Detail Information

Basic Information:


  VIRBase ID:  

VHID00513145

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           DDX31:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p DDX31
miRBase
Accession/Entrez ID		 MIMAT0001581 64794
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - PPP1R25

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DDX31
chr9:135542866(-) A-I      intronic
chr9:135488549(-) A-I      intronic
chr9:135488487(-) A-I      intronic
chr9:135539861(-) A-I      intronic
chr9:135489074(-) A-I      intronic
chr9:135489005(-) A-I      intronic
chr9:135542868(-) A-I      intronic
chr9:135544093(-) A-I      intronic
chr9:135542933(-) A-I      intronic
chr9:135542878(-) A-I      intronic
chr9:135542890(-) A-I      intronic
chr9:135488878(-) A-I      intronic
chr9:135544119(-) A-I      intronic
chr9:135488468(-) A-I      intronic
chr9:135511245(-) A-I      intronic
chr9:135529763(-) A-I      intronic
chr9:135488392(-) A-I      intronic
chr9:135488432(-) A-I      intronic
chr9:135542988(-) A-I      intronic
chr9:135542798(-) A-I      intronic
chr9:135529753(-) A-I      intronic
chr9:135510962(-) A-I      intronic
chr9:135542908(-) A-I      intronic
chr9:135542275(-) A-I      intronic
chr9:135510910(-) A-I      intronic
chr9:135542515(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DDX31
chr9:135498478(-) C-T intron -    22484847
chr9:135542275(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DDX31
chr9:135469720-135469721(-) m6A 3'UTR//exon       27773535
chr9:135469800-135469801(-) m6A 3'UTR//exon       27773535//22608085
chr9:135470048-135470049(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr9:135470227-135470228(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:135470269-135470270(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr9:135470277-135470278(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr9:135470299-135470300(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr9:135470317-135470318(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr9:135470468-135470469(-) m6A CDS//exon       24284625//27773535
chr9:135470479-135470480(-) m6A CDS//exon       24284625//27773535
chr9:135487498-135487499(-) Am CDS//exon       -
chr9:135487538-135487539(-) m6A CDS//exon       24284625//27773535
chr9:135487685-135487686(-) m6A exon//intron       27773535
chr9:135537833-135537834(-) m6A CDS//exon       24284625//27773535//22608085
chr9:135537852-135537853(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr9:135537871-135537872(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr9:135537884-135537885(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr9:135537897-135537898(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr9:135537964-135537965(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr9:135537973-135537974(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr9:135537988-135537989(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr9:135538012-135538013(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr9:135538699-135538700(-) m6A intron       27773535//27371828
chr9:135545323-135545324(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828//27773536//22575960
chr9:135545429-135545430(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22575960//22608085
chr9:135545583-135545584(-) m6A CDS//exon       24284625//25456834//24981863//22575960
chr9:135545701-135545702(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DDX31
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: DDX31

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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