Basic Information:

  VIRBase ID:  

VHID00513313

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZFYVE21:  NM_001198953     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZFYVE21
miRBase Accession/Entrez ID	MIMAT0001581	79038
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCVP7TP1//ZF21

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE21	chr14:104185726(+) A-I      intronic chr14:104189052(+) A-I      intronic chr14:104188778(+) A-I      intronic chr14:104188792(+) A-I      intronic chr14:104188893(+) A-I      intronic chr14:104188973(+) A-I      intronic chr14:104185721(+) A-I      intronic chr14:104193483(+) A-I      intronic chr14:104185650(+) A-I      intronic chr14:104185713(+) A-I      intronic chr14:104193492(+) A-I      intronic chr14:104185741(+) A-I      intronic chr14:104193480(+) A-I      intronic chr14:104189097(+) A-I      intronic chr14:104197432(+) A-I      intronic chr14:104188901(+) A-I      intronic chr14:104189035(+) A-I      intronic chr14:104189176(+) A-I      intronic chr14:104189261(+) A-I      intronic chr14:104188818(+) A-I      intronic chr14:104187260(+) A-I      intronic chr14:104188759(+) A-I      intronic chr14:104187183(+) A-I      intronic chr14:104187259(+) A-I      intronic chr14:104188831(+) A-I      intronic chr14:104185780(+) A-I      intronic chr14:104187277(+) A-I      intronic chr14:104188748(+) A-I      intronic chr14:104189101(+) A-I      intronic chr14:104197437(+) A-I      intronic chr14:104188902(+) A-I      intronic chr14:104188821(+) A-I      intronic chr14:104185686(+) A-I      intronic chr14:104188715(+) A-I      intronic chr14:104185494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE21	chr14:104197572(+) A-I intron -    21960545 chr14:104197527(+) G-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE21	chr14:104191030-104191031(+) m6A exon//intron       - chr14:104199347-104199348(+) m6A CDS//exon       24981863 chr14:104199396-104199397(+) m6A 3'UTR//exon       24981863 chr14:104199411-104199412(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZFYVE21	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZFYVE21

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.