Basic Information:

  VIRBase ID:  

VHID00512797

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          EPS15L1:  NR_047665     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	EPS15L1
miRBase Accession/Entrez ID	MIMAT0001581	58513
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	EPS15R

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EPS15L1	chr19:16522643(-) A-I      intronic chr19:16544035(-) A-I      intronic chr19:16544036(-) A-I      intronic chr19:16544044(-) A-I      intronic chr19:16544050(-) A-I      intronic chr19:16544069(-) A-I      intronic chr19:16549497(-) A-I      intronic chr19:16564088(-) A-I      intronic chr19:16564112(-) A-I      intronic chr19:16564115(-) A-I      intronic chr19:16564116(-) A-I      intronic chr19:16507233(-) A-I      intronic chr19:16507240(-) A-I      intronic chr19:16507241(-) A-I      intronic chr19:16507242(-) A-I      intronic chr19:16507274(-) A-I      intronic chr19:16564120(-) A-I      intronic chr19:16507276(-) A-I      intronic chr19:16507278(-) A-I      intronic chr19:16507291(-) A-I      intronic chr19:16507292(-) A-I      intronic chr19:16507299(-) A-I      intronic chr19:16522626(-) A-I      intronic chr19:16506498(-) A-I      intronic chr19:16522635(-) A-I      intronic chr19:16506704(-) A-I      intronic chr19:16522639(-) A-I      intronic chr19:16541659(-) A-I      intronic chr19:16518214(-) A-I      intronic chr19:16518225(-) A-I      intronic chr19:16518391(-) A-I      intronic chr19:16518412(-) A-I      intronic chr19:16519402(-) A-I      intronic chr19:16519408(-) A-I      intronic chr19:16522649(-) A-I      intronic chr19:16522665(-) A-I      intronic chr19:16522709(-) A-I      intronic chr19:16522713(-) A-I      intronic chr19:16522777(-) A-I      intronic chr19:16523309(-) A-I      intronic chr19:16523377(-) A-I      intronic chr19:16523378(-) A-I      intronic chr19:16523403(-) A-I      intronic chr19:16523410(-) A-I      intronic chr19:16527516(-) A-I      intronic chr19:16527525(-) A-I      intronic chr19:16527535(-) A-I      intronic chr19:16527584(-) A-I      intronic chr19:16534114(-) A-I      intronic chr19:16534133(-) A-I      intronic chr19:16534269(-) A-I      intronic chr19:16534281(-) A-I      intronic chr19:16534313(-) A-I      intronic chr19:16535365(-) A-I      intronic chr19:16535377(-) A-I      intronic chr19:16535583(-) A-I      intronic chr19:16535745(-) A-I      intronic chr19:16541878(-) A-I      intronic chr19:16541895(-) A-I      intronic chr19:16542297(-) A-I      intronic chr19:16542342(-) A-I      intronic chr19:16542380(-) A-I      intronic chr19:16542385(-) A-I      intronic chr19:16542988(-) A-I      intronic chr19:16543019(-) A-I      intronic chr19:16543048(-) A-I      intronic chr19:16543081(-) A-I      intronic chr19:16543136(-) A-I      intronic chr19:16543190(-) A-I      intronic chr19:16543195(-) A-I      intronic chr19:16543455(-) A-I      intronic chr19:16543471(-) A-I      intronic chr19:16543507(-) A-I      intronic chr19:16543519(-) A-I      intronic chr19:16543687(-) A-I      intronic chr19:16543689(-) A-I      intronic chr19:16543702(-) A-I      intronic chr19:16543754(-) A-I      intronic chr19:16543780(-) A-I      intronic chr19:16543785(-) A-I      intronic chr19:16543894(-) A-I      intronic chr19:16544076(-) A-I      intronic chr19:16544099(-) A-I      intronic chr19:16544103(-) A-I      intronic chr19:16544533(-) A-I      intronic chr19:16544674(-) A-I      intronic chr19:16544691(-) A-I      intronic chr19:16548981(-) A-I      intronic chr19:16548991(-) A-I      intronic chr19:16548995(-) A-I      intronic chr19:16549001(-) A-I      intronic chr19:16549452(-) A-I      intronic chr19:16549469(-) A-I      intronic