Basic Information:

  VIRBase ID:  

VHID00514064

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLCO5A1:  NM_030958     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLCO5A1
miRBase Accession/Entrez ID	MIMAT0001581	81796
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	OATP-J//OATP-RP4//OATP5A1//OATPJ//OATPRP4//SLC21A15

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLCO5A1	chr8:70644949(-) A-I      intronic chr8:70668578(-) A-I      intronic chr8:70733511(-) A-I      intronic chr8:70587668(-) A-I      intronic chr8:70587574(-) A-I      intronic chr8:70636281(-) A-I      intronic chr8:70641490(-) A-I      intronic chr8:70641512(-) A-I      intronic chr8:70641635(-) A-I      intronic chr8:70641641(-) A-I      intronic chr8:70670578(-) A-I      intronic chr8:70645002(-) A-I      intronic chr8:70645041(-) A-I      intronic chr8:70663957(-) A-I      intronic chr8:70664014(-) A-I      intronic chr8:70664365(-) A-I      intronic chr8:70668460(-) A-I      intronic chr8:70668474(-) A-I      intronic chr8:70668483(-) A-I      intronic chr8:70674546(-) A-I      intronic chr8:70674624(-) A-I      intronic chr8:70675353(-) A-I      intronic chr8:70675372(-) A-I      intronic chr8:70675435(-) A-I      intronic chr8:70676168(-) A-I      intronic chr8:70676185(-) A-I      intronic chr8:70676295(-) A-I      intronic chr8:70683344(-) A-I      intronic chr8:70683438(-) A-I      intronic chr8:70688141(-) A-I      intronic chr8:70694021(-) A-I      intronic chr8:70694093(-) A-I      intronic chr8:70705397(-) A-I      intronic chr8:70705398(-) A-I      intronic chr8:70715570(-) A-I      intronic chr8:70716823(-) A-I      intronic chr8:70720067(-) A-I      intronic chr8:70720077(-) A-I      intronic chr8:70721135(-) A-I      intronic chr8:70721174(-) A-I      intronic chr8:70721183(-) A-I      intronic chr8:70721331(-) A-I      intronic chr8:70740718(-) A-I      intronic chr8:70740725(-) A-I      intronic chr8:70741905(-) A-I      intronic chr8:70675428(-) A-I      intronic chr8:70634362(-) A-I      intronic chr8:70634368(-) A-I      intronic chr8:70636104(-) A-I      intronic chr8:70634172(-) A-I      intronic chr8:70634279(-) A-I      intronic chr8:70615141(-) A-I      intronic chr8:70634350(-) A-I      intronic chr8:70634355(-) A-I      intronic chr8:70587506(-) A-I      intronic chr8:70634298(-) A-I      intronic chr8:70636136(-) A-I      intronic chr8:70636258(-) A-I      intronic chr8:70587507(-) A-I      intronic chr8:70636152(-) A-I      intronic chr8:70587625(-) A-I      intronic chr8:70636264(-) A-I      intronic chr8:70664223(-) A-I      intronic chr8:70683423(-) A-I      intronic chr8:70638820(-) A-I      intronic chr8:70664207(-) A-I      intronic chr8:70644944(-) A-I      intronic chr8:70668557(-) A-I      intronic chr8:70676294(-) A-I      intronic chr8:70705385(-) A-I      intronic chr8:70587547(-) A-I      intronic chr8:70664384(-) A-I      intronic chr8:70638899(-) A-I      intronic chr8:70683392(-) A-I      intronic chr8:70664231(-) A-I      intronic chr8:70587538(-) A-I      intronic chr8:70664286(-) A-I      intronic chr8:70622481(-) A-I      intronic chr8:70664033(-) A-I      intronic chr8:70664383(-) A-I      intronic chr8:70670537(-) A-I      intronic chr8:70682586(-) A-I      