Basic Information:

  VIRBase ID:  

VHID00513782

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TRIM46:  NR_104150     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TRIM46
miRBase Accession/Entrez ID	MIMAT0001581	80128
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	GENEY//TRIFIC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM46	chr1:155155170(+) A-I      3'UTR chr1:155155168(+) A-I      3'UTR chr1:155155165(+) A-I      3'UTR chr1:155155121(+) A-I      3'UTR chr1:155155646(+) A-I      intronic chr1:155155571(+) A-I      intronic chr1:155155593(+) A-I      intronic chr1:155155552(+) A-I      intronic chr1:155155553(+) A-I      intronic chr1:155155133(+) A-I      3'UTR chr1:155155523(+) A-I      intronic chr1:155155568(+) A-I      intronic chr1:155155526(+) A-I      intronic chr1:155152741(+) A-I      intronic chr1:155155308(+) A-I      3'UTR chr1:155155172(+) A-I      3'UTR chr1:155155061(+) A-I      3'UTR chr1:155155130(+) A-I      3'UTR chr1:155155647(+) A-I      intronic chr1:155155146(+) A-I      3'UTR chr1:155155660(+) A-I      intronic chr1:155155408(+) A-I      intronic chr1:155155332(+) A-I      3'UTR chr1:155155451(+) A-I      intronic chr1:155149498(+) A-I      NonSyn:Thr->Ala chr1:155155633(+) A-I      intronic chr1:155155199(+) A-I      3'UTR chr1:155155067(+) A-I      3'UTR chr1:155155208(+) A-I      3'UTR chr1:155155303(+) A-I      3'UTR chr1:155155269(+) A-I      3'UTR chr1:155155088(+) A-I      3'UTR chr1:155155185(+) A-I      3'UTR chr1:155155062(+) A-I      3'UTR chr1:155155131(+) A-I      3'UTR chr1:155155307(+) A-I      3'UTR chr1:155155407(+) A-I      intronic chr1:155155309(+) A-I      3'UTR chr1:155155198(+) A-I      3'UTR chr1:155155092(+) A-I      3'UTR chr1:155155310(+) A-I      3'UTR chr1:155155053(+) A-I      3'UTR chr1:155155467(+) A-I      intronic chr1:155155247(+) A-I      3'UTR chr1:155155437(+) A-I      intronic chr1:155154291(+) A-I      intronic chr1:155155102(+) A-I      3'UTR chr1:155155516(+) A-I      intronic chr1:155155648(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRIM46	chr1:155149498(+) A-I exon CDS    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM46	chr1:155156472-155156473(+) m6A CDS//exon       24209618//25456834 chr1:155156541-155156542(+) m6A CDS//exon       25456834 chr1:155156661-155156662(+) m6A CDS//exon       25456834 chr1:155156688-155156689(+) m6A 3'UTR//exon       25456834 chr1:155156719-155156720(+) m6A 3'UTR//exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIM46	Exosome Blood     - Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIM46

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.