chr19:16549495(-) A-I      intronic chr19:16549524(-) A-I      intronic chr19:16549525(-) A-I      intronic chr19:16549542(-) A-I      intronic chr19:16549566(-) A-I      intronic chr19:16549582(-) A-I      intronic chr19:16550419(-) A-I      intronic chr19:16554763(-) A-I      intronic chr19:16554812(-) A-I      intronic chr19:16560930(-) A-I      intronic chr19:16560946(-) A-I      intronic chr19:16561014(-) A-I      intronic chr19:16561352(-) A-I      intronic chr19:16561394(-) A-I      intronic chr19:16561430(-) A-I      intronic chr19:16561819(-) A-I      intronic chr19:16561822(-) A-I      intronic chr19:16561829(-) A-I      intronic chr19:16562405(-) A-I      intronic chr19:16562613(-) A-I      intronic chr19:16562692(-) A-I      intronic chr19:16562698(-) A-I      intronic chr19:16563194(-) A-I      intronic chr19:16564022(-) A-I      intronic chr19:16564051(-) A-I      intronic chr19:16564119(-) A-I      intronic chr19:16564191(-) A-I      intronic chr19:16565828(-) A-I      intronic chr19:16565893(-) A-I      intronic chr19:16566187(-) A-I      intronic chr19:16567006(-) A-I      intronic chr19:16576847(-) A-I      intronic chr19:16576857(-) A-I      intronic chr19:16576908(-) A-I      intronic chr19:16576938(-) A-I      intronic chr19:16576977(-) A-I      intronic chr19:16576978(-) A-I      intronic chr19:16576981(-) A-I      intronic chr19:16577479(-) A-I      intronic chr19:16577496(-) A-I      intronic chr19:16577602(-) A-I      intronic chr19:16577614(-) A-I      intronic chr19:16578052(-) A-I      intronic chr19:16578155(-) A-I      intronic chr19:16578156(-) A-I      intronic chr19:16578193(-) A-I      intronic chr19:16578207(-) A-I      intronic chr19:16579601(-) A-I      intronic chr19:16579602(-) A-I      intronic chr19:16579606(-) A-I      intronic chr19:16579612(-) A-I      intronic chr19:16579627(-) A-I      intronic chr19:16579745(-) A-I      intronic chr19:16579763(-) A-I      intronic chr19:16578233(-) A-I      intronic chr19:16473408(-) A-I      intronic chr19:16473524(-) A-I      intronic chr19:16473534(-) A-I      intronic chr19:16498233(-) A-I      intronic chr19:16498248(-) A-I      intronic chr19:16498254(-) A-I      intronic chr19:16498294(-) A-I      intronic chr19:16498335(-) A-I      intronic chr19:16498449(-) A-I      intronic chr19:16498453(-) A-I      intronic chr19:16498455(-) A-I      intronic chr19:16498992(-) A-I      intronic chr19:16505814(-) A-I      intronic chr19:16505826(-) A-I      intronic chr19:16505972(-) A-I      intronic chr19:16506450(-) A-I      intronic chr19:16506511(-) A-I      intronic chr19:16506512(-) A-I      intronic chr19:16506538(-) A-I      intronic chr19:16506575(-) A-I      intronic chr19:16506583(-) A-I      intronic chr19:16506589(-) A-I      intronic chr19:16506607(-) A-I      intronic chr19:16506608(-) A-I      intronic chr19:16506644(-) A-I      intronic chr19:16506648(-) A-I      intronic chr19:16506673(-) A-I      intronic chr19:16506674(-) A-I      intronic chr19:16506693(-) A-I      intronic chr19:16506807(-) A-I      intronic chr19:16506810(-) A-I      intronic chr19:16506811(-) A-I      intronic chr19:16506819(-) A-I      intronic chr19:16506823(-) A-I      intronic chr19:16506836(-) A-I      intronic chr19:16506855(-) A-I      intronic chr19:16507084(-) A-I      intronic chr19:16507149(-) A-I      intronic chr19:16507170(-) A-I      intronic chr19:16507246(-) A-I      intronic chr19:16507248(-) A-I      intronic chr19:16507249(-) A-I      intronic chr19:16507252(-) A-I      intronic chr19:16507294(-) A-I      intronic chr19:16507339(-) A-I      intronic chr19:16507350(-) A-I      intronic chr19:16507953(-) A-I      intronic chr19:16507968(-) A-I      intronic chr19:16507997(-) A-I      