Basic Information:

  VIRBase ID:  

VHID00513115

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RUSF1:  NM_022744     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RUSF1
miRBase Accession/Entrez ID	MIMAT0001581	64755
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C16orf58//RUS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUSF1	chr16:31512834(-) A-I      intronic chr16:31505503(-) A-I      intronic chr16:31512670(-) A-I      intronic chr16:31512817(-) A-I      intronic chr16:31505534(-) A-I      intronic chr16:31505513(-) A-I      intronic chr16:31505502(-) A-I      intronic chr16:31515817(-) A-I      intronic chr16:31518183(-) A-I      intronic chr16:31505540(-) A-I      intronic chr16:31506101(-) A-I      intronic chr16:31506125(-) A-I      intronic chr16:31506250(-) A-I      intronic chr16:31505920(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RUSF1	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RUSF1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.