Detail Information

Basic Information:


  VIRBase ID:  

VHID00513361

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           DERL1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p DERL1
miRBase
Accession/Entrez ID		 MIMAT0001581 79139
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DER-1//DER1//derlin-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DERL1
chr8:124045920(-) A-I      intronic
chr8:124045821(-) A-I      intronic
chr8:124045754(-) A-I      intronic
chr8:124045161(-) A-I      intronic
chr8:124045835(-) A-I      intronic
chr8:124045900(-) A-I      intronic
chr8:124045376(-) A-I      intronic
chr8:124045265(-) A-I      intronic
chr8:124045240(-) A-I      intronic
chr8:124045209(-) A-I      intronic
chr8:124045767(-) A-I      intronic
chr8:124045378(-) A-I      intronic
chr8:124044467(-) A-I      intronic
chr8:124044472(-) A-I      intronic
chr8:124045871(-) A-I      intronic
chr8:124045976(-) A-I      intronic
chr8:124045164(-) A-I      intronic
chr8:124043702(-) A-I      intronic
chr8:124045223(-) A-I      intronic
chr8:124045182(-) A-I      intronic
chr8:124044542(-) A-I      intronic
chr8:124042217(-) A-I      intronic
chr8:124044477(-) A-I      intronic
chr8:124045983(-) A-I      intronic
chr8:124044554(-) A-I      intronic
chr8:124044550(-) A-I      intronic
chr8:124044607(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DERL1
chr8:124043702(-) A-G intron -    22484847
chr8:124044550(-) A-G intron -    22484847
chr8:124045164(-) A-G intron -    22484847
chr8:124045240(-) A-G intron -    22484847
chr8:124045265(-) A-G intron -    22484847
chr8:124045378(-) A-G intron -    22484847
chr8:124045739(-) A-G intron -    22484847
chr8:124045767(-) A-G intron -    22484847
chr8:124045861(-) A-G intron -    22484847
chr8:124045871(-) A-G intron -    22484847
chr8:124045921(-) A-G intron -    22484847
chr8:124045976(-) A-G intron -    22484847
chr8:124045983(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DERL1
chr8:124027128-124027129(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr8:124027150-124027151(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr8:124027330-124027331(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr8:124027345-124027346(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr8:124027448-124027449(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr8:124027475-124027476(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr8:124027558-124027559(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr8:124027594-124027595(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr8:124027693-124027694(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr8:124027725-124027726(-) m6A CDS//exon       24284625//24209618//27773535//27371828//22608085
chr8:124054345-124054346(-) m6A CDS       27773536
chr8:124054354-124054355(-) m6A CDS       27773536
chr8:124054453-124054454(-) m6A 5'UTR       24981863//27371828//27773536
chr8:124054589-124054590(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DERL1
Chromatin HeLa-S3 cells|K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: DERL1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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