intronic chr8:70664041(-) A-I      intronic chr8:70655610(-) A-I      intronic chr8:70716677(-) A-I      intronic chr8:70694060(-) A-I      intronic chr8:70634234(-) A-I      intronic chr8:70705951(-) A-I      intronic chr8:70670688(-) A-I      intronic chr8:70666042(-) A-I      intronic chr8:70635560(-) A-I      intronic chr8:70694632(-) A-I      intronic chr8:70670634(-) A-I      intronic chr8:70639017(-) A-I      intronic chr8:70668393(-) A-I      intronic chr8:70638831(-) A-I      intronic chr8:70622535(-) A-I      intronic chr8:70715576(-) A-I      intronic chr8:70716842(-) A-I      intronic chr8:70668577(-) A-I      intronic chr8:70683384(-) A-I      intronic chr8:70721287(-) A-I      intronic chr8:70668400(-) A-I      intronic chr8:70705396(-) A-I      intronic chr8:70721335(-) A-I      intronic chr8:70670560(-) A-I      intronic chr8:70668402(-) A-I      intronic chr8:70683437(-) A-I      intronic chr8:70716745(-) A-I      intronic chr8:70675693(-) A-I      intronic chr8:70587615(-) A-I      intronic chr8:70715540(-) A-I      intronic chr8:70721177(-) A-I      intronic chr8:70702753(-) A-I      intronic chr8:70676303(-) A-I      intronic chr8:70720071(-) A-I      intronic chr8:70668563(-) A-I      intronic chr8:70705314(-) A-I      intronic chr8:70587153(-) A-I      intronic chr8:70664077(-) A-I      intronic chr8:70705412(-) A-I      intronic chr8:70636036(-) A-I      intronic chr8:70716815(-) A-I      intronic chr8:70716686(-) A-I      intronic chr8:70619220(-) A-I      intronic chr8:70619261(-) A-I      intronic chr8:70682612(-) A-I      intronic chr8:70664404(-) A-I      intronic chr8:70676293(-) A-I      intronic chr8:70715352(-) A-I      intronic chr8:70721227(-) A-I      intronic chr8:70663958(-) A-I      intronic chr8:70664397(-) A-I      intronic chr8:70616368(-) A-I      intronic chr8:70721256(-) A-I      intronic chr8:70587639(-) A-I      intronic chr8:70721083(-) A-I      intronic chr8:70705950(-) A-I      intronic chr8:70720218(-) A-I      intronic chr8:70636132(-) A-I      intronic chr8:70663850(-) A-I      intronic chr8:70587223(-) A-I      intronic chr8:70705423(-) A-I      intronic chr8:70668540(-) A-I      intronic chr8:70587534(-) A-I      intronic chr8:70676296(-) A-I      intronic chr8:70668437(-) A-I      intronic chr8:70635611(-) A-I      intronic chr8:70619195(-) A-I      intronic chr8:70670543(-) A-I      intronic chr8:70668564(-) A-I      intronic chr8:70607674(-) A-I      intronic chr8:70622418(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLCO5A1	chr8:70663958(-) A-I intron -    22327324 chr8:70602536(-) A-G intron -    21725310 chr8:70587193(-) A-G intron -    22484847 chr8:70587534(-) A-G intron -    22484847 chr8:70587538(-) A-G intron -    22484847 chr8:70587639(-) A-G intron -    22484847 chr8:70595977(-) G-A intron -    22484847 chr8:70607674(-) A-G intron -    22484847 chr8:70609574(-) C-T intron -    22484847 chr8:70616385(-) C-G intron -    22484847 chr8:70616429(-) T-G intron -    22484847 chr8:70619195(-) A-G intron -    22484847 chr8:70619220(-) A-G intron -    22484847 chr8:70619261(-) A-G intron -    22484847 chr8:70622481(-) A-G intron -    22484847 chr8:70636132(-) A-G intron -    22484847 chr8:70638820(-) A-G intron -    22484847 chr8:70638872(-) A-G