Basic Information:

  VIRBase ID:  

VHID00513587

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LRRC31:  NM_001277127     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LRRC31
miRBase Accession/Entrez ID	MIMAT0001581	79782
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-293

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LRRC31	chr3:169560241(-) A-I      intronic chr3:169565200(-) A-I      intronic chr3:169560250(-) A-I      intronic chr3:169580767(-) A-I      intronic chr3:169564272(-) A-I      intronic chr3:169566342(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LRRC31	chr3:169557660-169557661(-) m6A 3'UTR       27773535 chr3:169557692-169557693(-) m6A 3'UTR       27773535 chr3:169557717-169557718(-) m6A 3'UTR       27773535 chr3:169557738-169557739(-) m6A 3'UTR       27773535 chr3:169557768-169557769(-) m6A 3'UTR       27773535 chr3:169557832-169557833(-) m6A 3'UTR//CDS       27773535 chr3:169557919-169557920(-) m6A 3'UTR//CDS       27773535 chr3:169557931-169557932(-) m6A 3'UTR//CDS       27773535 chr3:169571188-169571189(-) m6A exon//intron       27773535 chr3:169571245-169571246(-) m6A exon//intron       27773535 chr3:169571276-169571277(-) m6A exon//intron       27773535 chr3:169571364-169571365(-) m6A exon//intron       27773535 chr3:169587543-169587544(-) m6A CDS//exon       27773535 chr3:169587555-169587556(-) m6A CDS//exon       27773535 chr3:169587573-169587574(-) m6A CDS//exon       27773535 chr3:169587585-169587586(-) m6A CDS//exon       27773535 chr3:169587615-169587616(-) m6A 5'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LRRC31	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LRRC31

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.