Basic Information:

  VIRBase ID:  

VHID00512703

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          FANCM:  NM_001308133     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	FANCM
miRBase Accession/Entrez ID	MIMAT0001581	57697
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAAP250//KIAA1596//POF15//SPGF28

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FANCM	chr14:45648948(+) A-I      intronic chr14:45610854(+) A-I      intronic chr14:45648959(+) A-I      intronic chr14:45646857(+) A-I      intronic chr14:45610380(+) A-I      intronic chr14:45610384(+) A-I      intronic chr14:45611603(+) A-I      intronic chr14:45610897(+) A-I      intronic chr14:45635551(+) A-I      intronic chr14:45661766(+) A-I      intronic chr14:45613147(+) A-I      intronic chr14:45613142(+) A-I      intronic chr14:45612658(+) A-I      intronic chr14:45612559(+) A-I      intronic chr14:45612509(+) A-I      intronic chr14:45616893(+) A-I      intronic chr14:45612396(+) A-I      intronic chr14:45616024(+) A-I      intronic chr14:45610364(+) A-I      intronic chr14:45635602(+) A-I      intronic chr14:45659060(+) A-I      intronic chr14:45654094(+) A-I      intronic chr14:45654077(+) A-I      intronic chr14:45654046(+) A-I      intronic chr14:45617279(+) A-I      intronic chr14:45654038(+) A-I      intronic chr14:45616023(+) A-I      intronic chr14:45617280(+) A-I      intronic chr14:45617306(+) A-I      intronic chr14:45620908(+) A-I      intronic chr14:45621306(+) A-I      intronic chr14:45621311(+) A-I      intronic chr14:45621517(+) A-I      intronic chr14:45623497(+) A-I      intronic chr14:45661934(+) A-I      intronic chr14:45623502(+) A-I      intronic chr14:45653729(+) A-I      intronic chr14:45653718(+) A-I      intronic chr14:45649848(+) A-I      intronic chr14:45649802(+) A-I      intronic chr14:45649754(+) A-I      intronic chr14:45649714(+) A-I      intronic chr14:45654132(+) A-I      intronic chr14:45654116(+) A-I      intronic chr14:45617198(+) A-I      intronic chr14:45611701(+) A-I      intronic chr14:45649713(+) A-I      intronic chr14:45609982(+) A-I      intronic chr14:45639654(+) A-I      intronic chr14:45610929(+) A-I      intronic chr14:45649689(+) A-I      intronic chr14:45612619(+) A-I      intronic chr14:45616566(+) A-I      intronic chr14:45616020(+) A-I      intronic chr14:45648894(+) A-I      intronic chr14:45615818(+) A-I      intronic chr14:45621062(+) A-I      intronic chr14:45648865(+) A-I      intronic chr14:45648826(+) A-I      intronic chr14:45648287(+) A-I      intronic chr14:45609179(+) A-I      intronic chr14:45635415(+) A-I      intronic chr14:45635880(+) A-I      intronic chr14:45648281(+) A-I      intronic chr14:45648138(+) A-I      intronic chr14:45643443(+) A-I      intronic chr14:45649750(+) A-I      intronic chr14:45639520(+) A-I      intronic chr14:45639504(+) A-I      intronic chr14:45635936(+) A-I      intronic chr14:45635852(+) A-I      intronic chr14:45617139(+) A-I      intronic chr14:45610344(+) A-I      intronic chr14:45635711(+) A-I      intronic chr14:45635429(+) A-I      intronic chr14:45633278(+) A-I      intronic chr14:45633217(+) A-I      intronic chr14:45639602(+) A-I      intronic chr14:45639575(+) A-I      intronic chr14:45624923(+) A-I      intronic chr14:45616900(+) A-I      intronic chr14:45610337(+) A-I      intronic chr14:45615414(+) A-I      intronic chr14:45610167(+) A-I      intronic chr14:45610334(+) A-I      intronic chr14:45615399(+) A-I      intronic chr14:45610092(+) A-I      intronic chr14:45615376(+) A-I      intronic chr14:45610892(+) A-I      intronic chr14:45610090(+) A-I      intronic chr14:45610162(+) A-I      intronic chr14:45610328(+) A-I      intronic chr14:45611566(+) A-I      intronic chr14:45615297(+) A-I      intronic chr14:45616895(+) A-I      intronic chr14:45660197(+) A-I      intronic chr14:45660188(+) A-I      intronic chr14:45616695(+) A-I      intronic chr14:45635832(+) A-I      intronic chr14:45616669(+) A-I      intronic chr14:45615287(+) A-I      intronic