Basic Information:

  VIRBase ID:  

VHID00514012

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TXNDC5:  NM_022085     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TXNDC5
miRBase Accession/Entrez ID	MIMAT0001581	81567
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ENDOPDI//ERP46//HCC-2//HCC2//PDIA15//STRF8//UNQ364

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TXNDC5	chr6:7882611-7882612(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882658-7882659(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882867-7882868(-) m6A 3'UTR//exon       26404942//22575960 chr6:7883049-7883050(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883083-7883084(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883149-7883150(-) m6A 3'UTR//exon       24284625//24981863 chr6:7883267-7883268(-) m6A 3'UTR//exon       24284625 chr6:7883373-7883374(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960 chr6:7883382-7883383(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7883428-7883429(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7884628-7884629(-) m6A CDS//exon       24284625//22575960 chr6:7884681-7884682(-) m6A CDS//exon       22575960 chr6:7884704-7884705(-) m6A CDS//exon       22575960 chr6:7888990-7888991(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889005-7889006(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889113-7889114(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889125-7889126(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889184-7889185(-) m6A exon//intron       27773536 chr6:7889437-7889438(-) m6A exon//intron       24284625 chr6:7889453-7889454(-) m6A exon//intron       24284625 chr6:7889459-7889460(-) m6A exon//intron       24284625 chr6:7889776-7889777(-) m6A CDS       27773536//22575960//22608085 chr6:7889790-7889791(-) m6A CDS       27773536//22575960 chr6:7891870-7891871(-) m6A CDS       22575960 chr6:7891880-7891881(-) m6A CDS       22575960 chr6:7895414-7895415(-) m6A CDS//exon       27773535//22575960 chr6:7898846-7898847(-) Gm intron       - chr6:7899828-7899829(-) m6A CDS//exon       27773535//22575960 chr6:7899842-7899843(-) m6A CDS//exon       27773535//22575960 chr6:7899852-7899853(-) m6A CDS//exon       27773535//22575960 chr6:7899860-7899861(-) m6A CDS//exon       27773535//22575960 chr6:7899957-7899958(-) m6A exon//intron       27773535 chr6:7904860-7904861(-) m6A CDS       26404942//27773535//22575960 chr6:7904898-7904899(-) Cm 5'UTR//CDS       - chr6:7904908-7904909(-) m6A 5'UTR//CDS       26404942//27773535//22575960 chr6:7904949-7904950(-) m6A 5'UTR//CDS       24284625//24209618//27773535//22575960 chr6:7910054-7910055(-) m6A 5'UTR//intron       24284625//24209618//22575960 chr6:7910102-7910103(-) m6A 5'UTR//intron       24284625//24209618//27773536 chr6:7910197-7910198(-) m6A 5'UTR//intron       24209618//27773536 chr6:7910833-7910834(-) m6A CDS       24284625//24209618//27371828//27773536//22575960 chr6:7910838-7910839(-) m6A CDS       24284625//24209618//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TXNDC5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TXNDC5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.