Basic Information:

  VIRBase ID:  

VHID00512750

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RAP2C:  NM_001271187     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RAP2C
miRBase Accession/Entrez ID	MIMAT0001581	57826
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAP2C	chrX:131342288(-) A-I      intronic chrX:131344490(-) A-I      intronic chrX:131344485(-) A-I      intronic chrX:131344484(-) A-I      intronic chrX:131342168(-) A-I      intronic chrX:131344499(-) A-I      intronic chrX:131344548(-) A-I      intronic chrX:131344551(-) A-I      intronic chrX:131344464(-) A-I      intronic chrX:131342240(-) A-I      intronic chrX:131342229(-) A-I      intronic chrX:131342219(-) A-I      intronic chrX:131342200(-) A-I      intronic chrX:131342170(-) A-I      intronic chrX:131342197(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAP2C	chrX:131344650(-) A-I intron -    22327324 chrX:131344608(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAP2C	chrX:131339456-131339457(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:131339536-131339537(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chrX:131339551-131339552(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chrX:131339573-131339574(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chrX:131339609-131339610(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chrX:131348253-131348254(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chrX:131348282-131348283(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chrX:131348314-131348315(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chrX:131348384-131348385(-) m6A CDS//exon       24284625//24981863//27371828//22608085 chrX:131351115-131351116(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//22575960//22608085 chrX:131351126-131351127(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//22575960//22608085 chrX:131351156-131351157(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085 chrX:131351217-131351218(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085 chrX:131351299-131351300(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085 chrX:131351612-131351613(-) Y 5'UTR//intron       26075521 chrX:131351799-131351800(-) m6A 5'UTR//exon//intron       27371828//27773536 chrX:131352018-131352019(-) m6A 5'UTR//intron       24209618//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RAP2C	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RAP2C

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.