chr14:45661767(+) A-I      intronic chr14:45613169(+) A-I      intronic chr14:45624882(+) A-I      intronic chr14:45654190(+) A-I      intronic chr14:45624914(+) A-I      intronic chr14:45612482(+) A-I      intronic chr14:45616706(+) A-I      intronic chr14:45624922(+) A-I      intronic chr14:45648218(+) A-I      intronic chr14:45621312(+) A-I      intronic chr14:45649753(+) A-I      intronic chr14:45616841(+) A-I      intronic chr14:45635782(+) A-I      intronic chr14:45611610(+) A-I      intronic chr14:45611691(+) A-I      intronic chr14:45609456(+) A-I      intronic chr14:45621332(+) A-I      intronic chr14:45609972(+) A-I      intronic chr14:45635544(+) A-I      intronic chr14:45610976(+) A-I      intronic chr14:45635763(+) A-I      intronic chr14:45610236(+) A-I      intronic chr14:45610411(+) A-I      intronic chr14:45659103(+) A-I      intronic chr14:45610973(+) A-I      intronic chr14:45660113(+) A-I      intronic chr14:45659042(+) A-I      intronic chr14:45616621(+) A-I      intronic chr14:45610993(+) A-I      intronic chr14:45612445(+) A-I      intronic chr14:45653754(+) A-I      intronic chr14:45610072(+) A-I      intronic chr14:45614866(+) A-I      intronic chr14:45609449(+) A-I      intronic chr14:45618845(+) A-I      intronic chr14:45612627(+) A-I      intronic chr14:45610329(+) A-I      intronic chr14:45608925(+) A-I      intronic chr14:45611584(+) A-I      intronic chr14:45648967(+) A-I      intronic chr14:45635452(+) A-I      intronic chr14:45610932(+) A-I      intronic chr14:45649874(+) A-I      intronic chr14:45635728(+) A-I      intronic chr14:45610258(+) A-I      intronic chr14:45661933(+) A-I      intronic chr14:45664135(+) A-I      intronic chr14:45624747(+) A-I      intronic chr14:45635476(+) A-I      intronic chr14:45609988(+) A-I      intronic chr14:45610144(+) A-I      intronic chr14:45660183(+) A-I      intronic chr14:45610121(+) A-I      intronic chr14:45617215(+) A-I      intronic chr14:45653793(+) A-I      intronic chr14:45611649(+) A-I      intronic chr14:45624754(+) A-I      intronic chr14:45649859(+) A-I      intronic chr14:45609466(+) A-I      intronic chr14:45659077(+) A-I      intronic chr14:45635414(+) A-I      intronic chr14:45610370(+) A-I      intronic chr14:45648259(+) A-I      intronic chr14:45615365(+) A-I      intronic chr14:45610922(+) A-I      intronic chr14:45617040(+) A-I      intronic chr14:45635907(+) A-I      intronic chr14:45609966(+) A-I      intronic chr14:45639650(+) A-I      intronic chr14:45610313(+) A-I      intronic chr14:45617177(+) A-I      intronic chr14:45639515(+) A-I      intronic chr14:45631403(+) A-I      intronic chr14:45610259(+) A-I      intronic chr14:45649669(+) A-I      intronic chr14:45653777(+) A-I      intronic chr14:45648147(+) A-I      intronic chr14:45653814(+) A-I      intronic chr14:45610038(+) A-I      intronic chr14:45616842(+) A-I      intronic chr14:45635845(+) A-I      intronic chr14:45610376(+) A-I      intronic chr14:45661796(+) A-I      intronic chr14:45639668(+) A-I      intronic chr14:45639649(+) A-I      intronic chr14:45613036(+) A-I      intronic chr14:45609541(+) A-I      intronic chr14:45634497(+) A-I      intronic chr14:45649698(+) A-I      intronic chr14:45621467(+) A-I      intronic chr14:45610314(+) A-I      intronic chr14:45610152(+) A-I      intronic chr14:45610958(+) A-I      intronic chr14:45649749(+) A-I      intronic chr14:45616855(+) A-I      intronic chr14:45609061(+) A-I      intronic chr14:45654106(+) A-I      intronic chr14:45610893(+) A-I      intronic chr14:45648385(+) A-I      intronic chr14:45617146(+) A-I      intronic chr14:45609994(+) A-I      intronic chr14:45661921(+) A-I      intronic chr14:45617385(+) A-I      intronic chr14:45609544(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FANCM	chr14:45659042(+) A-I intron -    22327324 chr14:45660183(+) A-I intron -    22327324 chr14:45608925(+) A-G intron -    22484847 chr14:45609966(+) A-G intron -    22484847 chr14:45610329(+) A-G intron -    22484847 chr14:45649887(+) C-A intron -    22484847 