Basic Information:

  VIRBase ID:  

VHID00513163

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          YTHDC2:  NM_022828     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	YTHDC2
miRBase Accession/Entrez ID	MIMAT0001581	64848
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAHL//hYTHDC2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YTHDC2	chr5:112853806(+) A-I      intronic chr5:112853719(+) A-I      intronic chr5:112853715(+) A-I      intronic chr5:112857241(+) A-I      intronic chr5:112857285(+) A-I      intronic chr5:112857353(+) A-I      intronic chr5:112925335(+) A-I      intronic chr5:112925399(+) A-I      intronic chr5:112925374(+) A-I      intronic chr5:112925370(+) A-I      intronic chr5:112925203(+) A-I      intronic chr5:112894540(+) A-I      intronic chr5:112864489(+) A-I      intronic chr5:112854002(+) A-I      intronic chr5:112857317(+) A-I      intronic chr5:112924459(+) A-I      intronic chr5:112854137(+) A-I      intronic chr5:112925381(+) A-I      intronic chr5:112894539(+) A-I      intronic chr5:112857266(+) A-I      intronic chr5:112854164(+) A-I      intronic chr5:112854138(+) A-I      intronic chr5:112854133(+) A-I      intronic chr5:112925262(+) A-I      intronic chr5:112925368(+) A-I      intronic chr5:112925267(+) A-I      intronic chr5:112857173(+) A-I      intronic chr5:112893282(+) A-I      intronic chr5:112924561(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YTHDC2	chr5:112853991(+) A-G intron -    22484847 chr5:112854133(+) A-G intron -    22484847 chr5:112854134(+) A-G intron -    22484847 chr5:112854137(+) A-G intron -    22484847 chr5:112854138(+) A-G intron -    22484847 chr5:112857251(+) A-G intron -    22484847 chr5:112906050(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YTHDC2	chr5:112860827-112860828(+) m6A CDS//intron       24981863 chr5:112927754-112927755(+) m6A CDS//exon       24981863 chr5:112929007-112929008(+) m6A CDS//exon       22608085 chr5:112929022-112929023(+) m6A CDS//exon       22608085 chr5:112929066-112929067(+) m6A CDS//exon       24284625//24981863//22608085 chr5:112929136-112929137(+) m6A exon//intron       24284625//24981863//22608085 chr5:112929179-112929180(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929197-112929198(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929241-112929242(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929301-112929302(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929542-112929543(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929593-112929594(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929630-112929631(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929642-112929643(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929655-112929656(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929737-112929738(+) m6A 3'UTR//exon       27773535 chr5:112930025-112930026(+) m6A 3'UTR//exon       24981863 chr5:112930042-112930043(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	YTHDC2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: YTHDC2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.