Basic Information:

  VIRBase ID:  

VHID00512419

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PNPLA2:  NM_020376     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PNPLA2
miRBase Accession/Entrez ID	MIMAT0001581	57104
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	1110001C14Rik//ATGL//FP17548//iPLA2zeta//PEDF-R//TTS-2.2//TTS2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PNPLA2	chr11:818938-818939(+) m6A 5'UTR       24981863 chr11:818952-818953(+) m6A 5'UTR       24981863 chr11:819596-819597(+) m6A 5'UTR       24209618//25456834//24981863//27371828 chr11:819620-819621(+) m6A 5'UTR       24209618//25456834//24981863//27371828 chr11:819691-819692(+) m6A 5'UTR       24284625//24209618//24981863//27371828 chr11:819743-819744(+) m6A CDS       24284625 chr11:820933-820934(+) m6A 5'UTR//exon//intron       - chr11:821055-821056(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr11:821095-821096(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr11:821169-821170(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr11:821191-821192(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr11:821235-821236(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr11:822421-822422(+) m6A 5'UTR//CDS//exon       - chr11:822448-822449(+) m6A 5'UTR//CDS//exon       - chr11:822499-822500(+) m6A 5'UTR//CDS//exon       22575960 chr11:823595-823596(+) m6A 5'UTR//exon//intron       24284625 chr11:823663-823664(+) m6A 5'UTR//exon//intron       24284625 chr11:823702-823703(+) m6A 5'UTR//CDS//exon       24284625 chr11:823756-823757(+) m6A 5'UTR//CDS//exon       24284625 chr11:823762-823763(+) m6A 5'UTR//CDS//exon       24284625 chr11:824027-824028(+) m6A 5'UTR//CDS//exon       - chr11:824345-824346(+) m6A CDS//exon       - chr11:824764-824765(+) m6A CDS//exon       24284625//22575960 chr11:824863-824864(+) m6A 3'UTR//CDS//exon       24284625 chr11:824882-824883(+) m6A 3'UTR//CDS//exon       24284625 chr11:824929-824930(+) m6A 3'UTR//CDS//exon       24284625 chr11:825112-825113(+) m6A 3'UTR//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PNPLA2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PNPLA2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.