Basic Information:

  VIRBase ID:  

VHID00512538

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NDRG3:  NM_022477     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NDRG3
miRBase Accession/Entrez ID	MIMAT0001581	57446
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NDRG3	chr20:35301981(-) A-I      intronic chr20:35301988(-) A-I      intronic chr20:35338967(-) A-I      intronic chr20:35338986(-) A-I      intronic chr20:35341361(-) A-I      intronic chr20:35341367(-) A-I      intronic chr20:35341383(-) A-I      intronic chr20:35285791(-) A-I      intronic chr20:35340937(-) A-I      intronic chr20:35341350(-) A-I      intronic chr20:35341390(-) A-I      intronic chr20:35352283(-) A-I      intronic chr20:35352288(-) A-I      intronic chr20:35352289(-) A-I      intronic chr20:35352292(-) A-I      intronic chr20:35340923(-) A-I      intronic chr20:35340922(-) A-I      intronic chr20:35339053(-) A-I      intronic chr20:35339044(-) A-I      intronic chr20:35338632(-) A-I      intronic chr20:35338603(-) A-I      intronic chr20:35338602(-) A-I      intronic chr20:35337354(-) A-I      intronic chr20:35335098(-) A-I      intronic chr20:35335031(-) A-I      intronic chr20:35334420(-) A-I      intronic chr20:35334374(-) A-I      intronic chr20:35334347(-) A-I      intronic chr20:35302438(-) A-I      intronic chr20:35302813(-) A-I      intronic chr20:35303583(-) A-I      intronic chr20:35303659(-) A-I      intronic chr20:35303866(-) A-I      intronic chr20:35303886(-) A-I      intronic chr20:35303928(-) A-I      intronic chr20:35303930(-) A-I      intronic chr20:35304020(-) A-I      intronic chr20:35304021(-) A-I      intronic chr20:35306851(-) A-I      intronic chr20:35307000(-) A-I      intronic chr20:35307555(-) A-I      intronic chr20:35307557(-) A-I      intronic chr20:35307558(-) A-I      intronic chr20:35307566(-) A-I      intronic chr20:35307648(-) A-I      intronic chr20:35308285(-) A-I      intronic chr20:35308300(-) A-I      intronic chr20:35308699(-) A-I      intronic chr20:35309796(-) A-I      intronic chr20:35309917(-) A-I      intronic chr20:35334955(-) A-I      intronic chr20:35285699(-) A-I      intronic chr20:35300093(-) A-I      intronic chr20:35300959(-) A-I      intronic chr20:35368282(-) A-I      intronic chr20:35300975(-) A-I      intronic chr20:35301108(-) A-I      intronic chr20:35301169(-) A-I      intronic chr20:35302010(-) A-I      intronic chr20:35302012(-) A-I      intronic chr20:35302013(-) A-I      intronic chr20:35368261(-) A-I      intronic chr20:35358860(-) A-I      intronic chr20:35358856(-) A-I      intronic chr20:35358797(-) A-I      intronic chr20:35358790(-) A-I      intronic chr20:35309920(-) A-I      intronic chr20:35356186(-) A-I      intronic chr20:35353849(-) A-I      intronic chr20:35352341(-) A-I      intronic chr20:35352329(-) A-I      intronic chr20:35348722(-) A-I      intronic chr20:35348714(-) A-I      intronic chr20:35348346(-) A-I      intronic chr20:35343198(-) A-I      intronic chr20:35302036(-) A-I      intronic chr20:35343195(-) A-I      intronic chr20:35343194(-) A-I      intronic chr20:35343193(-) A-I      intronic chr20:35342721(-) A-I      intronic chr20:35329175(-) A-I      intronic chr20:35329683(-) A-I      intronic chr20:35329710(-) A-I      intronic chr20:35356194(-) A-I      intronic chr20:35329748(-) A-I      intronic chr20:35341192(-) A-I      intronic chr20:35329774(-) A-I      intronic chr20:35341172(-) A-I      intronic chr20:35332668(-) A-I      intronic chr20:35334188(-) A-I      intronic chr20:35309927(-) A-I      intronic chr20:35310249(-) A-I      intronic chr20:35310349(-) A-I      intronic chr20:35313166(-) A-I      intronic chr20:35313169(-) A-I      intronic chr20:35313792(-) A-I      intronic chr20:35313913(-) A-I      intronic chr20:35313933(-) A-I      intronic chr20:35313937(-) A-I      intronic chr20:35313993(-) A-I      intronic chr20:35314220(-) A-I      intronic chr20:35314240(-) A-I      intronic chr20:35314330(-) A-I      intronic chr20:35314331(-) A-I      intronic chr20:35315541(-) A-I      intronic chr20:35317367(-) A-I      intronic chr20:35318303(-) A-I      intronic chr20:35334233(-) A-I      intronic chr20:35318324(-) A-I      intronic chr20:35318326(-) A-I      intronic chr20:35318328(-) A-I      intronic chr20:35320069(-) A-I      intronic chr20:35341127(-) A-I      intronic chr20:35341120(-) A-I      