Basic Information:

  VIRBase ID:  

VHID00513749

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          WWC2:  NM_024949     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	WWC2
miRBase Accession/Entrez ID	MIMAT0001581	80014
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	BOMB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWC2	chr4:184195856(+) A-I      intronic chr4:184218028(+) A-I      intronic chr4:184151646(+) A-I      intronic chr4:184151736(+) A-I      intronic chr4:184027337(+) A-I      intronic chr4:184027266(+) A-I      intronic chr4:184213480(+) A-I      intronic chr4:184213479(+) A-I      intronic chr4:184213274(+) A-I      intronic chr4:184027212(+) A-I      intronic chr4:184026262(+) A-I      intronic chr4:184026189(+) A-I      intronic chr4:184026256(+) A-I      intronic chr4:184032220(+) A-I      intronic chr4:184034235(+) A-I      intronic chr4:184034247(+) A-I      intronic chr4:184034305(+) A-I      intronic chr4:184195829(+) A-I      intronic chr4:184195832(+) A-I      intronic chr4:184034314(+) A-I      intronic chr4:184108976(+) A-I      intronic chr4:184231811(+) A-I      intronic chr4:184218202(+) A-I      intronic chr4:184034331(+) A-I      intronic chr4:184034346(+) A-I      intronic chr4:184048110(+) A-I      intronic chr4:184049159(+) A-I      intronic chr4:184218837(+) A-I      intronic chr4:184049401(+) A-I      intronic chr4:184049593(+) A-I      intronic chr4:184073420(+) A-I      intronic chr4:184074268(+) A-I      intronic chr4:184074916(+) A-I      intronic chr4:184099430(+) A-I      intronic chr4:184107213(+) A-I      intronic chr4:184032965(+) A-I      intronic chr4:184032960(+) A-I      intronic chr4:184028427(+) A-I      intronic chr4:184152911(+) A-I      intronic chr4:184211524(+) A-I      intronic chr4:184218593(+) A-I      intronic chr4:184218197(+) A-I      intronic chr4:184218037(+) A-I      intronic chr4:184218032(+) A-I      intronic chr4:184217993(+) A-I      intronic chr4:184108958(+) A-I      intronic chr4:184108967(+) A-I      intronic chr4:184214249(+) A-I      intronic chr4:184214170(+) A-I      intronic chr4:184213483(+) A-I      intronic chr4:184213157(+) A-I      intronic chr4:184195850(+) A-I      intronic chr4:184195839(+) A-I      intronic chr4:184195838(+) A-I      intronic chr4:184109469(+) A-I      intronic chr4:184109548(+) A-I      intronic chr4:184130564(+) A-I      intronic chr4:184151081(+) A-I      intronic chr4:184195857(+) A-I      intronic chr4:184073470(+) A-I      intronic chr4:184049424(+) A-I      intronic chr4:184049420(+) A-I      intronic chr4:184049381(+) A-I      intronic chr4:184033060(+) A-I      intronic chr4:184033005(+) A-I      intronic chr4:184151568(+) A-I      intronic chr4:184151212(+) A-I      intronic chr4:184141787(+) A-I      intronic chr4:184141771(+) A-I      intronic chr4:184132390(+) A-I      intronic chr4:184195867(+) A-I      intronic chr4:184109565(+) A-I      intronic chr4:184195881(+) A-I      intronic chr4:184151687(+) A-I      intronic chr4:184151693(+) A-I      intronic chr4:184151709(+) A-I      intronic chr4:184151710(+) A-I      intronic chr4:184218207(+) A-I      intronic chr4:184218240(+) A-I      intronic chr4:184193038(+) A-I      intronic chr4:184039136(+) A-I      intronic chr4:184218227(+) A-I      intronic chr4:184074204(+) A-I      intronic chr4:184217854(+) A-I      intronic chr4:184032318(+) A-I      intronic chr4:184032314(+) A-I      intronic chr4:184194657(+) A-I      intronic chr4:184027210(+) A-I      intronic chr4:184109556(+) A-I      intronic chr4:184218624(+) A-I      intronic chr4:184227860(+) A-I      intronic chr4:184049607(+) A-I      intronic chr4:184213554(+) A-I      intronic chr4:184073513(+) A-I      intronic chr4:184218167(+) A-I      intronic chr4:184218155(+) A-I      intronic chr4:184217832(+) A-I      intronic chr4:184075058(+) A-I      intronic chr4:184049160(+) A-I      intronic chr4:184213572(+) A-I      intronic chr4:184132450(+) A-I      intronic chr4:184049413(+) A-I      intronic chr4:184193100(+) A-I      intronic chr4:184217940(+) A-I      intronic chr4:184214247(+) A-I      intronic chr4:184211589(+) A-I      intronic chr4:184049412(+) A-I      intronic chr4:184152562(+) A-I      intronic chr4:184218205(+) A-I      intronic chr4:184027207(+) A-I      intronic chr4:184151598(+) A-I      intronic chr4:184109530(+) A-I      intronic chr4:184049371(+) A-I      intronic