Detail Information

Basic Information:


  VIRBase ID:  

VHID00512294

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TM9SF3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TM9SF3
miRBase
Accession/Entrez ID		 MIMAT0001581 56889
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - EP70-P-iso//SMBP

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM9SF3
chr10:98300788(-) A-I      intronic
chr10:98300785(-) A-I      intronic
chr10:98300794(-) A-I      intronic
chr10:98300793(-) A-I      intronic
chr10:98329677(-) A-I      intronic
chr10:98323987(-) A-I      intronic
chr10:98340218(-) A-I      intronic
chr10:98330623(-) A-I      intronic
chr10:98322887(-) A-I      intronic
chr10:98322956(-) A-I      intronic
chr10:98340083(-) A-I      intronic
chr10:98330768(-) A-I      intronic
chr10:98340207(-) A-I      intronic
chr10:98338622(-) A-I      intronic
chr10:98338665(-) A-I      intronic
chr10:98338671(-) A-I      intronic
chr10:98323927(-) A-I      intronic
chr10:98344403(-) A-I      intronic
chr10:98322961(-) A-I      intronic
chr10:98330751(-) A-I      intronic
chr10:98340204(-) A-I      intronic
chr10:98338715(-) A-I      intronic
chr10:98323981(-) A-I      intronic
chr10:98296651(-) A-I      intronic
chr10:98300777(-) A-I      intronic
chr10:98340290(-) A-I      intronic
chr10:98340194(-) A-I      intronic
chr10:98338751(-) A-I      intronic
chr10:98340228(-) A-I      intronic
chr10:98340226(-) A-I      intronic
chr10:98323997(-) A-I      intronic
chr10:98338788(-) A-I      intronic
chr10:98338661(-) A-I      intronic
chr10:98297494(-) A-I      intronic
chr10:98340161(-) A-I      intronic
chr10:98328826(-) A-I      intronic
chr10:98329689(-) A-I      intronic
chr10:98338676(-) A-I      intronic
chr10:98330635(-) A-I      intronic
chr10:98338777(-) A-I      intronic
chr10:98338722(-) A-I      intronic
chr10:98329626(-) A-I      intronic
chr10:98340056(-) A-I      intronic
chr10:98297506(-) A-I      intronic
chr10:98338667(-) A-I      intronic
chr10:98297473(-) A-I      intronic
chr10:98329546(-) A-I      intronic
chr10:98332390(-) A-I      intronic
chr10:98323937(-) A-I      intronic
chr10:98338653(-) A-I      intronic
chr10:98323271(-) A-I      intronic
chr10:98340187(-) A-I      intronic
chr10:98322971(-) A-I      intronic
chr10:98299011(-) A-I      intronic
chr10:98298985(-) A-I      intronic
chr10:98328845(-) A-I      intronic
chr10:98342664(-) A-I      intronic
chr10:98340287(-) A-I      intronic
chr10:98344409(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TM9SF3
chr10:98320668(-) A-I intron -    22327324
chr10:98296691(-) A-I intron -    21960545
chr10:98296716(-) A-I intron -    21960545
chr10:98322971(-) A-I intron -    21960545
chr10:98323937(-) A-I intron -    21960545
chr10:98323997(-) A-I intron -    21960545
chr10:98338621(-) A-I intron -    21960545
chr10:98338712(-) A-I intron -    21960545
chr10:98338722(-) A-I intron -    21960545
chr10:98338777(-) A-I intron -    21960545
chr10:98322971(-) A-G intron -    22484847
chr10:98340161(-) A-G intron -    22484847
chr10:98343775(-) C-T intron -    22484847
chr10:98281484(-) T-C exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM9SF3
chr10:98278050-98278051(-) m6A 3'UTR       24981863//22608085
chr10:98278075-98278076(-) m6A 3'UTR       24981863//22608085
chr10:98278106-98278107(-) m6A 3'UTR       24981863//22608085
chr10:98278149-98278150(-) m6A 3'UTR       22608085
chr10:98278157-98278158(-) m6A 3'UTR       22608085
chr10:98280601-98280602(-) m6A 3'UTR       -
chr10:98280623-98280624(-) m6A 3'UTR       -
chr10:98280646-98280647(-) m6A 3'UTR       -
chr10:98281033-98281034(-) Cm 3'UTR       -
chr10:98281112-98281113(-) m6A 3'UTR       26404942
chr10:98281319-98281320(-) m6A 3'UTR       26404942
chr10:98281367-98281368(-) m6A 3'UTR       26404942
chr10:98281394-98281395(-) m6A 3'UTR       26404942
chr10:98281529-98281530(-) m6A 3'UTR       26404942
chr10:98281659-98281660(-) m6A 3'UTR       26404942
chr10:98281708-98281709(-) m6A 3'UTR       24284625//26404942
chr10:98281731-98281732(-) m6A 3'UTR       24284625//22608085
chr10:98281755-98281756(-) m6A 3'UTR       24284625//22608085
chr10:98281951-98281952(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281966-98281967(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281999-98282000(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282006-98282007(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282016-98282017(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282066-98282067(-) m6A CDS//exon       24284625//24981863//26404942//27371828//22608085
chr10:98321836-98321837(-) m6A CDS//exon       26404942
chr10:98321847-98321848(-) m6A CDS//exon       26404942
chr10:98336381-98336382(-) m6A exon//intron       26404942
chr10:98336453-98336454(-) m6A CDS//exon       26404942//27773535
chr10:98336519-98336520(-) m6A CDS//exon       24209618//26404942//27773535
chr10:98337276-98337277(-) m6A exon//intron       24209618
chr10:98346496-98346497(-) m6A CDS//exon//intron       24209618//27371828//27773536
chr10:98346516-98346517(-) m6A CDS//intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TM9SF3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TM9SF3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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