intronic chr20:35320715(-) A-I      intronic chr20:35320723(-) A-I      intronic chr20:35324964(-) A-I      intronic chr20:35324965(-) A-I      intronic chr20:35324969(-) A-I      intronic chr20:35326763(-) A-I      intronic chr20:35326886(-) A-I      intronic chr20:35328332(-) A-I      intronic chr20:35328341(-) A-I      intronic chr20:35328455(-) A-I      intronic chr20:35300001(-) A-I      intronic chr20:35299961(-) A-I      intronic chr20:35298027(-) A-I      intronic chr20:35288026(-) A-I      intronic chr20:35287803(-) A-I      intronic chr20:35368833(-) A-I      intronic chr20:35368839(-) A-I      intronic chr20:35368855(-) A-I      intronic chr20:35286667(-) A-I      intronic chr20:35286658(-) A-I      intronic chr20:35280768(-) A-I      3'UTR chr20:35280759(-) A-I      3'UTR chr20:35280808(-) A-I      3'UTR chr20:35280810(-) A-I      3'UTR chr20:35280812(-) A-I      3'UTR chr20:35280734(-) A-I      3'UTR chr20:35349339(-) A-I      intronic chr20:35309876(-) A-I      intronic chr20:35330062(-) A-I      intronic chr20:35330183(-) A-I      intronic chr20:35366902(-) A-I      intronic chr20:35359258(-) A-I      intronic chr20:35326645(-) A-I      intronic chr20:35296491(-) A-I      intronic chr20:35295374(-) A-I      intronic chr20:35296513(-) A-I      intronic chr20:35300969(-) A-I      intronic chr20:35344454(-) A-I      intronic chr20:35348606(-) A-I      intronic chr20:35286672(-) A-I      intronic chr20:35317566(-) A-I      intronic chr20:35329288(-) A-I      intronic chr20:35335066(-) A-I      intronic chr20:35315426(-) A-I      intronic chr20:35340828(-) A-I      intronic chr20:35340913(-) A-I      intronic chr20:35326899(-) A-I      intronic chr20:35305045(-) A-I      intronic chr20:35314288(-) A-I      intronic chr20:35338993(-) A-I      intronic chr20:35359202(-) A-I      intronic chr20:35358805(-) A-I      intronic chr20:35303390(-) A-I      intronic chr20:35330088(-) A-I      intronic chr20:35364331(-) A-I      intronic chr20:35302349(-) A-I      intronic chr20:35361455(-) A-I      intronic chr20:35303735(-) A-I      intronic chr20:35326620(-) A-I      intronic chr20:35301915(-) A-I      intronic chr20:35366786(-) A-I      intronic chr20:35329452(-) A-I      intronic chr20:35297729(-) A-I      intronic chr20:35329723(-) A-I      intronic chr20:35309847(-) A-I      intronic chr20:35349845(-) A-I      intronic chr20:35320900(-) A-I      intronic chr20:35287472(-) A-I      intronic chr20:35335164(-) A-I      intronic chr20:35341226(-) A-I      intronic chr20:35323331(-) A-I      intronic chr20:35348803(-) A-I      intronic chr20:35326883(-) A-I      intronic chr20:35297739(-) A-I      intronic chr20:35330145(-) A-I      intronic chr20:35303093(-) A-I      intronic chr20:35302340(-) A-I      intronic chr20:35308086(-) A-I      intronic chr20:35340453(-) A-I      intronic chr20:35329689(-) A-I      intronic chr20:35307007(-) A-I      intronic chr20:35326837(-) A-I      intronic chr20:35305079(-) A-I      intronic chr20:35296456(-) A-I      intronic chr20:35303573(-) A-I      intronic chr20:35308018(-) A-I      intronic chr20:35355497(-) A-I      intronic chr20:35301466(-) A-I      intronic chr20:35302744(-) A-I      intronic chr20:35335152(-) A-I      intronic chr20:35297796(-) A-I      intronic chr20:35295241(-) A-I      intronic chr20:35332106(-) A-I      intronic chr20:35280653(-) A-I      3'UTR chr20:35280733(-) A-I      3'UTR chr20:35280753(-) A-I      3'UTR chr20:35280636(-) A-I      3'UTR chr20:35280769(-) A-I      3'UTR chr20:35280581(-) A-I      3'UTR chr20:35280704(-) A-I      3'UTR chr20:35280694(-) A-I      3'UTR chr20:35280559(-) A-I      3'UTR chr20:35280633(-) A-I      3'UTR chr20:35305147(-) A-I      intronic chr20:35358853(-) A-I      intronic chr20:35332101(-) A-I      intronic chr20:35285728(-) A-I      intronic chr20:35309806(-) A-I      intronic chr20:35295703(-) A-I      intronic chr20:35349832(-) A-I      intronic chr20:35303641(-) A-I      intronic chr20:35330154(-) A-I      intronic chr20:35359166(-) A-I      intronic chr20:35329826(-) A-I      intronic chr20:35304062(-) A-I      intronic chr20:35301364(-) A-I      intronic chr20:35296639(-) A-I      intronic chr20:35304068(-) A-I      intronic chr20:35296479(-) A-I      intronic chr20:35310233(-) A-I      intronic chr20:35306904(-) A-I      intronic chr20:35335185(-) A-I      intronic chr20:35298139(-) A-I      