intron -    22484847 chr8:70639017(-) A-G intron -    22484847 chr8:70644944(-) A-G intron -    22484847 chr8:70663850(-) A-G intron -    22484847 chr8:70663878(-) A-G intron -    22484847 chr8:70663958(-) A-G intron -    22484847 chr8:70664033(-) A-G intron -    22484847 chr8:70664041(-) A-G intron -    22484847 chr8:70664077(-) A-G intron -    22484847 chr8:70664286(-) A-G intron -    22484847 chr8:70664383(-) A-G intron -    22484847 chr8:70664384(-) A-G intron -    22484847 chr8:70664397(-) A-G intron -    22484847 chr8:70664398(-) A-G intron -    22484847 chr8:70664404(-) A-G intron -    22484847 chr8:70664460(-) A-G intron -    22484847 chr8:70668402(-) A-G intron -    22484847 chr8:70668437(-) A-G intron -    22484847 chr8:70668468(-) A-G intron -    22484847 chr8:70668477(-) A-G intron -    22484847 chr8:70668540(-) A-G intron -    22484847 chr8:70668557(-) A-G intron -    22484847 chr8:70668563(-) A-G intron -    22484847 chr8:70668564(-) A-G intron -    22484847 chr8:70668577(-) A-G intron -    22484847 chr8:70668639(-) A-G intron -    22484847 chr8:70669831(-) A-G intron -    22484847 chr8:70670435(-) G-A intron -    22484847 chr8:70670524(-) A-G intron -    22484847 chr8:70670537(-) A-G intron -    22484847 chr8:70670543(-) A-G intron -    22484847 chr8:70670560(-) A-G intron -    22484847 chr8:70670614(-) A-G intron -    22484847 chr8:70670633(-) A-G intron -    22484847 chr8:70670634(-) A-G intron -    22484847 chr8:70670688(-) A-G intron -    22484847 chr8:70670696(-) A-G intron -    22484847 chr8:70672112(-) T-C intron -    22484847 chr8:70676293(-) A-G intron -    22484847 chr8:70676294(-) A-G intron -    22484847 chr8:70676296(-) A-G intron -    22484847 chr8:70676303(-) A-G intron -    22484847 chr8:70680124(-) G-T intron -    22484847 chr8:70682612(-) A-G intron -    22484847 chr8:70683423(-) A-G intron -    22484847 chr8:70683437(-) A-G intron -    22484847 chr8:70694060(-) A-G intron -    22484847 chr8:70705314(-) A-G intron -    22484847 chr8:70705401(-) A-G intron -    22484847 chr8:70705412(-) A-G intron -    22484847 chr8:70705423(-) A-G intron -    22484847 chr8:70705754(-) A-G intron -    22484847 chr8:70705950(-) A-G intron -    22484847 chr8:70705951(-) A-G intron -    22484847 chr8:70705956(-) A-G intron -    22484847 chr8:70715540(-) A-G intron -    22484847 chr8:70715569(-) A-G intron -    22484847 chr8:70715576(-) A-G intron -    22484847 chr8:70716677(-) A-G intron -    22484847 chr8:70716681(-) A-G intron -    22484847 chr8:70716686(-) A-G intron -    22484847 chr8:70716815(-) A-G intron -    22484847 chr8:70716824(-) A-G intron -    22484847 chr8:70716842(-) A-G intron -    22484847 chr8:70720071(-) A-G intron -    22484847 chr8:70721177(-) A-G intron -    22484847 chr8:70721227(-) A-G intron -    22484847 chr8:70721256(-) A-G intron -    22484847 chr8:70721287(-) A-G intron -    22484847 chr8:70742674(-) A-G intron -    22484847 chr8:70742701(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLCO5A1	chr8:70584699-70584700(-) m6A 3'UTR       25456834//24981863//22608085 chr8:70584734-70584735(-) m6A 3'UTR       25456834//24981863//22608085 chr8:70584755-70584756(-) m6A 3'UTR       25456834//24981863//22608085 chr8:70584802-70584803(-) m6A 3'UTR       25456834//24981863//22608085 