Basic Information:

  VIRBase ID:  

VHID00513757

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PANK2:  NM_001324191     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PANK2
miRBase Accession/Entrez ID	MIMAT0001581	80025
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf48//HARP//HSS//NBIA1//PKAN

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PANK2	chr20:3892448(+) A-I      intronic chr20:3901053(+) A-I      intronic chr20:3901043(+) A-I      intronic chr20:3901042(+) A-I      intronic chr20:3899846(+) A-I      intronic chr20:3899843(+) A-I      intronic chr20:3899728(+) A-I      intronic chr20:3899711(+) A-I      intronic chr20:3899695(+) A-I      intronic chr20:3900967(+) A-I      intronic chr20:3892447(+) A-I      intronic chr20:3892450(+) A-I      intronic chr20:3905998(+) A-I      3'UTR chr20:3893506(+) A-I      intronic chr20:3899779(+) A-I      intronic chr20:3893454(+) A-I      intronic chr20:3893435(+) A-I      intronic chr20:3906061(+) A-I      3'UTR chr20:3892449(+) A-I      intronic chr20:3906084(+) A-I      3'UTR chr20:3899741(+) A-I      intronic chr20:3905985(+) A-I      3'UTR chr20:3892518(+) A-I      intronic chr20:3907429(+) A-I      3'UTR chr20:3892471(+) A-I      intronic chr20:3892444(+) A-I      intronic chr20:3906022(+) A-I      3'UTR chr20:3907431(+) A-I      3'UTR chr20:3872750(+) A-I      intronic chr20:3872749(+) A-I      intronic chr20:3872728(+) A-I      intronic chr20:3878447(+) A-I      intronic chr20:3900920(+) A-I      intronic chr20:3900998(+) A-I      intronic chr20:3901003(+) A-I      intronic chr20:3901004(+) A-I      intronic chr20:3901007(+) A-I      intronic chr20:3901011(+) A-I      intronic chr20:3901012(+) A-I      intronic chr20:3901143(+) A-I      intronic chr20:3901261(+) A-I      intronic chr20:3901340(+) A-I      intronic chr20:3901394(+) A-I      intronic chr20:3902421(+) A-I      intronic chr20:3902432(+) A-I      intronic chr20:3902475(+) A-I      intronic chr20:3902484(+) A-I      intronic chr20:3902499(+) A-I      intronic chr20:3902510(+) A-I      intronic chr20:3902524(+) A-I      intronic chr20:3902586(+) A-I      intronic chr20:3902602(+) A-I      intronic chr20:3896147(+) A-I      intronic chr20:3899739(+) A-I      intronic chr20:3899653(+) A-I      intronic chr20:3896190(+) A-I      intronic chr20:3872733(+) A-I      intronic chr20:3896125(+) A-I      intronic chr20:3896110(+) A-I      intronic chr20:3896050(+) A-I      intronic chr20:3896032(+) A-I      intronic chr20:3894621(+) A-I      intronic chr20:3894618(+) A-I      intronic chr20:3894612(+) A-I      intronic chr20:3894256(+) A-I      intronic chr20:3894132(+) A-I      intronic chr20:3894120(+) A-I      intronic chr20:3894090(+) A-I      intronic chr20:3894084(+) A-I      intronic chr20:3894068(+) A-I      intronic chr20:3894034(+) A-I      intronic chr20:3893581(+) A-I      intronic chr20:3893580(+) A-I      intronic chr20:3893557(+) A-I      intronic chr20:3893439(+) A-I      intronic chr20:3893401(+) A-I      intronic chr20:3893387(+) A-I      intronic chr20:3887716(+) A-I      intronic chr20:3887704(+) A-I      intronic chr20:3887585(+) A-I      intronic chr20:3887546(+) A-I      intronic chr20:3886977(+) A-I      intronic chr20:3886940(+) A-I      intronic chr20:3886920(+) A-I      intronic chr20:3886873(+) A-I      intronic chr20:3886808(+) A-I      intronic chr20:3885044(+) A-I      intronic chr20:3879109(+) A-I      