22575960 chr1:26607643-26607644(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960 chr1:26607687-26607688(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SH3BGRL3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SH3BGRL3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.