Basic Information:

  VIRBase ID:  

VHID00512210

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          FAM214A:  NM_001385015     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	FAM214A
miRBase Accession/Entrez ID	MIMAT0001581	56204
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1370

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM214A	chr15:52904905(-) A-I      intronic chr15:52904921(-) A-I      intronic chr15:52904875(-) A-I      intronic chr15:52904881(-) A-I      intronic chr15:52904878(-) A-I      intronic chr15:52885230(-) A-I      intronic chr15:52885218(-) A-I      intronic chr15:52926367(-) A-I      intronic chr15:52890158(-) A-I      intronic chr15:52910960(-) A-I      intronic chr15:52912006(-) A-I      intronic chr15:52935713(-) A-I      intronic chr15:52911845(-) A-I      intronic chr15:52904383(-) A-I      intronic chr15:52904424(-) A-I      intronic chr15:52932571(-) A-I      intronic chr15:52961312(-) A-I      intronic chr15:52904756(-) A-I      intronic chr15:52904787(-) A-I      intronic chr15:52927655(-) A-I      intronic chr15:52961352(-) A-I      intronic chr15:52924194(-) A-I      intronic chr15:52904871(-) A-I      intronic chr15:52961307(-) A-I      intronic chr15:52904895(-) A-I      intronic chr15:52904903(-) A-I      intronic chr15:52961347(-) A-I      intronic chr15:52904929(-) A-I      intronic chr15:52927078(-) A-I      intronic chr15:52950959(-) A-I      intronic chr15:52937453(-) A-I      intronic chr15:52937560(-) A-I      intronic chr15:52935092(-) A-I      intronic chr15:52905441(-) A-I      intronic chr15:52905494(-) A-I      intronic chr15:52905516(-) A-I      intronic chr15:52932656(-) A-I      intronic chr15:52888259(-) A-I      intronic chr15:52926408(-) A-I      intronic chr15:52917249(-) A-I      intronic chr15:52906497(-) A-I      intronic chr15:52926907(-) A-I      intronic chr15:52956022(-) A-I      intronic chr15:52926963(-) A-I      intronic chr15:52932536(-) A-I      intronic chr15:52906928(-) A-I      intronic chr15:52882152(-) A-I      intronic chr15:52908746(-) A-I      intronic chr15:52908759(-) A-I      intronic chr15:52926520(-) A-I      intronic chr15:52961279(-) A-I      intronic chr15:52961391(-) A-I      intronic chr15:52961374(-) A-I      intronic chr15:52926413(-) A-I      intronic chr15:52961199(-) A-I      intronic chr15:52932161(-) A-I      intronic chr15:52904839(-) A-I      intronic chr15:52905447(-) A-I      intronic chr15:52961163(-) A-I      intronic chr15:52927022(-) A-I      intronic chr15:52910312(-) A-I      intronic chr15:52880774(-) A-I      intronic chr15:52957083(-) A-I      intronic chr15:52957052(-) A-I      intronic chr15:52957013(-) A-I      intronic chr15:52910344(-) A-I      intronic chr15:52890155(-) A-I      intronic chr15:52961252(-) A-I      intronic chr15:52956073(-) A-I      intronic chr15:52955939(-) A-I      intronic chr15:52954818(-) A-I      intronic chr15:52954800(-) A-I      intronic chr15:52953102(-) A-I      intronic chr15:52955957(-) A-I      intronic chr15:52910347(-) A-I      intronic chr15:52904955(-) A-I      intronic chr15:52932160(-) A-I      intronic chr15:52910360(-) A-I      intronic chr15:52950989(-) A-I      intronic chr15:52932115(-) A-I      intronic chr15:52937511(-) A-I      intronic chr15:52882186(-) A-I      intronic chr15:52937508(-) A-I      intronic chr15:52910374(-) A-I      intronic chr15:52883655(-) A-I      intronic chr15:52937444(-) A-I      intronic chr15:52936394(-) A-I      intronic chr15:52936320(-) A-I      intronic chr15:52957053(-) A-I      intronic chr15:52961355(-) A-I      intronic chr15:52953124(-) A-I      intronic chr15:52905559(-) A-I      intronic chr15:52936001(-) A-I      intronic chr15:52885178(-) A-I      intronic chr15:52905561(-) A-I      intronic chr15:52910384(-) A-I      intronic chr15:52880703(-) A-I      intronic chr15:52927049(-) A-I      intronic chr15:52932104(-) A-I      intronic chr15:52904834(-) A-I      intronic chr15:52932086(-) A-I      intronic chr15:52885260(-) A-I      intronic chr15:52961175(-) A-I      intronic chr15:52953123(-) A-I      