intronic chr20:3879108(+) A-I      intronic chr20:3878564(+) A-I      intronic chr20:3878521(+) A-I      intronic chr20:3878467(+) A-I      intronic chr20:3878228(+) A-I      intronic chr20:3878092(+) A-I      intronic chr20:3875830(+) A-I      intronic chr20:3875794(+) A-I      intronic chr20:3875792(+) A-I      intronic chr20:3875739(+) A-I      intronic chr20:3875326(+) A-I      intronic chr20:3875319(+) A-I      intronic chr20:3875251(+) A-I      intronic chr20:3872943(+) A-I      intronic chr20:3872942(+) A-I      intronic chr20:3872832(+) A-I      intronic chr20:3872814(+) A-I      intronic chr20:3872813(+) A-I      intronic chr20:3907451(+) A-I      3'UTR chr20:3907450(+) A-I      3'UTR chr20:3907574(+) A-I      3'UTR chr20:3907401(+) A-I      3'UTR chr20:3907367(+) A-I      3'UTR chr20:3906142(+) A-I      3'UTR chr20:3905907(+) A-I      3'UTR chr20:3906066(+) A-I      3'UTR chr20:3906055(+) A-I      3'UTR chr20:3905921(+) A-I      3'UTR chr20:3905936(+) A-I      3'UTR chr20:3907577(+) A-I      3'UTR chr20:3907533(+) A-I      3'UTR chr20:3907484(+) A-I      3'UTR chr20:3907434(+) A-I      3'UTR chr20:3872871(+) A-I      intronic chr20:3900949(+) A-I      intronic chr20:3892172(+) A-I      intronic chr20:3901121(+) A-I      intronic chr20:3899751(+) A-I      intronic chr20:3878147(+) A-I      intronic chr20:3901073(+) A-I      intronic chr20:3901144(+) A-I      intronic chr20:3896205(+) A-I      intronic chr20:3874718(+) A-I      intronic chr20:3901371(+) A-I      intronic chr20:3876058(+) A-I      intronic chr20:3885032(+) A-I      intronic chr20:3875670(+) A-I      intronic chr20:3893411(+) A-I      intronic chr20:3899683(+) A-I      intronic chr20:3885120(+) A-I      intronic chr20:3885148(+) A-I      intronic chr20:3900944(+) A-I      intronic chr20:3886817(+) A-I      intronic chr20:3878190(+) A-I      intronic chr20:3878505(+) A-I      intronic chr20:3882918(+) A-I      intronic chr20:3901402(+) A-I      intronic chr20:3886986(+) A-I      intronic chr20:3884957(+) A-I      intronic chr20:3886912(+) A-I      intronic chr20:3890152(+) A-I      intronic chr20:3899628(+) A-I      intronic chr20:3871836(+) A-I      intronic chr20:3892363(+) A-I      intronic chr20:3894191(+) A-I      intronic chr20:3894234(+) A-I      intronic chr20:3899572(+) A-I      intronic chr20:3876016(+) A-I      intronic chr20:3896204(+) A-I      intronic chr20:3893512(+) A-I      intronic chr20:3878452(+) A-I      intronic chr20:3878490(+) A-I      intronic chr20:3878558(+) A-I      intronic chr20:3893450(+) A-I      intronic chr20:3893517(+) A-I      intronic chr20:3873177(+) A-I      intronic chr20:3883845(+) A-I      intronic chr20:3876001(+) A-I      intronic chr20:3874740(+) A-I      intronic chr20:3894095(+) A-I      intronic chr20:3885153(+) A-I      intronic chr20:3901442(+) A-I      intronic chr20:3875684(+) A-I      intronic chr20:3875671(+) A-I      intronic chr20:3899737(+) A-I      intronic chr20:3896128(+) A-I      intronic chr20:3876849(+) A-I      intronic chr20:3901244(+) A-I      intronic chr20:3875991(+) A-I      intronic chr20:3887890(+) A-I      intronic chr20:3900984(+) A-I      intronic chr20:3872870(+) A-I      intronic chr20:3894565(+) A-I      intronic chr20:3899820(+) A-I      intronic chr20:3901005(+) A-I      intronic chr20:3901449(+) A-I      intronic chr20:3878491(+) A-I      intronic chr20:3886268(+) A-I      intronic chr20:3893441(+) A-I      