Basic Information:
VIRBase ID: VHID00513339
Virus: Human herpesvirus 5 strain AD169
Host: Homo sapiens
Confidence Score: 0.7311
Interaction Type: Virus-Host interaction
Predicted Binding:
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Interactor Information:
Interactor1
Interactor2
Symbol
hcmv-miR-US25-1-5p
WDR77
miRBase Accession/Entrez ID
MIMAT0001581
79084
Organism
Human herpesvirus 5 strain AD169
Homo sapiens
Category
miRNA
mRNA
Alias
-
HKMT1069//MEP-50//MEP50//Nbla10071//p44//p44/Mep50
RNA Editing:
Resource
Symbol
Editing Position
Change
Genetic Region
RADAR
WDR77
RNA Modification:
Resource
Symbol
ModificationPosition
Type
Genomic Context
PMID
RMBase
WDR77
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
WDR77
Interaction Network (The top 100 interactions) :
Interactor1: hcmv-miR-US25-1-5p
Interactor2: WDR77
Evidence Support:
Strong-Evidence
RISC-IP
Support Database
ViRBase
References:
PMID
20585629
Target region
5'UTR
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
HEK293 cells
Interactor2 expression
None
Description
Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.