intronic chr15:52961294(-) A-I      intronic chr15:52935999(-) A-I      intronic chr15:52932641(-) A-I      intronic chr15:52932076(-) A-I      intronic chr15:52882123(-) A-I      intronic chr15:52961243(-) A-I      intronic chr15:52930674(-) A-I      intronic chr15:52937536(-) A-I      intronic chr15:52927861(-) A-I      intronic chr15:52905477(-) A-I      intronic chr15:52905378(-) A-I      intronic chr15:52935097(-) A-I      intronic chr15:52926479(-) A-I      intronic chr15:52927672(-) A-I      intronic chr15:52904364(-) A-I      intronic chr15:52935998(-) A-I      intronic chr15:52935137(-) A-I      intronic chr15:52926385(-) A-I      intronic chr15:52904937(-) A-I      intronic chr15:52927887(-) A-I      intronic chr15:52935613(-) A-I      intronic chr15:52882053(-) A-I      intronic chr15:52885234(-) A-I      intronic chr15:52882025(-) A-I      intronic chr15:52882090(-) A-I      intronic chr15:52882106(-) A-I      intronic chr15:52885101(-) A-I      intronic chr15:52885123(-) A-I      intronic chr15:52885232(-) A-I      intronic chr15:52906498(-) A-I      intronic chr15:52882264(-) A-I      intronic chr15:52926488(-) A-I      intronic chr15:52932175(-) A-I      intronic chr15:52914171(-) A-I      intronic chr15:52882156(-) A-I      intronic chr15:52926978(-) A-I      intronic chr15:52885233(-) A-I      intronic chr15:52935644(-) A-I      intronic chr15:52883630(-) A-I      intronic chr15:52885193(-) A-I      intronic chr15:52937373(-) A-I      intronic chr15:52904934(-) A-I      intronic chr15:52885088(-) A-I      intronic chr15:52885310(-) A-I      intronic chr15:52882167(-) A-I      intronic chr15:52888195(-) A-I      intronic chr15:52954314(-) A-I      intronic chr15:52935759(-) A-I      intronic chr15:52961238(-) A-I      intronic chr15:52957011(-) A-I      intronic chr15:52883599(-) A-I      intronic chr15:52880800(-) A-I      intronic chr15:52904973(-) A-I      intronic chr15:52927846(-) A-I      intronic chr15:52883600(-) A-I      intronic chr15:52929337(-) A-I      intronic chr15:52924137(-) A-I      intronic chr15:52929638(-) A-I      intronic chr15:52935116(-) A-I      intronic chr15:52932583(-) A-I      intronic chr15:52885126(-) A-I      intronic chr15:52885100(-) A-I      intronic chr15:52967993(-) A-I      intronic chr15:52932691(-) A-I      intronic chr15:52885194(-) A-I      intronic chr15:52951059(-) A-I      intronic chr15:52929345(-) A-I      intronic chr15:52929737(-) A-I      intronic chr15:52932600(-) A-I      intronic chr15:52876607(-) A-I      intronic chr15:52930789(-) A-I      intronic chr15:52882162(-) A-I      intronic chr15:52961253(-) A-I      intronic chr15:52936108(-) A-I      intronic chr15:52935685(-) A-I      intronic chr15:52883551(-) A-I      intronic chr15:52935908(-) A-I      intronic chr15:52926579(-) A-I      intronic chr15:52910396(-) A-I      intronic chr15:52935775(-) A-I      intronic chr15:52880813(-) A-I      intronic chr15:52906963(-) A-I      intronic chr15:52932692(-) A-I      intronic chr15:52932724(-) A-I      intronic chr15:52910954(-) A-I      intronic chr15:52956886(-) A-I      intronic chr15:52883592(-) A-I      intronic chr15:52885259(-) A-I      intronic chr15:52935621(-) A-I      intronic chr15:52905321(-) A-I      intronic chr15:52910439(-) A-I      intronic chr15:52957048(-) A-I      intronic chr15:52926931(-) A-I      intronic chr15:52955981(-) A-I      intronic chr15:52885082(-) A-I      intronic chr15:52906499(-) A-I      intronic chr15:52885274(-) A-I      intronic chr15:52932730(-) A-I      intronic chr15:52885187(-) A-I      intronic chr15:52957049(-) A-I      intronic chr15:52961263(-) A-I      intronic chr15:52936102(-) A-I      intronic chr15:52950903(-) A-I      intronic chr15:52967983(-) A-I      intronic chr15:52951146(-) A-I      intronic chr15:52932152(-) A-I      intronic chr15:52917213(-) A-I      intronic chr15:52911921(-) A-I      intronic chr15:52883637(-) A-I      intronic chr15:52932040(-) A-I      intronic chr15:52882149(-) A-I      intronic chr15:52885261(-) A-I      intronic chr15:52917203(-) A-I      intronic chr15:52927087(-) A-I      