Basic Information:

  VIRBase ID:  

VHID00512263

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TRIM39:  NM_021253     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TRIM39
miRBase Accession/Entrez ID	MIMAT0001581	56658
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	RNF23//TFP//TRIM39B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRIM39	chr6:30305071(+) A-I      intronic chr6:30303244(+) A-I      intronic chr6:30303343(+) A-I      intronic chr6:30307055(+) A-I      intronic chr6:30303140(+) A-I      intronic chr6:30302586(+) A-I      intronic chr6:30302640(+) A-I      intronic chr6:30304994(+) A-I      intronic chr6:30307200(+) A-I      intronic chr6:30298925(+) A-I      intronic chr6:30306948(+) A-I      intronic chr6:30305224(+) A-I      intronic chr6:30306982(+) A-I      intronic chr6:30305208(+) A-I      intronic chr6:30303128(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIM39	chr6:30294369-30294370(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:30294374-30294375(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:30294594-30294595(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536 chr6:30294756-30294757(+) m6A 5'UTR//intron       27773536 chr6:30295092-30295093(+) m6A 5'UTR//intron       25456834//24981863//27773536//22608085 chr6:30295194-30295195(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr6:30295206-30295207(+) m6A 5'UTR//intron       25456834//22608085 chr6:30295237-30295238(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr6:30295244-30295245(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr6:30295256-30295257(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr6:30295296-30295297(+) m6A 5'UTR//intron       25456834//22608085 chr6:30295322-30295323(+) m6A 5'UTR//intron       25456834//22608085 chr6:30297103-30297104(+) m6A CDS       - chr6:30297158-30297159(+) m6A CDS       - chr6:30297207-30297208(+) m6A CDS       24284625 chr6:30297269-30297270(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:30297281-30297282(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:30297307-30297308(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:30298562-30298563(+) m6A CDS       - chr6:30298589-30298590(+) m6A CDS       - chr6:30303523-30303524(+) m6A CDS       - chr6:30303628-30303629(+) m6A CDS       24981863 chr6:30303633-30303634(+) m6A CDS       24981863 chr6:30303675-30303676(+) m6A CDS       24981863 chr6:30309568-30309569(+) m6A CDS       24284625 chr6:30309573-30309574(+) m6A CDS       24284625 chr6:30309685-30309686(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309713-30309714(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309754-30309755(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309788-30309789(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309840-30309841(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309866-30309867(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309905-30309906(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:30309948-30309949(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr6:30310156-30310157(+) m6A 3'UTR       25456834 chr6:30310200-30310201(+) m6A 3'UTR       - chr6:30310736-30310737(+) m6A 3'UTR       27773535 chr6:30311397-30311398(+) m6A 3'UTR       24981863//22608085 chr6:30311408-30311409(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIM39	Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIM39

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.