Basic Information:

  VIRBase ID:  

VHID00512987

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TINAGL1:  NM_022164     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TINAGL1
miRBase Accession/Entrez ID	MIMAT0001581	64129
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARG1//LCN7//LIECG3//TINAGRP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TINAGL1	chr1:32047721(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TINAGL1	chr1:32051454-32051455(+) m6A CDS//exon       24284625 chr1:32052273-32052274(+) m6A exon//intron       24209618 chr1:32052563-32052564(+) m6A CDS//exon       24284625//24209618//25456834 chr1:32052764-32052765(+) m6A 3'UTR//exon       24284625//24209618//25456834 chr1:32052781-32052782(+) m6A 3'UTR//exon       24284625//24209618//25456834 chr1:32052862-32052863(+) m6A 3'UTR//exon       24284625//24209618//25456834 chr1:32052877-32052878(+) m6A 3'UTR//exon       24284625//24209618//25456834 chr1:32052941-32052942(+) m6A 3'UTR//exon       24284625//24209618 chr1:32053055-32053056(+) m6A 3'UTR//exon       24209618 chr1:32053140-32053141(+) m6A 3'UTR//exon       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TINAGL1	Cytosol HeLa-S3 cells     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TINAGL1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.