Basic Information:

  VIRBase ID:  

VHID00512148

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          UBFD1:  NM_019116     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	UBFD1
miRBase Accession/Entrez ID	MIMAT0001581	56061
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	UBPH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBFD1	chr16:23579622(+) A-I      intronic chr16:23579646(+) A-I      intronic chr16:23580833(+) A-I      intronic chr16:23579987(+) A-I      intronic chr16:23579939(+) A-I      intronic chr16:23579922(+) A-I      intronic chr16:23579895(+) A-I      intronic chr16:23579678(+) A-I      intronic chr16:23579666(+) A-I      intronic chr16:23579661(+) A-I      intronic chr16:23579655(+) A-I      intronic chr16:23579638(+) A-I      intronic chr16:23579574(+) A-I      intronic chr16:23580033(+) A-I      intronic chr16:23579993(+) A-I      intronic chr16:23579691(+) A-I      intronic chr16:23579963(+) A-I      intronic chr16:23579681(+) A-I      intronic chr16:23579610(+) A-I      intronic chr16:23579988(+) A-I      intronic chr16:23577905(+) A-I      intronic chr16:23579887(+) A-I      intronic chr16:23580729(+) A-I      intronic chr16:23579633(+) A-I      intronic chr16:23577917(+) A-I      intronic chr16:23577799(+) A-I      intronic chr16:23577847(+) A-I      intronic chr16:23580689(+) A-I      intronic chr16:23579864(+) A-I      intronic chr16:23579979(+) A-I      intronic chr16:23580020(+) A-I      intronic chr16:23579740(+) A-I      intronic chr16:23579753(+) A-I      intronic chr16:23580737(+) A-I      intronic chr16:23579620(+) A-I      intronic chr16:23579545(+) A-I      intronic chr16:23579984(+) A-I      intronic chr16:23580673(+) A-I      intronic chr16:23580777(+) A-I      intronic chr16:23580029(+) A-I      intronic chr16:23580603(+) A-I      intronic chr16:23579555(+) A-I      intronic chr16:23579953(+) A-I      intronic chr16:23580069(+) A-I      intronic chr16:23580755(+) A-I      intronic chr16:23579741(+) A-I      intronic chr16:23577961(+) A-I      intronic chr16:23579892(+) A-I      intronic chr16:23580070(+) A-I      intronic chr16:23580765(+) A-I      intronic chr16:23580082(+) A-I      intronic chr16:23579975(+) A-I      intronic chr16:23580699(+) A-I      intronic chr16:23579954(+) A-I      intronic chr16:23579978(+) A-I      intronic chr16:23580025(+) A-I      intronic chr16:23579981(+) A-I      intronic chr16:23580826(+) A-I      intronic chr16:23579980(+) A-I      intronic chr16:23580019(+) A-I      intronic chr16:23580112(+) A-I      intronic chr16:23579664(+) A-I      intronic chr16:23580756(+) A-I      intronic chr16:23579886(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBFD1	chr16:23580019(+) A-I intron -    15342557 chr16:23580020(+) A-I intron -    15342557 chr16:23580025(+) A-I intron -    15342557 chr16:23580112(+) A-I intron -    15342557 chr16:23580603(+) A-I intron -    15342557 chr16:23580756(+) A-I intron -    15342557 chr16:23580777(+) A-I intron -    15342557 chr16:23570696(+) C-A intron -    22484847 chr16:23579610(+) A-G intron -    22484847 chr16:23579930(+) A-G intron -    22484847 chr16:23579954(+) A-G intron -    22484847 chr16:23579978(+) A-G intron -    22484847 chr16:23579980(+) A-G intron -    22484847 chr16:23580019(+) A-G intron -    22484847 chr16:23580020(+) A-G intron -    22484847 chr16:23580025(+) A-G intron -    22484847 chr16:23580112(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBFD1	chr16:23568712-23568713(+) m6A 5'UTR       24981863 chr16:23568910-23568911(+) m6A 5'UTR       24981863 chr16:23568943-23568944(+) m6A 5'UTR       24981863 chr16:23569175-23569176(+) m6A exon//intron       24981863 chr16:23569211-23569212(+) m6A exon//intron       24209618//25456834//24981863 chr16:23569280-23569281(+) m6A CDS//exon       24209618//25456834//24981863 chr16:23569291-23569292(+) m6A CDS//exon       24209618//25456834//24981863 chr16:23569305-23569306(+) m6A CDS//exon       24209618//25456834//24981863//22575960 chr16:23569381-23569382(+) m6A CDS//exon       24209618//24981863//22575960 chr16:23569435-23569436(+) m6A CDS//exon       24209618//27773536//22575960 chr16:23569504-23569505(+) m6A CDS//exon       24209618 chr16:23569527-23569528(+) m6A CDS//exon       24209618 chr16:23569555-23569556(+) m6A CDS//exon       24209618 chr16:23569577-23569578(+) m6A CDS//exon       24209618 chr16:23570923-23570924(+) m6A CDS//exon       24981863 chr16:23570968-23570969(+) m6A CDS//exon       24981863 chr16:23578356-23578357(+) m6A CDS//exon       24284625 chr16:23578368-23578369(+) m6A CDS//exon       24284625 chr16:23578376-23578377(+) m6A CDS//exon       24284625//24981863 chr16:23581879-23581880(+) m6A CDS//exon       24284625//24981863//22608085 chr16:23581937-23581938(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr16:23581955-23581956(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr16:23582003-23582004(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22608085 chr16:23584662-23584663(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBFD1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: UBFD1

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	cRep//miRanda
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.