Basic Information:

  VIRBase ID:  

VHID00512477

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLC39A10:  NM_001127257     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLC39A10
miRBase Accession/Entrez ID	MIMAT0001581	57181
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	LZT-Hs2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC39A10	chr2:196527233(+) A-I      intronic chr2:196533521(+) A-I      intronic chr2:196539131(+) A-I      intronic chr2:196537075(+) A-I      intronic chr2:196527200(+) A-I      intronic chr2:196536958(+) A-I      intronic chr2:196529657(+) A-I      intronic chr2:196534629(+) A-I      intronic chr2:196533597(+) A-I      intronic chr2:196531324(+) A-I      intronic chr2:196531312(+) A-I      intronic chr2:196529947(+) A-I      intronic chr2:196529792(+) A-I      intronic chr2:196536934(+) A-I      intronic chr2:196534729(+) A-I      intronic chr2:196529697(+) A-I      intronic chr2:196531300(+) A-I      intronic chr2:196529645(+) A-I      intronic chr2:196529660(+) A-I      intronic chr2:196542079(+) A-I      intronic chr2:196531308(+) A-I      intronic chr2:196531395(+) A-I      intronic chr2:196531421(+) A-I      intronic chr2:196533625(+) A-I      intronic chr2:196533692(+) A-I      intronic chr2:196533705(+) A-I      intronic chr2:196534721(+) A-I      intronic chr2:196534730(+) A-I      intronic chr2:196534824(+) A-I      intronic chr2:196534733(+) A-I      intronic chr2:196536959(+) A-I      intronic chr2:196534789(+) A-I      intronic chr2:196534804(+) A-I      intronic chr2:196527020(+) A-I      intronic chr2:196527156(+) A-I      intronic chr2:196538013(+) A-I      intronic chr2:196540418(+) A-I      intronic chr2:196542093(+) A-I      intronic chr2:196542105(+) A-I      intronic chr2:196568421(+) A-I      intronic chr2:196568631(+) A-I      intronic chr2:196538086(+) A-I      intronic chr2:196531233(+) A-I      intronic chr2:196533557(+) A-I      intronic chr2:196527147(+) A-I      intronic chr2:196542554(+) A-I      intronic chr2:196534460(+) A-I      intronic chr2:196534630(+) A-I      intronic chr2:196542107(+) A-I      intronic chr2:196542153(+) A-I      intronic chr2:196531257(+) A-I      intronic chr2:196531460(+) A-I      intronic chr2:196578790(+) A-I      intronic chr2:196537137(+) A-I      intronic chr2:196537052(+) A-I      intronic chr2:196537044(+) A-I      intronic chr2:196542746(+) A-I      intronic chr2:196536984(+) A-I      intronic chr2:196542108(+) A-I      intronic chr2:196527189(+) A-I      intronic chr2:196526186(+) A-I      intronic chr2:196527023(+) A-I      intronic chr2:196554736(+) A-I      intronic chr2:196540229(+) A-I      intronic chr2:196566429(+) A-I      intronic chr2:196578840(+) A-I      intronic chr2:196526182(+) A-I      intronic chr2:196542006(+) A-I      intronic chr2:196534762(+) A-I      intronic chr2:196536874(+) A-I      intronic chr2:196542168(+) A-I      intronic chr2:196533679(+) A-I      intronic chr2:196554700(+) A-I      intronic chr2:196531447(+) A-I      intronic chr2:196530081(+) A-I      intronic chr2:196542734(+) A-I      intronic chr2:196540234(+) A-I      intronic chr2:196531448(+) A-I      intronic chr2:196531283(+) A-I      intronic chr2:196538119(+) A-I      intronic chr2:196536980(+) A-I      intronic chr2:196527132(+) A-I      intronic chr2:196537045(+) A-I      intronic chr2:196537027(+) A-I      intronic chr2:196536967(+) A-I      intronic chr2:196529725(+) A-I      intronic chr2:196530087(+) A-I      intronic chr2:196531322(+) A-I      intronic chr2:196534541(+) A-I      intronic chr2:196538000(+) A-I      intronic chr2:196566437(+) A-I      intronic chr2:196539102(+) A-I      intronic chr2:196539141(+) A-I      intronic chr2:196538144(+) A-I      intronic chr2:196529651(+) A-I      intronic chr2:196529888(+) A-I      intronic chr2:196534682(+) A-I      intronic chr2:196529793(+) A-I      intronic chr2:196554832(+) A-I      intronic chr2:196537995(+) A-I      intronic chr2:196529962(+) A-I      intronic chr2:196529698(+) A-I      intronic chr2:196534736(+) A-I      intronic chr2:196580157(+) A-I      intronic chr2:196531348(+) A-I      intronic chr2:196554739(+) A-I      intronic chr2:196593747(+) A-I      intronic