chr8:70584927-70584928(-) m6A 3'UTR       24981863//22608085 chr8:70584976-70584977(-) m6A 3'UTR       24981863//22608085 chr8:70584985-70584986(-) m6A 3'UTR       24981863//22608085 chr8:70584998-70584999(-) m6A 3'UTR       24981863//22608085 chr8:70585044-70585045(-) m6A 3'UTR       24981863//22608085 chr8:70585149-70585150(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//22608085 chr8:70585192-70585193(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//27773536//22608085 chr8:70585228-70585229(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//27371828//27773536//22608085 chr8:70585276-70585277(-) m6A 3'UTR//CDS       25456834//24981863//28052920//27371828//27773536//22608085 chr8:70585295-70585296(-) m6A 3'UTR//CDS       25456834//24981863//28052920//27773536//22608085 chr8:70585352-70585353(-) m6A 3'UTR//CDS       25456834//24981863//28052920//22608085 chr8:70602318-70602319(-) Y intron       16381836 chr8:70602333-70602334(-) Gm intron       16381836 chr8:70602357-70602358(-) Y intron       16381836 chr8:70602378-70602379(-) Gm intron       16381836 chr8:70602390-70602391(-) Cm intron       16381836 chr8:70602393-70602394(-) Y intron       16381836//25192136 chr8:70602408-70602409(-) Cm intron       16381836 chr8:70602410-70602411(-) Am intron       16381836 chr8:70602418-70602419(-) Gm intron       16381836 chr8:70602424-70602425(-) Y intron       16381836//25192136 chr8:70602426-70602427(-) Y intron       16381836//25192136 chr8:70602433-70602434(-) Y intron       16381836//25192136 chr8:70602436-70602437(-) Cm intron       16381836 chr8:70602447-70602448(-) Am intron       16381836 chr8:70602452-70602453(-) Am intron       16381836 chr8:70602455-70602456(-) Y intron       16381836//25192136 chr8:70602459-70602460(-) Um intron       16381836 chr8:70602459-70602460(-) Y intron       16381836//25192136 chr8:70602469-70602470(-) Cm intron       16381836 chr8:70602492-70602493(-) Am intron       16381836 chr8:70602507-70602508(-) Y intron       16381836 chr8:70602509-70602510(-) Y intron       16381836 chr8:70602517-70602518(-) Am intron       16381836 chr8:70602582-70602583(-) Y intron       16381836//25192136 chr8:70744018-70744019(-) m6A CDS//exon       - chr8:70744053-70744054(-) m6A CDS//exon       22608085 chr8:70744147-70744148(-) m6A CDS//exon       22608085 chr8:70744302-70744303(-) m6A CDS//exon       - chr8:70744375-70744376(-) m6A CDS//exon       22608085 chr8:70744598-70744599(-) m6A CDS//exon       27773536 chr8:70744609-70744610(-) m6A CDS//exon       27773536 chr8:70744627-70744628(-) m6A CDS//exon       27773536 chr8:70744814-70744815(-) m6A CDS//exon       25456834//22608085 chr8:70744890-70744891(-) m6A CDS//exon       25456834//24981863//22608085 chr8:70745002-70745003(-) m6A 5'UTR//exon       24209618//25456834//22608085 chr8:70745139-70745140(-) m6A 5'UTR//exon       25456834//27773536//22608085 chr8:70745317-70745318(-) m6A 5'UTR//exon       27773536 chr8:70745359-70745360(-) m6A 5'UTR//exon       - chr8:70747095-70747096(-) m6A 5'UTR//exon       - chr8:70747107-70747108(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLCO5A1	Chromatin HeLa-S3 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLCO5A1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.