Detail Information

Basic Information:


  VIRBase ID:  

VHID00513790

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           THOC7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p THOC7
miRBase
Accession/Entrez ID		 MIMAT0001581 80145
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - fSAP24//hTREX30//NIF3L1BP1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR THOC7
chr3:63838776(-) A-I      intronic
chr3:63847713(-) A-I      intronic
chr3:63829332(-) A-I      intronic
chr3:63836395(-) A-I      intronic
chr3:63834952(-) A-I      intronic
chr3:63836407(-) A-I      intronic
chr3:63836436(-) A-I      intronic
chr3:63836439(-) A-I      intronic
chr3:63836440(-) A-I      intronic
chr3:63824621(-) A-I      intronic
chr3:63829021(-) A-I      intronic
chr3:63828982(-) A-I      intronic
chr3:63828967(-) A-I      intronic
chr3:63828916(-) A-I      intronic
chr3:63828905(-) A-I      intronic
chr3:63828750(-) A-I      intronic
chr3:63828680(-) A-I      intronic
chr3:63828677(-) A-I      intronic
chr3:63828668(-) A-I      intronic
chr3:63828534(-) A-I      intronic
chr3:63828530(-) A-I      intronic
chr3:63828520(-) A-I      intronic
chr3:63824822(-) A-I      intronic
chr3:63836339(-) A-I      intronic
chr3:63824616(-) A-I      intronic
chr3:63836348(-) A-I      intronic
chr3:63836368(-) A-I      intronic
chr3:63836388(-) A-I      intronic
chr3:63836391(-) A-I      intronic
chr3:63836431(-) A-I      intronic
chr3:63836450(-) A-I      intronic
chr3:63836469(-) A-I      intronic
chr3:63836475(-) A-I      intronic
chr3:63836310(-) A-I      intronic
chr3:63836278(-) A-I      intronic
chr3:63835942(-) A-I      intronic
chr3:63834924(-) A-I      intronic
chr3:63834915(-) A-I      intronic
chr3:63834906(-) A-I      intronic
chr3:63834895(-) A-I      intronic
chr3:63834891(-) A-I      intronic
chr3:63834871(-) A-I      intronic
chr3:63833301(-) A-I      intronic
chr3:63833294(-) A-I      intronic
chr3:63833273(-) A-I      intronic
chr3:63838582(-) A-I      intronic
chr3:63838605(-) A-I      intronic
chr3:63833247(-) A-I      intronic
chr3:63833244(-) A-I      intronic
chr3:63833221(-) A-I      intronic
chr3:63833203(-) A-I      intronic
chr3:63833197(-) A-I      intronic
chr3:63833196(-) A-I      intronic
chr3:63832362(-) A-I      intronic
chr3:63832279(-) A-I      intronic
chr3:63832259(-) A-I      intronic
chr3:63838718(-) A-I      intronic
chr3:63838745(-) A-I      intronic
chr3:63832216(-) A-I      intronic
chr3:63832199(-) A-I      intronic
chr3:63832176(-) A-I      intronic
chr3:63832111(-) A-I      intronic
chr3:63829551(-) A-I      intronic
chr3:63829403(-) A-I      intronic
chr3:63829347(-) A-I      intronic
chr3:63836400(-) A-I      intronic
chr3:63846011(-) A-I      intronic
chr3:63838770(-) A-I      intronic
chr3:63839395(-) A-I      intronic
chr3:63826184(-) A-I      intronic
chr3:63836509(-) A-I      intronic
chr3:63834940(-) A-I      intronic
chr3:63836041(-) A-I      intronic
chr3:63828997(-) A-I      intronic
chr3:63836519(-) A-I      intronic
chr3:63838635(-) A-I      intronic
chr3:63834820(-) A-I      intronic
chr3:63838740(-) A-I      intronic
chr3:63836470(-) A-I      intronic
chr3:63833291(-) A-I      intronic
chr3:63836277(-) A-I      intronic
chr3:63828887(-) A-I      intronic
chr3:63838744(-) A-I      intronic
chr3:63834819(-) A-I      intronic
chr3:63833407(-) A-I      intronic
chr3:63833409(-) A-I      intronic
chr3:63836529(-) A-I      intronic
chr3:63835973(-) A-I      intronic
chr3:63838664(-) A-I      intronic
chr3:63838705(-) A-I      intronic
chr3:63835022(-) A-I      intronic
chr3:63834900(-) A-I      intronic
chr3:63833313(-) A-I      intronic
chr3:63838741(-) A-I      intronic
chr3:63836017(-) A-I      intronic
chr3:63828550(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED THOC7
chr3:63836017(-) A-G intron -    22484847
chr3:63836041(-) A-G intron -    22484847
chr3:63836400(-) A-G intron -    22484847
chr3:63836427(-) A-G intron -    22484847
chr3:63836433(-) A-G intron -    22484847
chr3:63836519(-) A-G intron -    22484847
chr3:63838705(-) A-G intron -    22484847
chr3:63838740(-) A-G intron -    22484847
chr3:63838741(-) A-G intron -    22484847
chr3:63838744(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase THOC7
chr3:63820881-63820882(-) m6A 3'UTR//CDS//exon       24981863
chr3:63821062-63821063(-) m6A 3'UTR//CDS//exon       24981863
chr3:63821983-63821984(-) m6A 3'UTR//CDS//exon       24981863
chr3:63821994-63821995(-) m6A 3'UTR//CDS//exon       24981863
chr3:63824113-63824114(-) m6A 3'UTR//CDS//exon       27773535
chr3:63849228-63849229(-) m6A exon//intron       -
chr3:63849358-63849359(-) m6A exon//intron       27773536
chr3:63849387-63849388(-) m6A exon//intron       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate THOC7
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: THOC7

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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