Basic Information:

  VIRBase ID:  

VHID00512049

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          UTP6:  NM_018428     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	UTP6
miRBase Accession/Entrez ID	MIMAT0001581	55813
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C17orf40//HCA66

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UTP6	chr17:30203275(-) A-I      intronic chr17:30203110(-) A-I      intronic chr17:30203249(-) A-I      intronic chr17:30203088(-) A-I      intronic chr17:30203090(-) A-I      intronic chr17:30189823(-) A-I      3'UTR chr17:30203139(-) A-I      intronic chr17:30203272(-) A-I      intronic chr17:30227051(-) A-I      intronic chr17:30190897(-) A-I      intronic chr17:30190824(-) A-I      intronic chr17:30199595(-) A-I      intronic chr17:30212744(-) A-I      intronic chr17:30216223(-) A-I      intronic chr17:30216224(-) A-I      intronic chr17:30216635(-) A-I      intronic chr17:30216720(-) A-I      intronic chr17:30217069(-) A-I      intronic chr17:30217257(-) A-I      intronic chr17:30217287(-) A-I      intronic chr17:30217288(-) A-I      intronic chr17:30217290(-) A-I      intronic chr17:30217770(-) A-I      intronic chr17:30218918(-) A-I      intronic chr17:30220718(-) A-I      intronic chr17:30224263(-) A-I      intronic chr17:30224579(-) A-I      intronic chr17:30224591(-) A-I      intronic chr17:30224599(-) A-I      intronic chr17:30224649(-) A-I      intronic chr17:30224724(-) A-I      intronic chr17:30225374(-) A-I      intronic chr17:30225461(-) A-I      intronic chr17:30225634(-) A-I      intronic chr17:30227081(-) A-I      intronic chr17:30199761(-) A-I      intronic chr17:30199776(-) A-I      intronic chr17:30199892(-) A-I      intronic chr17:30202694(-) A-I      intronic chr17:30202698(-) A-I      intronic chr17:30202718(-) A-I      intronic chr17:30203100(-) A-I      intronic chr17:30203223(-) A-I      intronic chr17:30203250(-) A-I      intronic chr17:30203576(-) A-I      intronic chr17:30203551(-) A-I      intronic chr17:30203535(-) A-I      intronic chr17:30203528(-) A-I      intronic chr17:30203501(-) A-I      intronic chr17:30203492(-) A-I      intronic chr17:30203337(-) A-I      intronic chr17:30203320(-) A-I      intronic chr17:30212725(-) A-I      intronic chr17:30198125(-) A-I      intronic chr17:30203269(-) A-I      intronic chr17:30212724(-) A-I      intronic chr17:30212627(-) A-I      intronic chr17:30212357(-) A-I      intronic chr17:30212352(-) A-I      intronic chr17:30212343(-) A-I      intronic chr17:30212340(-) A-I      intronic chr17:30212339(-) A-I      intronic chr17:30212337(-) A-I      intronic chr17:30218816(-) A-I      intronic chr17:30212328(-) A-I      intronic chr17:30209227(-) A-I      intronic chr17:30209155(-) A-I      intronic chr17:30204005(-) A-I      intronic chr17:30203974(-) A-I      intronic chr17:30203936(-) A-I      intronic chr17:30203922(-) A-I      intronic chr17:30203862(-) A-I      intronic chr17:30203786(-) A-I      intronic chr17:30203637(-) A-I      intronic chr17:30203624(-) A-I      intronic chr17:30203600(-) A-I      intronic chr17:30203581(-) A-I      intronic chr17:30203577(-) A-I      intronic chr17:30199058(-) A-I      intronic chr17:30198848(-) A-I      intronic chr17:30198670(-) A-I      intronic chr17:30198669(-) A-I      intronic chr17:30198283(-) A-I      intronic chr17:30198278(-) A-I      intronic chr17:30198216(-) A-I      intronic chr17:30198211(-) A-I      intronic chr17:30198181(-) A-I      intronic chr17:30198180(-) A-I      intronic chr17:30198157(-) A-I      intronic chr17:30198137(-) A-I      intronic chr17:30196642(-) A-I      intronic chr17:30196636(-) A-I      intronic chr17:30196596(-) A-I      intronic chr17:30196349(-) A-I      intronic chr17:30196047(-) A-I      intronic chr17:30196018(-) A-I      intronic chr17:30195645(-) A-I      intronic chr17:30195557(-) A-I      intronic chr17:30195465(-) A-I      intronic chr17:30195460(-) A-I      intronic chr17:30191400(-) A-I      intronic chr17:30191392(-) A-I      intronic chr17:30190938(-) A-I      intronic chr17:30190936(-) A-I      intronic chr17:30190902(-) A-I      intronic chr17:30188388(-) A-I      3'UTR chr17:30188500(-) A-I      3'UTR chr17:30188523(-) A-I      3'UTR chr17:30188535(-) A-I      3'UTR chr17:30189178(-) A-I      3'UTR chr17:30189773(-) A-I      3'UTR chr17:30189784(-) A-I      3'UTR chr17:30189785(-) A-I      3'UTR chr17:30189792(-) A-I      3'UTR chr17:30189794(-) A-I      3'UTR chr17:30189807(-) A-I      3'UTR chr17:30188584(-) A-I      3'UTR chr17:30188176(-) A-I      3'UTR chr17:30217131(-) A-I      intronic chr17:30218930(-) A-I      intronic chr17:30198085(-) A-I      