Basic Information:

  VIRBase ID:  

VHID00513352

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          C1orf116:  NM_001083924     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	C1orf116
miRBase Accession/Entrez ID	MIMAT0001581	79098
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SARG

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C1orf116	chr1:207194769-207194770(-) m6A 3'UTR       25456834//24981863 chr1:207194816-207194817(-) m6A 3'UTR       25456834//24981863 chr1:207194912-207194913(-) m6A 3'UTR       25456834//24981863 chr1:207194929-207194930(-) m6A 3'UTR       25456834//24981863 chr1:207195257-207195258(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr1:207195267-207195268(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr1:207195283-207195284(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr1:207195301-207195302(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr1:207195317-207195318(-) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr1:207195347-207195348(-) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr1:207195419-207195420(-) m6A CDS       25456834//24981863//22575960 chr1:207195561-207195562(-) m6A CDS       24209618//25456834//24981863 chr1:207195595-207195596(-) m6A CDS       25456834//24981863 chr1:207195638-207195639(-) m6A CDS       24209618//25456834//24981863 chr1:207195675-207195676(-) m6A CDS       24209618//25456834//24981863 chr1:207195683-207195684(-) m6A CDS       24209618//25456834//24981863 chr1:207195753-207195754(-) m6A CDS       25456834//24981863 chr1:207195973-207195974(-) m6A CDS       24981863 chr1:207195983-207195984(-) m6A CDS       24981863 chr1:207196016-207196017(-) m6A CDS       24981863 chr1:207196248-207196249(-) m6A CDS       24981863//27773535 chr1:207196254-207196255(-) m6A CDS       24981863//27773535 chr1:207196348-207196349(-) m6A CDS       24209618//25456834//24981863//27773535 chr1:207196384-207196385(-) m6A 5'UTR//CDS       24209618//25456834//24981863 chr1:207196442-207196443(-) m6A 5'UTR//CDS       24209618//25456834//24981863 chr1:207196491-207196492(-) m6A 5'UTR//CDS       24209618//25456834//24981863 chr1:207196595-207196596(-) m6A 5'UTR//CDS       24209618//25456834//24981863 chr1:207196628-207196629(-) m6A 5'UTR//CDS       24209618//25456834//24981863//27773535 chr1:207196674-207196675(-) m6A 5'UTR//CDS       24209618//25456834//24981863//27773535 chr1:207196780-207196781(-) m6A 5'UTR//CDS       25456834//24981863//27773535 chr1:207196810-207196811(-) m6A 5'UTR//CDS       24981863 chr1:207201011-207201012(-) m6A 5'UTR//intron       24981863 chr1:207205968-207205969(-) m6A 5'UTR       24981863 chr1:207206018-207206019(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	C1orf116	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: C1orf116

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.