intronic chr19:16508119(-) A-I      intronic chr19:16508157(-) A-I      intronic chr19:16508173(-) A-I      intronic chr19:16510891(-) A-I      intronic chr19:16510912(-) A-I      intronic chr19:16510931(-) A-I      intronic chr19:16510968(-) A-I      intronic chr19:16510982(-) A-I      intronic chr19:16511033(-) A-I      intronic chr19:16511085(-) A-I      intronic chr19:16473610(-) A-I      intronic chr19:16555776(-) A-I      intronic chr19:16555573(-) A-I      intronic chr19:16555666(-) A-I      intronic chr19:16549465(-) A-I      intronic chr19:16507175(-) A-I      intronic chr19:16555694(-) A-I      intronic chr19:16555630(-) A-I      intronic chr19:16549605(-) A-I      intronic chr19:16555682(-) A-I      intronic chr19:16566188(-) A-I      intronic chr19:16523211(-) A-I      intronic chr19:16534189(-) A-I      intronic chr19:16560976(-) A-I      intronic chr19:16560934(-) A-I      intronic chr19:16563216(-) A-I      intronic chr19:16555711(-) A-I      intronic chr19:16564027(-) A-I      intronic chr19:16555686(-) A-I      intronic chr19:16555670(-) A-I      intronic chr19:16507141(-) A-I      intronic chr19:16555781(-) A-I      intronic chr19:16565706(-) A-I      intronic chr19:16555613(-) A-I      intronic chr19:16555676(-) A-I      intronic chr19:16562504(-) A-I      intronic chr19:16555779(-) A-I      intronic chr19:16555568(-) A-I      intronic chr19:16507963(-) A-I      intronic chr19:16564195(-) A-I      intronic chr19:16542341(-) A-I      intronic chr19:16506866(-) A-I      intronic chr19:16549056(-) A-I      intronic chr19:16511036(-) A-I      intronic chr19:16565832(-) A-I      intronic chr19:16565863(-) A-I      intronic chr19:16511026(-) A-I      intronic chr19:16562936(-) A-I      intronic chr19:16560972(-) A-I      intronic chr19:16507244(-) A-I      intronic chr19:16560936(-) A-I      intronic chr19:16542994(-) A-I      intronic chr19:16562510(-) A-I      intronic chr19:16506861(-) A-I      intronic chr19:16575702(-) A-I      intronic chr19:16577631(-) A-I      intronic chr19:16506797(-) A-I      intronic chr19:16508089(-) A-I      intronic chr19:16507211(-) A-I      intronic chr19:16564009(-) A-I      intronic chr19:16564003(-) A-I      intronic chr19:16564075(-) A-I      intronic chr19:16560958(-) A-I      intronic chr19:16565857(-) A-I      intronic chr19:16562838(-) A-I      intronic chr19:16564055(-) A-I      intronic chr19:16566053(-) A-I      intronic chr19:16519354(-) A-I      intronic chr19:16560971(-) A-I      intronic chr19:16549081(-) A-I      intronic chr19:16507213(-) A-I      intronic chr19:16564183(-) A-I      intronic chr19:16507146(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EPS15L1	chr19:16507146(-) A-I intron -    22327324 chr19:16507361(-) A-I intron -    22327324 chr19:16555568(-) A-I intron -    22028664 chr19:16555573(-) A-I intron -    22028664 chr19:16555613(-) A-I intron -    22028664 chr19:16555630(-) A-I intron -    22028664 chr19:16555666(-) A-I intron -    22028664 chr19:16555670(-) A-I intron -    22028664 chr19:16555676(-) A-I intron -    22028664 chr19:16555682(-) A-I intron -    22028664 chr19:16555686(-) A-I intron -    22028664 chr19:16555694(-) A-I intron -    22028664 chr19:16555711(-) A-I intron -    22028664 chr19:16555776(-) A-I intron -    22028664 chr19:16555779(-) A-I intron -    22028664 chr19:16555781(-) A-I intron -    22028664 chr19:16507248(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EPS15L1	chr19:16466166-16466167(-) m6A 3'UTR       27773535 chr19:16466236-16466237(-) m6A 3'UTR       25456834//27773535//27371828 chr19:16466363-16466364(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536 chr19:16466376-16466377(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536 