chr14:45659042(+) A-G intron -    22484847 chr14:45660183(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FANCM	chr14:45605153-45605154(+) m6A 5'UTR       24981863//22608085 chr14:45605169-45605170(+) m6A 5'UTR       24981863//22608085 chr14:45605297-45605298(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr14:45605318-45605319(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr14:45605511-45605512(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr14:45605575-45605576(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr14:45605585-45605586(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr14:45605665-45605666(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr14:45644415-45644416(+) m6A CDS       24981863//27773535//22608085 chr14:45644479-45644480(+) m6A CDS       24981863//27773535//22608085 chr14:45644494-45644495(+) m6A CDS       24981863//27773535//22608085 chr14:45644634-45644635(+) m6A CDS       24981863//22608085 chr14:45644654-45644655(+) m6A CDS       24981863//22608085 chr14:45644713-45644714(+) m6A CDS       24981863//22608085 chr14:45644870-45644871(+) m6A CDS       22608085 chr14:45644965-45644966(+) m6A CDS       24981863//22608085 chr14:45644973-45644974(+) m6A CDS       24981863//22608085 chr14:45645217-45645218(+) m6A CDS       24981863//22608085 chr14:45645297-45645298(+) m6A CDS       24981863//22608085 chr14:45645414-45645415(+) m6A CDS       24284625//24981863//22608085 chr14:45645444-45645445(+) m6A CDS       24284625//24981863//22608085 chr14:45645449-45645450(+) m6A CDS       24284625//24981863//22608085 chr14:45645499-45645500(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:45645510-45645511(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:45645523-45645524(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:45645697-45645698(+) m6A CDS       24981863//22608085 chr14:45645718-45645719(+) m6A CDS       24981863//22608085 chr14:45645833-45645834(+) m6A CDS       24981863//22608085 chr14:45645990-45645991(+) m6A CDS       24981863//22608085 chr14:45645999-45646000(+) m6A CDS       24981863//22608085 chr14:45646034-45646035(+) m6A CDS       22608085 chr14:45646062-45646063(+) m6A CDS       22608085 chr14:45657060-45657061(+) m6A CDS       22608085 chr14:45657070-45657071(+) m6A CDS       22608085 chr14:45657076-45657077(+) m6A CDS       22608085 chr14:45658012-45658013(+) m6A CDS       22608085 chr14:45658022-45658023(+) m6A CDS       22608085 chr14:45658151-45658152(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:45658186-45658187(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:45658257-45658258(+) m6A CDS       24284625//24981863//22608085 chr14:45658317-45658318(+) m6A CDS       24284625//24981863//22608085 chr14:45658329-45658330(+) m6A CDS       24284625//24981863//22608085 chr14:45658420-45658421(+) m6A CDS       24284625//24981863//22608085 chr14:45658464-45658465(+) m6A CDS       24284625//24981863//27773535//22608085 chr14:45658471-45658472(+) m6A CDS       24284625//24981863//27773535//22608085 chr14:45658536-45658537(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr14:45664691-45664692(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr14:45665430-45665431(+) m6A CDS       24981863//22608085 chr14:45665446-45665447(+) m6A CDS       24981863//22608085 chr14:45665463-45665464(+) m6A CDS       24981863//22608085 chr14:45665485-45665486(+) m6A CDS       24981863//22608085 chr14:45667849-45667850(+) m6A CDS//exon//intron       22608085 chr14:45667872-45667873(+) m6A CDS//exon//intron       22608085 chr14:45667950-45667951(+) m6A CDS//exon       24209618//24981863//22608085 chr14:45667970-45667971(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr14:45667985-45667986(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr14:45669192-45669193(+) m6A 3'UTR//CDS       24981863//22608085 chr14:45669240-45669241(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FANCM	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: FANCM

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.