Basic Information:

  VIRBase ID:  

VHID00512078

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZC3H15:  NM_018471     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZC3H15
miRBase Accession/Entrez ID	MIMAT0001581	55854
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HT010//LEREPO4//MSTP012

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZC3H15	chr2:187371544(+) A-I      Syn:Thr->Thr chr2:187366713(+) A-I      intronic chr2:187366565(+) A-I      intronic chr2:187366525(+) A-I      intronic chr2:187371248(+) A-I      intronic chr2:187366820(+) A-I      intronic chr2:187366847(+) A-I      intronic chr2:187366925(+) A-I      intronic chr2:187371240(+) A-I      intronic chr2:187367040(+) A-I      intronic chr2:187366639(+) A-I      intronic chr2:187366895(+) A-I      intronic chr2:187366818(+) A-I      intronic chr2:187366868(+) A-I      intronic chr2:187366922(+) A-I      intronic chr2:187367062(+) A-I      intronic chr2:187367043(+) A-I      intronic chr2:187366463(+) A-I      intronic chr2:187366924(+) A-I      intronic chr2:187366622(+) A-I      intronic chr2:187366912(+) A-I      intronic chr2:187366600(+) A-I      intronic chr2:187366508(+) A-I      intronic chr2:187366935(+) A-I      intronic chr2:187366919(+) A-I      intronic chr2:187366538(+) A-I      intronic chr2:187366957(+) A-I      intronic chr2:187366959(+) A-I      intronic chr2:187366928(+) A-I      intronic chr2:187366699(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZC3H15	chr2:187366895(+) A-I intron -    22327324 chr2:187367043(+) A-I intron -    22327324 chr2:187366503(+) A-G intron -    22484847 chr2:187366508(+) A-G intron -    22484847 chr2:187366538(+) A-G intron -    22484847 chr2:187366556(+) A-G intron -    22484847 chr2:187366818(+) A-G intron -    22484847 chr2:187366876(+) A-G intron -    22484847 chr2:187366895(+) A-G intron -    22484847 chr2:187366896(+) A-G intron -    22484847 chr2:187366922(+) A-G intron -    22484847 chr2:187366928(+) A-G intron -    22484847 chr2:187366979(+) A-G intron -    22484847 chr2:187367043(+) A-G intron -    22484847 chr2:187367054(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZC3H15	chr2:187351054-187351055(+) m6A 5'UTR//exon       24981863 chr2:187351123-187351124(+) m6A CDS//exon       24981863//27773535 chr2:187351641-187351642(+) m6A exon//intron       24981863//27773535 chr2:187351714-187351715(+) m6A exon//intron       24981863//27773535 chr2:187352042-187352043(+) m6A exon//intron       24981863 chr2:187352063-187352064(+) m6A exon//intron       24981863 chr2:187352076-187352077(+) m6A exon//intron       24981863 chr2:187359960-187359961(+) m6A CDS//exon       24981863//22575960 chr2:187359965-187359966(+) m6A CDS//exon       24981863//22575960 chr2:187364988-187364989(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr2:187366042-187366043(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22575960 chr2:187366141-187366142(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr2:187367267-187367268(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr2:187367298-187367299(+) m6A CDS//intron       24981863//27773535//22575960 chr2:187367305-187367306(+) m6A CDS//intron       24981863//27773535//22575960 chr2:187368789-187368790(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr2:187369839-187369840(+) m6A exon//intron       24981863//27773535 chr2:187369850-187369851(+) m6A exon//intron       24981863//27773535 chr2:187370248-187370249(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr2:187370266-187370267(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr2:187370272-187370273(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr2:187370501-187370502(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr2:187370553-187370554(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr2:187370614-187370615(+) m6A 3'UTR//intron       24981863//27773535 chr2:187370812-187370813(+) m6A 3'UTR//intron       24981863//27773535 chr2:187371505-187371506(+) m6A CDS//exon       24981863//27773535 chr2:187372128-187372129(+) m6A CDS//intron       24981863//27773535 chr2:187372164-187372165(+) m6A CDS//intron       24981863//27773535 chr2:187373272-187373273(+) m6A CDS//exon       24981863//27773535//22608085 chr2:187373335-187373336(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr2:187373420-187373421(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22608085 chr2:187373466-187373467(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr2:187373787-187373788(+) m6A 3'UTR       26404942//27773535 chr2:187373794-187373795(+) m6A 3'UTR       26404942//27773535 chr2:187373873-187373874(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr2:187373883-187373884(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr2:187373910-187373911(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr2:187373945-187373946(+) m6A 3'UTR       24981863//27773535//22608085 chr2:187373957-187373958(+) m6A 3'UTR       24981863//27773535//22608085 chr2:187373971-187373972(+) m6A 3'UTR       24981863//27773535//22608085 chr2:187374065-187374066(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZC3H15	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZC3H15

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.