chr4:184152685(+) A-I      intronic chr4:184045882(+) A-I      intronic chr4:184109571(+) A-I      intronic chr4:184074979(+) A-I      intronic chr4:184147389(+) A-I      intronic chr4:184217885(+) A-I      intronic chr4:184034785(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWC2	chr4:184020467-184020468(+) m6A 5'UTR       24209618//25456834 chr4:184020705-184020706(+) m6A CDS       24284625 chr4:184124726-184124727(+) m6A 5'UTR//intron       24981863 chr4:184129107-184129108(+) m6A 5'UTR//CDS//intron       24981863 chr4:184129133-184129134(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863 chr4:184129148-184129149(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863 chr4:184129168-184129169(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184129200-184129201(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184129211-184129212(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184161376-184161377(+) m6A 3'UTR//CDS//intron       24981863 chr4:184161391-184161392(+) m6A 3'UTR//CDS//intron       24981863 chr4:184161404-184161405(+) m6A 3'UTR//CDS//intron       24981863 chr4:184174930-184174931(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184174944-184174945(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184174987-184174988(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184175014-184175015(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184175126-184175127(+) m6A 3'UTR//CDS       24981863 chr4:184175155-184175156(+) Tm intron       - chr4:184180830-184180831(+) m6A 3'UTR//CDS       24209618//24981863 chr4:184180840-184180841(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr4:184182136-184182137(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:184182179-184182180(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:184182230-184182231(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182235-184182236(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182275-184182276(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182338-184182339(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182535-184182536(+) m6A 3'UTR//CDS       24284625//24981863 chr4:184182640-184182641(+) m6A 3'UTR//CDS//intron       24284625//24981863 chr4:184201981-184201982(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202017-184202018(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202046-184202047(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202055-184202056(+) m6A CDS//exon//intron       24981863 chr4:184202116-184202117(+) m6A CDS//exon//intron       24981863 chr4:184203931-184203932(+) m6A 3'UTR//CDS       24981863 chr4:184203994-184203995(+) m6A 3'UTR//CDS       24981863 chr4:184204021-184204022(+) m6A 3'UTR//CDS       24981863 chr4:184205390-184205391(+) m6A 3'UTR//CDS       24981863 chr4:184205544-184205545(+) Tm intron       - chr4:184210596-184210597(+) m6A 3'UTR//CDS       25456834 chr4:184210606-184210607(+) m6A 3'UTR//CDS       25456834 chr4:184210613-184210614(+) m6A 3'UTR//CDS       25456834 chr4:184210618-184210619(+) m6A 3'UTR//CDS       25456834 chr4:184210678-184210679(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184210700-184210701(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184210719-184210720(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184233498-184233499(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr4:184236939-184236940(+) m6A 3'UTR       24981863//22608085 chr4:184237007-184237008(+) m6A 3'UTR       24981863 chr4:184237155-184237156(+) m6A 3'UTR       24981863 chr4:184237232-184237233(+) Y 3'UTR       26075521 chr4:184237486-184237487(+) m6A 3'UTR       24981863 chr4:184237498-184237499(+) m6A 3'UTR       24981863 chr4:184237610-184237611(+) m6A 3'UTR       24209618//24981863 chr4:184240887-184240888(+) m6A 3'UTR       25456834 chr4:184240901-184240902(+) m6A 3'UTR       25456834 chr4:184240929-184240930(+) m6A 3'UTR       25456834 chr4:184240937-184240938(+) m6A 3'UTR       25456834 chr4:184240967-184240968(+) m6A 3'UTR       25456834 chr4:184240995-184240996(+) m6A 3'UTR       25456834 chr4:184241059-184241060(+) m6A 3'UTR       25456834 chr4:184241296-184241297(+) m6A 3'UTR       24981863 chr4:184241306-184241307(+) m6A 3'UTR       24981863 chr4:184241330-184241331(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WWC2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: WWC2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.