Basic Information:

  VIRBase ID:  

VHID00513629

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PIP4K2C:  NM_024779     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PIP4K2C
miRBase Accession/Entrez ID	MIMAT0001581	79837
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PIP5K2C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIP4K2C	chr12:57992210(+) A-I      intronic chr12:57989497(+) A-I      intronic chr12:57991891(+) A-I      intronic chr12:57992108(+) A-I      intronic chr12:57991929(+) A-I      intronic chr12:57991946(+) A-I      intronic chr12:57992048(+) A-I      intronic chr12:57993846(+) A-I      intronic chr12:57991947(+) A-I      intronic chr12:57991914(+) A-I      intronic chr12:57988530(+) A-I      intronic chr12:57991883(+) A-I      intronic chr12:57990276(+) A-I      intronic chr12:57991877(+) A-I      intronic chr12:57992206(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIP4K2C	chr12:57991883(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIP4K2C	chr12:57985069-57985070(+) m6A 5'UTR       24981863 chr12:57985153-57985154(+) m6A CDS       24284625 chr12:57985162-57985163(+) m1A CDS       26863196//26863410 chr12:57988964-57988965(+) m6A 3'UTR//CDS       - chr12:57989686-57989687(+) m6A 3'UTR//CDS//intron       - chr12:57995392-57995393(+) m6A 3'UTR       24284625//24981863 chr12:57995435-57995436(+) m6A 3'UTR//intron       24284625//24981863 chr12:57995743-57995744(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr12:57995753-57995754(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr12:57995761-57995762(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:57995808-57995809(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:57995845-57995846(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:57996006-57996007(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr12:57996016-57996017(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr12:57996188-57996189(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996207-57996208(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996213-57996214(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:57996641-57996642(+) m6A 3'UTR       24209618 chr12:57996820-57996821(+) m6A 3'UTR       24284625//24981863//26404942 chr12:57996957-57996958(+) m6A 3'UTR       24981863//27773535//22608085 chr12:57997013-57997014(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PIP4K2C	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PIP4K2C

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.