intronic chr15:52883576(-) A-I      intronic chr15:52931976(-) A-I      intronic chr15:52885152(-) A-I      intronic chr15:52937379(-) A-I      intronic chr15:52906435(-) A-I      intronic chr15:52955984(-) A-I      intronic chr15:52926937(-) A-I      intronic chr15:52935859(-) A-I      intronic chr15:52882155(-) A-I      intronic chr15:52906962(-) A-I      intronic chr15:52926465(-) A-I      intronic chr15:52885214(-) A-I      intronic chr15:52950944(-) A-I      intronic chr15:52911976(-) A-I      intronic chr15:52935038(-) A-I      intronic chr15:52906933(-) A-I      intronic chr15:52936027(-) A-I      intronic chr15:52882217(-) A-I      intronic chr15:52906431(-) A-I      intronic chr15:52932716(-) A-I      intronic chr15:52882052(-) A-I      intronic chr15:52883566(-) A-I      intronic chr15:52935107(-) A-I      intronic chr15:52905451(-) A-I      intronic chr15:52957128(-) A-I      intronic chr15:52955955(-) A-I      intronic chr15:52935617(-) A-I      intronic chr15:52926981(-) A-I      intronic chr15:52910944(-) A-I      intronic chr15:52932639(-) A-I      intronic chr15:52932054(-) A-I      intronic chr15:52904972(-) A-I      intronic chr15:52885220(-) A-I      intronic chr15:52935078(-) A-I      intronic chr15:52885291(-) A-I      intronic chr15:52885309(-) A-I      intronic chr15:52905420(-) A-I      intronic chr15:52914315(-) A-I      intronic chr15:52883725(-) A-I      intronic chr15:52910950(-) A-I      intronic chr15:52885114(-) A-I      intronic chr15:52935705(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM214A	chr15:52883576(-) A-I intron -    21960545   //22327324 chr15:52883637(-) A-I intron -    22327324 chr15:52885159(-) A-I intron -    21960545   //22327324 chr15:52885187(-) A-I intron -    21960545   //22327324 chr15:52885259(-) A-I intron -    22327324 chr15:52885309(-) A-I intron -    21960545   //22327324 chr15:52929638(-) A-I intron -    21960545   //22327324 chr15:52961163(-) A-I intron -    22028664 chr15:52961175(-) A-I intron -    22028664 chr15:52961243(-) A-I intron -    22028664 chr15:52961252(-) A-I intron -    22028664 chr15:52961263(-) A-I intron -    22028664 chr15:52961279(-) A-I intron -    22028664 chr15:52961294(-) A-I intron -    22028664 chr15:52961307(-) A-I intron -    22028664 chr15:52961312(-) A-I intron -    22028664 chr15:52961347(-) A-I intron -    22028664 chr15:52961352(-) A-I intron -    22028664 chr15:52961355(-) A-I intron -    22028664 chr15:52883725(-) A-I intron -    21960545 chr15:52885152(-) A-I intron -    21960545 chr15:52882052(-) A-I intron -    21960545 chr15:52882217(-) A-I intron -    21960545 chr15:52885100(-) A-I intron -    21960545 chr15:52885220(-) A-I intron -    21960545 chr15:52885291(-) A-I intron -    21960545 chr15:52885310(-) A-I intron -    21960545 chr15:52906273(-) A-I intron -    21960545 chr15:52910997(-) A-I intron -    21960545 chr15:52914143(-) A-I intron -    21960545 chr15:52914171(-) A-I intron -    21960545 chr15:52914208(-) A-I intron -    21960545 chr15:52926520(-) A-I intron -    21960545 chr15:52929269(-) A-I intron -    21960545 chr15:52929337(-) A-I intron -    21960545 chr15:52929345(-) A-I intron -    21960545 chr15:52929637(-) A-I intron -    21960545 chr15:52935107(-) A-I intron -    21960545 chr15:52955920(-) A-I intron -    21960545 chr15:52955981(-) A-I intron -    21960545 chr15:52955984(-) A-I intron -    21960545 chr15:52956065(-) A-I intron -    21960545 chr15:52956073(-) A-I intron -    21960545 chr15:52957011(-) A-I intron -    21960545 chr15:52957013(-) A-I intron -    21960545 chr15:52965425(-) A-I intron -    21960545 chr15:52965776(-) A-I intron -    21960545 chr15:52965789(-) A-I intron -    21960545 chr15:52882052(-) A-G intron -    22484847 chr15:52882162(-) A-G intron -    22484847 chr15:52882167(-) A-G intron -    22484847 chr15:52882264(-) A-G intron -    22484847 chr15:52883576(-) A-G intron -    22484847 chr15:52883592(-) A-G intron -    22484847 chr15:52883599(-) A-G intron -    22484847 chr15:52883630(-) A-G intron -    22484847 chr15:52883637(-) A-G intron -    22484847 