Basic Information:

  VIRBase ID:  

VHID00513952

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LNPK:  NM_001305009     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LNPK
miRBase Accession/Entrez ID	MIMAT0001581	80856
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1715//LNP//LNP1//NEDEHCC//Ul//ulnaless

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LNPK	chr2:176816566(-) A-I      intronic chr2:176790487(-) A-I      3'UTR chr2:176860646(-) A-I      intronic chr2:176816567(-) A-I      intronic chr2:176790469(-) A-I      3'UTR chr2:176790450(-) A-I      3'UTR chr2:176790440(-) A-I      3'UTR chr2:176816571(-) A-I      intronic chr2:176860665(-) A-I      intronic chr2:176816559(-) A-I      intronic chr2:176860673(-) A-I      intronic chr2:176860685(-) A-I      intronic chr2:176790431(-) A-I      3'UTR chr2:176850224(-) A-I      intronic chr2:176850191(-) A-I      intronic chr2:176790427(-) A-I      3'UTR chr2:176789507(-) A-I      3'UTR chr2:176850185(-) A-I      intronic chr2:176850184(-) A-I      intronic chr2:176860695(-) A-I      intronic chr2:176850220(-) A-I      intronic chr2:176850186(-) A-I      intronic chr2:176850221(-) A-I      intronic chr2:176860625(-) A-I      intronic chr2:176810147(-) A-I      intronic chr2:176809840(-) A-I      intronic chr2:176809820(-) A-I      intronic chr2:176809809(-) A-I      intronic chr2:176809802(-) A-I      intronic chr2:176848210(-) A-I      intronic chr2:176809798(-) A-I      intronic chr2:176809797(-) A-I      intronic chr2:176789473(-) A-I      3'UTR chr2:176791158(-) A-I      3'UTR chr2:176850201(-) A-I      intronic chr2:176850225(-) A-I      intronic chr2:176860627(-) A-I      intronic chr2:176860639(-) A-I      intronic chr2:176816562(-) A-I      intronic chr2:176790501(-) A-I      3'UTR chr2:176790490(-) A-I      3'UTR chr2:176791207(-) A-I      3'UTR chr2:176791216(-) A-I      3'UTR chr2:176791220(-) A-I      3'UTR chr2:176864767(-) A-I      intronic chr2:176863050(-) A-I      intronic chr2:176862915(-) A-I      intronic chr2:176862646(-) A-I      intronic chr2:176862561(-) A-I      intronic chr2:176860740(-) A-I      intronic chr2:176860573(-) A-I      intronic chr2:176858421(-) A-I      intronic chr2:176858396(-) A-I      intronic chr2:176853770(-) A-I      intronic chr2:176853740(-) A-I      intronic chr2:176853732(-) A-I      intronic chr2:176853708(-) A-I      intronic chr2:176853701(-) A-I      intronic chr2:176853670(-) A-I      intronic chr2:176852951(-) A-I      intronic chr2:176845535(-) A-I      intronic chr2:176845526(-) A-I      intronic chr2:176845443(-) A-I      intronic chr2:176836915(-) A-I      intronic chr2:176836895(-) A-I      intronic chr2:176833614(-) A-I      intronic chr2:176810121(-) A-I      intronic chr2:176810109(-) A-I      intronic chr2:176810098(-) A-I      intronic chr2:176810085(-) A-I      intronic chr2:176810076(-) A-I      intronic chr2:176809908(-) A-I      intronic chr2:176809869(-) A-I      intronic chr2:176809748(-) A-I      intronic chr2:176864766(-) A-I      intronic chr2:176863085(-) A-I      intronic chr2:176863084(-) A-I      intronic chr2:176809738(-) A-I      intronic chr2:176809791(-) A-I      intronic chr2:176810146(-) A-I      intronic chr2:176853128(-) A-I      intronic chr2:176853201(-) A-I      intronic chr2:176809900(-) A-I      intronic chr2:176853158(-) A-I      intronic chr2:176810101(-) A-I      intronic chr2:176809755(-) A-I      intronic chr2:176830930(-) A-I      intronic chr2:176809899(-) A-I      intronic chr2:176859343(-) A-I      intronic chr2:176810070(-) A-I      intronic chr2:176809806(-) A-I      intronic chr2:176810111(-) A-I      intronic chr2:176830970(-) A-I      intronic chr2:176852973(-) A-I      intronic chr2:176809723(-) A-I      intronic chr2:176858434(-) A-I      intronic chr2:176853598(-) A-I      intronic chr2:176853599(-) A-I      intronic chr2:176810084(-) A-I      intronic chr2:176809979(-) A-I      intronic chr2:176862536(-) A-I      intronic chr2:176809805(-) A-I      intronic chr2:176859828(-) A-I      intronic chr2:176810133(-) A-I      intronic chr2:176862531(-) A-I      intronic chr2:176809845(-) A-I      intronic chr2:176833597(-) A-I      intronic chr2:176809804(-) A-I      intronic chr2:176809724(-) A-I      intronic chr2:176810171(-) A-I      intronic chr2:176809981(-) A-I      intronic chr2:176809993(-) A-I      intronic chr2:176809732(-) A-I      intronic chr2:176810170(-) A-I      intronic chr2:176860679(-) A-I      intronic chr2:176836732(-) A-I      intronic chr2:176810095(-) A-I      intronic chr2:176853775(-) A-I      intronic chr2:176863007(-) A-I      intronic chr2:176809883(-) A-I      intronic chr2:176862746(-) A-I      intronic chr2:176859827(-) A-I      intronic chr2:176852985(-) A-I      intronic chr2:176810008(-) A-I      intronic chr2:176862634(-) A-I      intronic chr2:176862682(-) A-I      intronic chr2:176853091(-) A-I      intronic chr2:176810035(-) A-I      intronic chr2:176809994(-) A-I      intronic chr2:176853157(-) A-I      intronic chr2:176798690(-) A-I      intronic chr2:176810046(-) A-I      intronic chr2:176858312(-) A-I      intronic chr2:176810151(-) A-I      intronic chr2:176853737(-) A-I      intronic chr2:176809705(-) A-I      intronic chr2:176809800(-) A-I      intronic chr2:176810150(-) A-I      intronic chr2:176845513(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LNPK	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LNPK

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.