Detail Information

Basic Information:


  VIRBase ID:  

VHID00513884

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           WDR82:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p WDR82
miRBase
Accession/Entrez ID		 MIMAT0001581 80335
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - MST107//MSTP107//PRO2730//PRO34047//SWD2//TMEM113//WDR82A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR WDR82
chr3:52299310(-) A-I      intronic
chr3:52299188(-) A-I      intronic
chr3:52308836(-) A-I      intronic
chr3:52308976(-) A-I      intronic
chr3:52298872(-) A-I      intronic
chr3:52303007(-) A-I      intronic
chr3:52304354(-) A-I      intronic
chr3:52298840(-) A-I      intronic
chr3:52298837(-) A-I      intronic
chr3:52297062(-) A-I      intronic
chr3:52297061(-) A-I      intronic
chr3:52309075(-) A-I      intronic
chr3:52309137(-) A-I      intronic
chr3:52309174(-) A-I      intronic
chr3:52305938(-) A-I      intronic
chr3:52305988(-) A-I      intronic
chr3:52305981(-) A-I      intronic
chr3:52306558(-) A-I      intronic
chr3:52307220(-) A-I      intronic
chr3:52302991(-) A-I      intronic
chr3:52307866(-) A-I      intronic
chr3:52300649(-) A-I      intronic
chr3:52307905(-) A-I      intronic
chr3:52307823(-) A-I      intronic
chr3:52307805(-) A-I      intronic
chr3:52307713(-) A-I      intronic
chr3:52307704(-) A-I      intronic
chr3:52300657(-) A-I      intronic
chr3:52307339(-) A-I      intronic
chr3:52307243(-) A-I      intronic
chr3:52302905(-) A-I      intronic
chr3:52302939(-) A-I      intronic
chr3:52303025(-) A-I      intronic
chr3:52303058(-) A-I      intronic
chr3:52307919(-) A-I      intronic
chr3:52303081(-) A-I      intronic
chr3:52303299(-) A-I      intronic
chr3:52303311(-) A-I      intronic
chr3:52303382(-) A-I      intronic
chr3:52303616(-) A-I      intronic
chr3:52303699(-) A-I      intronic
chr3:52304273(-) A-I      intronic
chr3:52307910(-) A-I      intronic
chr3:52304300(-) A-I      intronic
chr3:52304315(-) A-I      intronic
chr3:52307911(-) A-I      intronic
chr3:52304331(-) A-I      intronic
chr3:52305888(-) A-I      intronic
chr3:52305958(-) A-I      intronic
chr3:52307352(-) A-I      intronic
chr3:52307814(-) A-I      intronic
chr3:52308411(-) A-I      intronic
chr3:52310325(-) A-I      intronic
chr3:52307815(-) A-I      intronic
chr3:52297110(-) A-I      intronic
chr3:52303732(-) A-I      intronic
chr3:52303013(-) A-I      intronic
chr3:52307338(-) A-I      intronic
chr3:52303001(-) A-I      intronic
chr3:52298841(-) A-I      intronic
chr3:52300627(-) A-I      intronic
chr3:52303024(-) A-I      intronic
chr3:52307411(-) A-I      intronic
chr3:52307702(-) A-I      intronic
chr3:52299168(-) A-I      intronic
chr3:52307722(-) A-I      intronic
chr3:52305949(-) A-I      intronic
chr3:52302946(-) A-I      intronic
chr3:52302952(-) A-I      intronic
chr3:52306023(-) A-I      intronic
chr3:52308381(-) A-I      intronic
chr3:52307734(-) A-I      intronic
chr3:52303027(-) A-I      intronic
chr3:52289065(-) A-I      3'UTR
chr3:52289055(-) A-I      3'UTR
chr3:52300743(-) A-I      intronic
chr3:52304318(-) A-I      intronic
chr3:52306006(-) A-I      intronic
chr3:52303663(-) A-I      intronic
chr3:52307802(-) A-I      intronic
chr3:52299269(-) A-I      intronic
chr3:52307733(-) A-I      intronic
chr3:52308654(-) A-I      intronic
chr3:52307856(-) A-I      intronic
chr3:52298883(-) A-I      intronic
chr3:52307811(-) A-I      intronic
chr3:52303104(-) A-I      intronic
chr3:52299865(-) A-I      intronic
chr3:52299204(-) A-I      intronic
chr3:52303588(-) A-I      intronic
chr3:52303008(-) A-I      intronic
chr3:52307762(-) A-I      intronic
chr3:52299730(-) A-I      intronic
chr3:52307347(-) A-I      intronic
chr3:52303659(-) A-I      intronic
chr3:52304423(-) A-I      intronic
chr3:52307917(-) A-I      intronic
chr3:52307855(-) A-I      intronic
chr3:52299149(-) A-I      intronic
chr3:52305966(-) A-I      intronic
chr3:52307776(-) A-I      intronic
chr3:52308835(-) A-I      intronic
chr3:52303063(-) A-I      intronic
chr3:52302889(-) A-I      intronic