intronic chr20:3886382(+) A-I      intronic chr20:3901372(+) A-I      intronic chr20:3906015(+) A-I      3'UTR chr20:3906053(+) A-I      3'UTR chr20:3906120(+) A-I      3'UTR chr20:3905955(+) A-I      3'UTR chr20:3906010(+) A-I      3'UTR chr20:3907479(+) A-I      3'UTR chr20:3905905(+) A-I      3'UTR chr20:3905961(+) A-I      3'UTR chr20:3907537(+) A-I      3'UTR chr20:3907331(+) A-I      3'UTR chr20:3907332(+) A-I      3'UTR chr20:3907337(+) A-I      3'UTR chr20:3907500(+) A-I      3'UTR chr20:3906155(+) A-I      3'UTR chr20:3906020(+) A-I      3'UTR chr20:3907496(+) A-I      3'UTR chr20:3907377(+) A-I      3'UTR chr20:3907348(+) A-I      3'UTR chr20:3906081(+) A-I      3'UTR chr20:3906103(+) A-I      3'UTR chr20:3907542(+) A-I      3'UTR chr20:3905984(+) A-I      3'UTR chr20:3905925(+) A-I      3'UTR chr20:3906090(+) A-I      3'UTR chr20:3907409(+) A-I      3'UTR chr20:3907385(+) A-I      3'UTR chr20:3905950(+) A-I      3'UTR chr20:3907410(+) A-I      3'UTR chr20:3907443(+) A-I      3'UTR chr20:3906064(+) A-I      3'UTR chr20:3907353(+) A-I      3'UTR chr20:3907521(+) A-I      3'UTR chr20:3907470(+) A-I      3'UTR chr20:3907411(+) A-I      3'UTR chr20:3893382(+) A-I      intronic chr20:3892143(+) A-I      intronic chr20:3878193(+) A-I      intronic chr20:3901339(+) A-I      intronic chr20:3875997(+) A-I      intronic chr20:3893432(+) A-I      intronic chr20:3900987(+) A-I      intronic chr20:3901084(+) A-I      intronic chr20:3883995(+) A-I      intronic chr20:3902523(+) A-I      intronic chr20:3899811(+) A-I      intronic chr20:3901365(+) A-I      intronic chr20:3899827(+) A-I      intronic chr20:3901381(+) A-I      intronic chr20:3886255(+) A-I      intronic chr20:3900943(+) A-I      intronic chr20:3901016(+) A-I      intronic chr20:3899793(+) A-I      intronic chr20:3892453(+) A-I      intronic chr20:3893553(+) A-I      intronic chr20:3899657(+) A-I      intronic chr20:3900985(+) A-I      intronic chr20:3900909(+) A-I      intronic chr20:3871838(+) A-I      intronic chr20:3893499(+) A-I      intronic chr20:3896111(+) A-I      intronic chr20:3893518(+) A-I      intronic chr20:3875087(+) A-I      intronic chr20:3877002(+) A-I      intronic chr20:3892158(+) A-I      intronic chr20:3894094(+) A-I      intronic chr20:3878964(+) A-I      intronic chr20:3901437(+) A-I      intronic chr20:3885093(+) A-I      intronic chr20:3872884(+) A-I      intronic chr20:3879013(+) A-I      intronic chr20:3899615(+) A-I      intronic chr20:3899654(+) A-I      intronic chr20:3894174(+) A-I      intronic chr20:3899764(+) A-I      intronic chr20:3876789(+) A-I      intronic chr20:3899833(+) A-I      intronic chr20:3902594(+) A-I      intronic chr20:3894091(+) A-I      intronic chr20:3901302(+) A-I      intronic chr20:3893509(+) A-I      intronic chr20:3899592(+) A-I      intronic chr20:3901327(+) A-I      intronic chr20:3901002(+) A-I      intronic chr20:3899666(+) A-I      intronic chr20:3886810(+) A-I      intronic chr20:3875744(+) A-I      intronic chr20:3899633(+) A-I      intronic chr20:3884016(+) A-I      intronic chr20:3878951(+) A-I      intronic chr20:3895391(+) A-I      intronic chr20:3899720(+) A-I      intronic chr20:3893360(+) A-I      intronic chr20:3893503(+) A-I      intronic chr20:3893344(+) A-I      intronic chr20:3893447(+) A-I      intronic chr20:3893415(+) A-I      intronic chr20:3899835(+) A-I      intronic chr20:3886466(+) A-I      intronic