chr15:52885152(-) A-G intron -    22484847 chr15:52885187(-) A-G intron -    22484847 chr15:52885193(-) A-G intron -    22484847 chr15:52885220(-) A-G intron -    22484847 chr15:52885234(-) A-G intron -    22484847 chr15:52885259(-) A-G intron -    22484847 chr15:52885291(-) A-G intron -    22484847 chr15:52885309(-) A-G intron -    22484847 chr15:52935775(-) A-G intron -    22484847 chr15:52937379(-) A-G intron -    22484847 chr15:52961263(-) A-G intron -    22484847 chr15:52961279(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM214A	chr15:52873738-52873739(-) m6A 3'UTR//exon       27773535 chr15:52897382-52897383(-) m6A CDS//exon       27773535 chr15:52897407-52897408(-) m6A CDS//exon       24981863//27773535 chr15:52897428-52897429(-) m6A CDS//exon       24981863//27773535 chr15:52897439-52897440(-) m6A CDS//exon       24981863//27773535 chr15:52900807-52900808(-) m6A CDS       24981863//27773535//22608085 chr15:52900834-52900835(-) m6A CDS       24981863//27773535//22608085 chr15:52900875-52900876(-) m6A CDS       24981863//27773535//22608085 chr15:52900891-52900892(-) m6A CDS       24981863//27773535//22608085 chr15:52900973-52900974(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52900990-52900991(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901020-52901021(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901119-52901120(-) m6A CDS       24981863//27773535//22608085 chr15:52901163-52901164(-) m6A CDS       24981863//27773535//22608085 chr15:52901193-52901194(-) m6A CDS       24981863//27773535//22608085 chr15:52901302-52901303(-) m6A CDS       24981863//27773535//22608085 chr15:52901309-52901310(-) m6A CDS       24981863//27773535//22608085 chr15:52901347-52901348(-) m6A CDS       24981863//27773535//22608085 chr15:52901366-52901367(-) m6A CDS       24981863//27773535//22608085 chr15:52901373-52901374(-) m6A CDS       24981863//27773535//22608085 chr15:52901437-52901438(-) m6A CDS       27773535 chr15:52901455-52901456(-) m6A CDS       27773535 chr15:52901530-52901531(-) m6A CDS       27773535 chr15:52901699-52901700(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901744-52901745(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901759-52901760(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901766-52901767(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901794-52901795(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52901889-52901890(-) m6A CDS       24981863//27773535//22608085 chr15:52902035-52902036(-) m6A CDS       27773535//22608085 chr15:52902107-52902108(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902119-52902120(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902176-52902177(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902213-52902214(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902290-52902291(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902300-52902301(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902325-52902326(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902339-52902340(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902371-52902372(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902378-52902379(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:52902456-52902457(-) m6A CDS       24981863 chr15:52970207-52970208(-) m6A 5'UTR//CDS       - chr15:52970265-52970266(-) m6A 5'UTR       - chr15:52970883-52970884(-) m6A 5'UTR//intron       25456834 chr15:52970914-52970915(-) m6A 5'UTR//intron       25456834 chr15:52970942-52970943(-) m6A 5'UTR//intron       24284625//25456834//24981863 chr15:52971062-52971063(-) m6A 5'UTR//intron       24284625//25456834//24981863 chr15:52971506-52971507(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr15:52971552-52971553(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr15:52971566-52971567(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr15:53001935-53001936(-) m6A 5'UTR       25456834//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM214A	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: FAM214A

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.