intronic chr20:35297350(-) A-I      intronic chr20:35324783(-) A-I      intronic chr20:35338941(-) A-I      intronic chr20:35308708(-) A-I      intronic chr20:35353888(-) A-I      intronic chr20:35324749(-) A-I      intronic chr20:35321259(-) A-I      intronic chr20:35340896(-) A-I      intronic chr20:35303206(-) A-I      intronic chr20:35331319(-) A-I      intronic chr20:35309873(-) A-I      intronic chr20:35315441(-) A-I      intronic chr20:35321356(-) A-I      intronic chr20:35310192(-) A-I      intronic chr20:35302251(-) A-I      intronic chr20:35308045(-) A-I      intronic chr20:35327413(-) A-I      intronic chr20:35301870(-) A-I      intronic chr20:35296523(-) A-I      intronic chr20:35326011(-) A-I      intronic chr20:35342725(-) A-I      intronic chr20:35301906(-) A-I      intronic chr20:35321442(-) A-I      intronic chr20:35320899(-) A-I      intronic chr20:35339025(-) A-I      intronic chr20:35302424(-) A-I      intronic chr20:35301989(-) A-I      intronic chr20:35335099(-) A-I      intronic chr20:35326748(-) A-I      intronic chr20:35307491(-) A-I      intronic chr20:35335181(-) A-I      intronic chr20:35324692(-) A-I      intronic chr20:35341167(-) A-I      intronic chr20:35297765(-) A-I      intronic chr20:35287768(-) A-I      intronic chr20:35330066(-) A-I      intronic chr20:35301446(-) A-I      intronic chr20:35341241(-) A-I      intronic chr20:35303645(-) A-I      intronic chr20:35333505(-) A-I      intronic chr20:35366343(-) A-I      intronic chr20:35329697(-) A-I      intronic chr20:35349379(-) A-I      intronic chr20:35304075(-) A-I      intronic chr20:35338472(-) A-I      intronic chr20:35285767(-) A-I      intronic chr20:35302687(-) A-I      intronic chr20:35357218(-) A-I      intronic chr20:35344360(-) A-I      intronic chr20:35341137(-) A-I      intronic chr20:35366350(-) A-I      intronic chr20:35331064(-) A-I      intronic chr20:35341136(-) A-I      intronic chr20:35326497(-) A-I      intronic chr20:35302708(-) A-I      intronic chr20:35297771(-) A-I      intronic chr20:35348352(-) A-I      intronic chr20:35320864(-) A-I      intronic chr20:35320033(-) A-I      intronic chr20:35324779(-) A-I      intronic chr20:35348764(-) A-I      intronic chr20:35372432(-) A-I      intronic chr20:35285646(-) A-I      intronic chr20:35303340(-) A-I      intronic chr20:35320843(-) A-I      intronic chr20:35340424(-) A-I      intronic chr20:35301149(-) A-I      intronic chr20:35332750(-) A-I      intronic chr20:35329818(-) A-I      intronic chr20:35326538(-) A-I      intronic chr20:35326894(-) A-I      intronic chr20:35286738(-) A-I      intronic chr20:35347359(-) A-I      intronic chr20:35295333(-) A-I      intronic chr20:35347363(-) A-I      intronic chr20:35327483(-) A-I      intronic chr20:35326564(-) A-I      intronic chr20:35331985(-) A-I      intronic chr20:35335083(-) A-I      intronic chr20:35320803(-) A-I      intronic chr20:35354526(-) A-I      intronic chr20:35303400(-) A-I      intronic chr20:35329219(-) A-I      intronic chr20:35302444(-) A-I      intronic chr20:35307541(-) A-I      intronic chr20:35329341(-) A-I      intronic chr20:35367397(-) A-I      intronic chr20:35301539(-) A-I      intronic chr20:35344421(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NDRG3	chr20:35280767-35280768(-) m6A 3'UTR       27773535 chr20:35280809-35280810(-) m6A 3'UTR       27773535 chr20:35280842-35280843(-) m6A 3'UTR       27773535 chr20:35280926-35280927(-) m6A 3'UTR       27773535 chr20:35281060-35281061(-) m6A 3'UTR       24981863//27773535 chr20:35281089-35281090(-) m6A 3'UTR       24981863//27773535 chr20:35281122-35281123(-) m6A 3'UTR       24981863 chr20:35281147-35281148(-) m6A 3'UTR       24981863 chr20:35281736-35281737(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:35281805-35281806(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:35281844-35281845(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:35281902-35281903(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:35281942-35281943(-) m6A CDS       24284625//24981863//27773535//22608085 chr20:35281953-35281954(-) m6A CDS       24284625//24981863//27773535//22608085 chr20:35281987-35281988(-) m6A CDS       24284625//27773535 chr20:35282065-35282066(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NDRG3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NDRG3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.