chr20:3901239(+) A-I      intronic chr20:3878259(+) A-I      intronic chr20:3902497(+) A-I      intronic chr20:3900904(+) A-I      intronic chr20:3879663(+) A-I      intronic chr20:3901085(+) A-I      intronic chr20:3879056(+) A-I      intronic chr20:3878947(+) A-I      intronic chr20:3899696(+) A-I      intronic chr20:3878399(+) A-I      intronic chr20:3886885(+) A-I      intronic chr20:3896217(+) A-I      intronic chr20:3899680(+) A-I      intronic chr20:3899719(+) A-I      intronic chr20:3886924(+) A-I      intronic chr20:3872911(+) A-I      intronic chr20:3878599(+) A-I      intronic chr20:3873203(+) A-I      intronic chr20:3899613(+) A-I      intronic chr20:3899734(+) A-I      intronic chr20:3893358(+) A-I      intronic chr20:3878986(+) A-I      intronic chr20:3901092(+) A-I      intronic chr20:3901483(+) A-I      intronic chr20:3882891(+) A-I      intronic chr20:3875800(+) A-I      intronic chr20:3886098(+) A-I      intronic chr20:3901330(+) A-I      intronic chr20:3896174(+) A-I      intronic chr20:3901482(+) A-I      intronic chr20:3894979(+) A-I      intronic chr20:3878093(+) A-I      intronic chr20:3901247(+) A-I      intronic chr20:3886111(+) A-I      intronic chr20:3886967(+) A-I      intronic chr20:3901336(+) A-I      intronic chr20:3901277(+) A-I      intronic chr20:3902458(+) A-I      intronic chr20:3901040(+) A-I      intronic chr20:3878950(+) A-I      intronic chr20:3899821(+) A-I      intronic chr20:3876082(+) A-I      intronic chr20:3882835(+) A-I      intronic chr20:3878396(+) A-I      intronic chr20:3886906(+) A-I      intronic chr20:3871815(+) A-I      intronic chr20:3887888(+) A-I      intronic chr20:3875801(+) A-I      intronic chr20:3886973(+) A-I      intronic chr20:3893445(+) A-I      intronic chr20:3884995(+) A-I      intronic chr20:3894009(+) A-I      intronic chr20:3887626(+) A-I      intronic chr20:3884972(+) A-I      intronic chr20:3885046(+) A-I      intronic chr20:3895431(+) A-I      intronic chr20:3899794(+) A-I      intronic chr20:3874708(+) A-I      intronic chr20:3896045(+) A-I      intronic chr20:3901341(+) A-I      intronic chr20:3871889(+) A-I      intronic chr20:3893436(+) A-I      intronic chr20:3886996(+) A-I      intronic chr20:3894130(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PANK2	chr20:3899737(+) A-I intron -    22327324 chr20:3899793(+) A-I intron -    22327324 chr20:3899794(+) A-I intron -    22327324 chr20:3901149(+) A-I intron -    22327324 chr20:3901361(+) A-I intron -    22327324 chr20:3879013(+) A-G intron -    22484847 chr20:3885139(+) A-G intron -    22484847 chr20:3885153(+) A-G intron -    22484847 chr20:3893349(+) A-G intron -    22484847 chr20:3893374(+) A-G intron -    22484847 chr20:3893444(+) A-G intron -    22484847 chr20:3893512(+) A-G intron -    22484847 chr20:3896205(+) A-G intron -    22484847 chr20:3896217(+) A-G intron -    22484847 chr20:3899613(+) A-G intron -    22484847 chr20:3899654(+) A-G intron -    22484847 chr20:3899719(+) A-G intron -    22484847 chr20:3899737(+) A-G intron -    22484847 chr20:3899740(+) A-G intron -    22484847 chr20:3899764(+) A-G intron -    22484847 chr20:3899793(+) A-G intron -    22484847 chr20:3899794(+) A-G intron -    22484847 chr20:3900895(+) A-G intron -    22484847 chr20:3900939(+) A-G intron -    22484847 chr20:3901001(+) A-G intron -    22484847 chr20:3901005(+) A-G intron -    22484847 chr20:3901016(+) A-G intron -    22484847 chr20:3901070(+) A-G