Basic Information:

  VIRBase ID:  

VHID00513915

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7951

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PRR3:  NM_025263     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PRR3
miRBase Accession/Entrez ID	MIMAT0001581	80742
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAT56

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRR3	chr6:30524674-30524675(+) m6A 5'UTR       - chr6:30524680-30524681(+) m6A 5'UTR       - chr6:30524743-30524744(+) m6A 5'UTR       24284625//24981863//22608085 chr6:30525054-30525055(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr6:30525116-30525117(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr6:30525196-30525197(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr6:30525969-30525970(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr6:30529110-30529111(+) m6A exon//intron       24284625 chr6:30529180-30529181(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr6:30529205-30529206(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:30529240-30529241(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:30529266-30529267(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:30529282-30529283(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:30529314-30529315(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr6:30529324-30529325(+) m6A exon//intron       24284625//24981863//22608085 chr6:30529641-30529642(+) m6A CDS//exon       24284625 chr6:30529761-30529762(+) m6A CDS//exon       24284625 chr6:30529818-30529819(+) m6A CDS//exon       24284625 chr6:30529826-30529827(+) m6A CDS//exon       24284625 chr6:30530225-30530226(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr6:30530259-30530260(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr6:30530273-30530274(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:30530486-30530487(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30530499-30530500(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30530563-30530564(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:30530570-30530571(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr6:30530737-30530738(+) m6A 3'UTR//exon       24284625//27773535 chr6:30530894-30530895(+) m6A 3'UTR//exon       24284625//24209618//27773535//22608085 chr6:30531003-30531004(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:30531036-30531037(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:30531048-30531049(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:30531105-30531106(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:30531177-30531178(+) m6A 3'UTR//exon       24284625//27773535 chr6:30531257-30531258(+) m6A 3'UTR//exon       24284625//27773535 chr6:30531323-30531324(+) m6A 3'UTR//exon       27773535 chr6:30531333-30531334(+) m6A 3'UTR//exon       27773535 chr6:30531349-30531350(+) m6A 3'UTR//exon       27773535 chr6:30531414-30531415(+) m6A 3'UTR//exon       24981863 chr6:30531483-30531484(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PRR3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PRR3

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.