chr3:52299688(-) A-I      intronic
chr3:52299864(-) A-I      intronic
chr3:52299158(-) A-I      intronic
chr3:52303004(-) A-I      intronic
chr3:52307858(-) A-I      intronic
chr3:52299075(-) A-I      intronic
chr3:52303582(-) A-I      intronic
chr3:52307786(-) A-I      intronic
chr3:52303683(-) A-I      intronic
chr3:52304329(-) A-I      intronic
chr3:52307742(-) A-I      intronic
chr3:52304409(-) A-I      intronic
chr3:52305865(-) A-I      intronic
chr3:52306529(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED WDR82
chr3:52305888(-) A-I intron -    21960545
chr3:52298841(-) A-G intron -    22484847
chr3:52299204(-) A-G intron -    22484847
chr3:52300627(-) A-G intron -    22484847
chr3:52300733(-) A-G intron -    22484847
chr3:52300743(-) A-G intron -    22484847
chr3:52302946(-) A-G intron -    22484847
chr3:52302984(-) A-G intron -    22484847
chr3:52303001(-) A-G intron -    22484847
chr3:52303013(-) A-G intron -    22484847
chr3:52303063(-) A-G intron -    22484847
chr3:52303582(-) A-G intron -    22484847
chr3:52303588(-) A-G intron -    22484847
chr3:52303634(-) A-G intron -    22484847
chr3:52303646(-) A-G intron -    22484847
chr3:52303663(-) A-G intron -    22484847
chr3:52303683(-) A-G intron -    22484847
chr3:52303694(-) A-G intron -    22484847
chr3:52303732(-) A-G intron -    22484847
chr3:52303740(-) A-G intron -    22484847
chr3:52304423(-) A-G intron -    22484847
chr3:52305949(-) A-G intron -    22484847
chr3:52306006(-) A-G intron -    22484847
chr3:52306023(-) A-G intron -    22484847
chr3:52307338(-) A-G intron -    22484847
chr3:52307347(-) A-G intron -    22484847
chr3:52307352(-) A-G intron -    22484847
chr3:52307722(-) A-G intron -    22484847
chr3:52307734(-) A-G intron -    22484847
chr3:52307762(-) A-G intron -    22484847
chr3:52307776(-) A-G intron -    22484847
chr3:52307786(-) A-G intron -    22484847
chr3:52307811(-) A-G intron -    22484847
chr3:52307813(-) A-G intron -    22484847
chr3:52307814(-) A-G intron -    22484847
chr3:52307815(-) A-G intron -    22484847
chr3:52307855(-) A-G intron -    22484847
chr3:52307856(-) A-G intron -    22484847
chr3:52307857(-) A-G intron -    22484847
chr3:52307858(-) A-G intron -    22484847
chr3:52307917(-) A-G intron -    22484847
chr3:52308835(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase WDR82
chr3:52288984-52288985(-) m6A 3'UTR//exon       24284625//24209618
chr3:52289054-52289055(-) m6A 3'UTR//exon       24209618
chr3:52289150-52289151(-) m6A 3'UTR//exon       24209618
chr3:52290832-52290833(-) m6A 3'UTR//exon       24981863//27773535
chr3:52290932-52290933(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr3:52290946-52290947(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr3:52290979-52290980(-) m6A 3'UTR//exon       24284625//24209618//27773535
chr3:52290991-52290992(-) m6A 3'UTR//exon       24284625//27773535
chr3:52291235-52291236(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291287-52291288(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291298-52291299(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291314-52291315(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291398-52291399(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291441-52291442(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291452-52291453(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52292623-52292624(-) m6A CDS//exon       24284625//24209618//22608085
chr3:52312312-52312313(-) m6A 5'UTR//CDS//intron       27371828//22575960
chr3:52312318-52312319(-) m6A 5'UTR//CDS//intron       27371828//22575960
chr3:52312527-52312528(-) m1A 5'UTR//intron       26863196//26863410
chr3:52312547-52312548(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr3:52312632-52312633(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr3:52318594-52318595(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate WDR82
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: WDR82

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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