intron -    22484847 chr20:3901084(+) A-G intron -    22484847 chr20:3901149(+) A-G intron -    22484847 chr20:3901239(+) A-G intron -    22484847 chr20:3901327(+) A-G intron -    22484847 chr20:3901336(+) A-G intron -    22484847 chr20:3901339(+) A-G intron -    22484847 chr20:3901341(+) A-G intron -    22484847 chr20:3901361(+) A-G intron -    22484847 chr20:3901371(+) A-G intron -    22484847 chr20:3901413(+) A-G intron -    22484847 chr20:3901482(+) A-G intron -    22484847 chr20:3901483(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PANK2	chr20:3869526-3869527(+) m6A 5'UTR       22608085 chr20:3869539-3869540(+) m6A 5'UTR       22608085 chr20:3869840-3869841(+) m6A CDS//intron       25456834 chr20:3870044-3870045(+) m6A 5'UTR//CDS//intron       24209618//25456834 chr20:3870207-3870208(+) m6A CDS//intron       24209618 chr20:3888588-3888589(+) m6A 5'UTR//CDS//exon       - chr20:3888604-3888605(+) m6A 5'UTR//CDS//exon       - chr20:3888630-3888631(+) m6A 5'UTR//CDS//exon       22608085 chr20:3888638-3888639(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr20:3888758-3888759(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:3888851-3888852(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22608085 chr20:3889357-3889358(+) m6A exon//intron       24981863//22608085 chr20:3889537-3889538(+) m6A exon//intron       24981863//22608085 chr20:3889547-3889548(+) m6A exon//intron       24981863//22608085 chr20:3891246-3891247(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//22608085 chr20:3891255-3891256(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//22608085 chr20:3891335-3891336(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//22608085 chr20:3891407-3891408(+) m6A 3'UTR//5'UTR//CDS//exon       27773535//22608085 chr20:3893117-3893118(+) m6A 3'UTR//5'UTR//CDS//exon       27773535 chr20:3899436-3899437(+) m6A 3'UTR//CDS       24981863//22608085 chr20:3903967-3903968(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr20:3903990-3903991(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr20:3904009-3904010(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr20:3904041-3904042(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:3904056-3904057(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:3904140-3904141(+) m6A 3'UTR       27773535//22608085 chr20:3904549-3904550(+) m6A 3'UTR       - chr20:3904593-3904594(+) m6A 3'UTR       - chr20:3904643-3904644(+) m6A 3'UTR       - chr20:3905663-3905664(+) m6A 3'UTR//intron       25456834 chr20:3905720-3905721(+) m6A 3'UTR//intron       25456834 chr20:3905726-3905727(+) m6A 3'UTR//intron       25456834 chr20:3905733-3905734(+) m6A 3'UTR//intron       25456834 chr20:3905835-3905836(+) m6A 3'UTR//intron       25456834 chr20:3906671-3906672(+) m6A 3'UTR//intron       24981863 chr20:3906818-3906819(+) m6A 3'UTR//intron       24981863 chr20:3906834-3906835(+) m6A 3'UTR//intron       24284625//24981863 chr20:3909943-3909944(+) m6A exon//intron       - chr20:3910030-3910031(+) m6A exon//intron       - chr20:3910083-3910084(+) m6A exon//intron       - chr20:3910094-3910095(+) m6A exon//intron       - chr20:3910117-3910118(+) m6A exon//intron       - chr20:3910190-3910191(+) m6A exon//intron       - chr20:3910205-3910206(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PANK2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PANK2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.