chr2:196554822(+) A-I      intronic chr2:196542159(+) A-I      intronic chr2:196542097(+) A-I      intronic chr2:196530061(+) A-I      intronic chr2:196536981(+) A-I      intronic chr2:196527209(+) A-I      intronic chr2:196542693(+) A-I      intronic chr2:196536996(+) A-I      intronic chr2:196536972(+) A-I      intronic chr2:196531295(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC39A10	chr2:196536874(+) A-G intron -    22484847 chr2:196536984(+) A-G intron -    22484847 chr2:196536996(+) A-G intron -    22484847 chr2:196537027(+) A-G intron -    22484847 chr2:196537045(+) A-G intron -    22484847 chr2:196542006(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC39A10	chr2:196521657-196521658(+) m6A 5'UTR//intron       - chr2:196521676-196521677(+) m6A 5'UTR//intron       - chr2:196521694-196521695(+) m6A 5'UTR//intron       - chr2:196521857-196521858(+) m6A 5'UTR//intron       22575960 chr2:196536439-196536440(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr2:196544849-196544850(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr2:196544879-196544880(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr2:196544963-196544964(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545017-196545018(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545028-196545029(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545186-196545187(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545214-196545215(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545240-196545241(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545272-196545273(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545401-196545402(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545414-196545415(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545423-196545424(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545431-196545432(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545446-196545447(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545542-196545543(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr2:196545569-196545570(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr2:196545644-196545645(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr2:196545677-196545678(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr2:196573486-196573487(+) m6A 3'UTR//CDS//exon       22575960 chr2:196573528-196573529(+) m6A 3'UTR//CDS//exon       22575960 chr2:196573558-196573559(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr2:196578161-196578162(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr2:196578179-196578180(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196578184-196578185(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196578232-196578233(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196581362-196581363(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196581401-196581402(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581406-196581407(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581411-196581412(+) Cm 3'UTR//CDS//exon       - chr2:196581480-196581481(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581558-196581559(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr2:196581563-196581564(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr2:196599990-196599991(+) m6A 3'UTR       24981863//22608085 chr2:196599999-196600000(+) m6A 3'UTR       24981863//22608085 chr2:196600024-196600025(+) m6A 3'UTR       24981863//22608085 chr2:196600049-196600050(+) m6A 3'UTR       24981863//22608085 chr2:196600073-196600074(+) m6A 3'UTR       24981863//22608085 chr2:196600104-196600105(+) m6A 3'UTR       24981863//22608085 chr2:196600123-196600124(+) m6A 3'UTR       24981863//22608085 chr2:196600145-196600146(+) m6A 3'UTR       24981863//22608085 chr2:196600156-196600157(+) m6A 3'UTR       24981863//22608085 chr2:196600252-196600253(+) m6A 3'UTR       24981863//22575960//22608085 chr2:196600266-196600267(+) m6A 3'UTR       24981863//22575960//22608085 chr2:196600274-196600275(+) m6A 3'UTR       22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC39A10	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC39A10

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.