Basic Information:

  VIRBase ID:  

VHID00512946

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TSPYL2:  NM_022117     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TSPYL2
miRBase Accession/Entrez ID	MIMAT0001581	64061
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDA1//CINAP//CTCL//DENTT//HRIHFB2216//NP79//SE204//TSPX

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSPYL2	chrX:53111684-53111685(+) m6A CDS//exon       24284625//24209618//24981863 chrX:53111713-53111714(+) m6A CDS//exon       24284625//24209618//24981863 chrX:53112121-53112122(+) m6A CDS//exon//intron       24284625//24209618//24981863 chrX:53112368-53112369(+) m6A CDS//exon//intron       25456834//24981863 chrX:53112426-53112427(+) m6A CDS//exon//intron       - chrX:53112446-53112447(+) m6A CDS//exon//intron       - chrX:53113775-53113776(+) m6A 3'UTR//CDS//exon//intron       26404942 chrX:53113818-53113819(+) m6A exon//intron       26404942 chrX:53114553-53114554(+) m6A exon//intron       24981863//27773535 chrX:53114589-53114590(+) m6A exon//intron       24981863//27773535 chrX:53114816-53114817(+) m6A 3'UTR//CDS//exon       24981863//26404942 chrX:53114877-53114878(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chrX:53114898-53114899(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chrX:53114909-53114910(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chrX:53114945-53114946(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chrX:53114963-53114964(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chrX:53114997-53114998(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960//22608085 chrX:53115047-53115048(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chrX:53115083-53115084(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chrX:53115132-53115133(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chrX:53115144-53115145(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chrX:53115165-53115166(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chrX:53115183-53115184(+) m6A CDS//exon       24209618//24981863//27773535//22575960//22608085 chrX:53115243-53115244(+) m6A CDS//exon       24209618//24981863//27773535//22575960//22608085 chrX:53115378-53115379(+) m6A CDS//exon       24209618//24981863//27773535//22575960//22608085 chrX:53115408-53115409(+) m6A CDS//exon       24209618//24981863//27773535//22575960//22608085 chrX:53115474-53115475(+) m1A CDS//exon       26863196 chrX:53115557-53115558(+) m6A exon//intron       24981863//27773535//22608085 chrX:53115576-53115577(+) m6A exon//intron       24981863//27773535 chrX:53116975-53116976(+) m6A CDS//exon       24981863 chrX:53116993-53116994(+) m6A CDS//exon       24981863 chrX:53117029-53117030(+) m1A CDS//exon       26863196 chrX:53117112-53117113(+) m6A CDS//exon       24981863 chrX:53117457-53117458(+) m6A 3'UTR//exon       24284625 chrX:53117686-53117687(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TSPYL2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TSPYL2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.