chr19:16466403-16466404(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr19:16466409-16466410(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr19:16466492-16466493(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536 chr19:16466557-16466558(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536 chr19:16466564-16466565(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536 chr19:16466605-16466606(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27371828//27773536 chr19:16468859-16468860(-) m6A intron       - chr19:16468912-16468913(-) m6A intron       - chr19:16468994-16468995(-) m6A intron       - chr19:16469000-16469001(-) m6A intron       - chr19:16469029-16469030(-) m6A intron       - chr19:16469055-16469056(-) m6A intron       - chr19:16472419-16472420(-) m6A 3'UTR//intron       27773535 chr19:16472504-16472505(-) m6A 3'UTR//intron       27773535 chr19:16472758-16472759(-) m6A 3'UTR//CDS       27773535 chr19:16487942-16487943(-) m6A 3'UTR//CDS//intron       27773535 chr19:16487963-16487964(-) m6A 3'UTR//CDS//intron       27773535 chr19:16487988-16487989(-) m6A 3'UTR//CDS//intron       27773535 chr19:16487993-16487994(-) m6A 3'UTR//CDS//intron       27773535 chr19:16493839-16493840(-) m6A 3'UTR//intron       27773535 chr19:16503177-16503178(-) m6A 3'UTR//CDS       27773535 chr19:16503235-16503236(-) m6A 3'UTR//CDS       27773535 chr19:16504773-16504774(-) m6A 3'UTR//CDS       27773535 chr19:16504780-16504781(-) m6A 3'UTR//CDS       27773535 chr19:16506198-16506199(-) m6A 3'UTR//CDS       27773535 chr19:16506205-16506206(-) m6A 3'UTR//CDS       27773535 chr19:16512746-16512747(-) m6A 3'UTR//intron       - chr19:16512777-16512778(-) m6A 3'UTR//intron       - chr19:16513284-16513285(-) m6A 3'UTR//CDS       27773535//27371828//27773536 chr19:16514587-16514588(-) m6A 3'UTR//CDS       24981863//27773535//27371828//27773536 chr19:16514632-16514633(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16514652-16514653(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16514673-16514674(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16515406-16515407(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16515444-16515445(-) m6A 3'UTR//CDS       24981863//27773535//27371828//27773536 chr19:16515468-16515469(-) m6A 3'UTR//CDS       24981863//27773535//27371828//27773536 chr19:16515486-16515487(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16515500-16515501(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16515532-16515533(-) m6A 3'UTR//CDS       24981863//27773535//27371828//27773536 chr19:16515540-16515541(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16524597-16524598(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16524604-16524605(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828//27773536 chr19:16524632-16524633(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828 chr19:16524637-16524638(-) m6A 3'UTR//CDS       24981863//28052920//27773535//27371828 chr19:16528316-16528317(-) m6A exon//intron       27773535 chr19:16532147-16532148(-) m6A 3'UTR//CDS//exon       27773535 chr19:16532213-16532214(-) m6A 3'UTR//CDS//exon       27773535 chr19:16532223-16532224(-) m6A 3'UTR//CDS//exon       27773535 chr19:16532276-16532277(-) m6A 3'UTR//CDS       27773536 chr19:16535898-16535899(-) m6A 3'UTR//CDS       27773536 chr19:16535984-16535985(-) m6A 3'UTR//CDS       24284625//27773535//27371828//27773536 chr19:16536036-16536037(-) m6A 3'UTR//CDS       24284625//27371828//27773536 chr19:16539564-16539565(-) m6A 3'UTR//CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EPS15L1	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: EPS15L1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.