intronic chr17:30198368(-) A-I      intronic chr17:30190833(-) A-I      intronic chr17:30203145(-) A-I      intronic chr17:30203128(-) A-I      intronic chr17:30217585(-) A-I      intronic chr17:30203153(-) A-I      intronic chr17:30196506(-) A-I      intronic chr17:30203563(-) A-I      intronic chr17:30226204(-) A-I      intronic chr17:30224604(-) A-I      intronic chr17:30202693(-) A-I      intronic chr17:30217537(-) A-I      intronic chr17:30201788(-) A-I      intronic chr17:30203244(-) A-I      intronic chr17:30195555(-) A-I      intronic chr17:30204023(-) A-I      intronic chr17:30202720(-) A-I      intronic chr17:30223241(-) A-I      intronic chr17:30190893(-) A-I      intronic chr17:30203235(-) A-I      intronic chr17:30208067(-) A-I      intronic chr17:30196054(-) A-I      intronic chr17:30202679(-) A-I      intronic chr17:30199066(-) A-I      intronic chr17:30200272(-) A-I      intronic chr17:30203419(-) A-I      intronic chr17:30217843(-) A-I      intronic chr17:30203839(-) A-I      intronic chr17:30203420(-) A-I      intronic chr17:30190795(-) A-I      intronic chr17:30217923(-) A-I      intronic chr17:30195549(-) A-I      intronic chr17:30212346(-) A-I      intronic chr17:30196285(-) A-I      intronic chr17:30209541(-) A-I      intronic chr17:30225423(-) A-I      intronic chr17:30202676(-) A-I      intronic chr17:30217897(-) A-I      intronic chr17:30193694(-) A-I      intronic chr17:30217894(-) A-I      intronic chr17:30227565(-) A-I      intronic chr17:30222928(-) A-I      intronic chr17:30217906(-) A-I      intronic chr17:30212436(-) A-I      intronic chr17:30224605(-) A-I      intronic chr17:30196580(-) A-I      intronic chr17:30192172(-) A-I      intronic chr17:30201779(-) A-I      intronic chr17:30224229(-) A-I      intronic chr17:30203452(-) A-I      intronic chr17:30191324(-) A-I      intronic chr17:30222661(-) A-I      intronic chr17:30208851(-) A-I      intronic chr17:30190919(-) A-I      intronic chr17:30189165(-) A-I      3'UTR chr17:30203788(-) A-I      intronic chr17:30196664(-) A-I      intronic chr17:30203081(-) A-I      intronic chr17:30189150(-) A-I      3'UTR chr17:30203538(-) A-I      intronic chr17:30200161(-) A-I      intronic chr17:30217282(-) A-I      intronic chr17:30225299(-) A-I      intronic chr17:30202790(-) A-I      intronic chr17:30189656(-) A-I      3'UTR chr17:30195464(-) A-I      intronic chr17:30217144(-) A-I      intronic chr17:30203152(-) A-I      intronic chr17:30220105(-) A-I      intronic chr17:30196628(-) A-I      intronic chr17:30212341(-) A-I      intronic chr17:30222922(-) A-I      intronic chr17:30203891(-) A-I      intronic chr17:30226510(-) A-I      intronic chr17:30218798(-) A-I      intronic chr17:30200087(-) A-I      intronic chr17:30212552(-) A-I      intronic chr17:30191001(-) A-I      intronic chr17:30203161(-) A-I      intronic chr17:30188603(-) A-I      3'UTR chr17:30189761(-) A-I      3'UTR chr17:30188403(-) A-I      3'UTR chr17:30188389(-) A-I      3'UTR chr17:30203066(-) A-I      intronic chr17:30189070(-) A-I      3'UTR chr17:30203283(-) A-I      intronic chr17:30190896(-) A-I      intronic chr17:30196508(-) A-I      intronic chr17:30209436(-) A-I      intronic chr17:30211900(-) A-I      intronic chr17:30196280(-) A-I      intronic chr17:30189071(-) A-I      3'UTR chr17:30211916(-) A-I      intronic chr17:30208454(-) A-I      intronic chr17:30200157(-) A-I      intronic chr17:30189837(-) A-I      3'UTR chr17:30201899(-) A-I      intronic chr17:30211876(-) A-I      intronic chr17:30210614(-) A-I      intronic chr17:30216630(-) A-I      intronic chr17:30216789(-) A-I      intronic chr17:30210118(-) A-I      intronic chr17:30225525(-) A-I      intronic chr17:30199775(-) A-I      intronic chr17:30195530(-) A-I      intronic chr17:30191421(-) A-I      intronic chr17:30198678(-) A-I      intronic chr17:30189128(-) A-I      3'UTR chr17:30225487(-) A-I      intronic chr17:30217376(-) A-I      intronic chr17:30212644(-) A-I      intronic chr17:30203838(-) A-I      intronic chr17:30188175(-) A-I      3'UTR chr17:30209405(-) A-I      intronic chr17:30224197(-) A-I      intronic chr17:30212564(-) A-I      intronic chr17:30203865(-) A-I      intronic chr17:30203220(-) A-I      intronic chr17:30208138(-) A-I      intronic chr17:30189616(-) A-I      3'UTR chr17:30188464(-) A-I      3'UTR chr17:30202759(-) A-I      intronic chr17:30227080(-) A-I      intronic chr17:30227077(-) A-I      intronic chr17:30191398(-) A-I      intronic chr17:30188574(-) A-I      3'UTR chr17:30198956(-) A-I      intronic chr17:30189841(-) A-I      3'UTR chr17:30226360(-) A-I      intronic chr17:30198812(-) A-I      intronic chr17:30226930(-) A-I      intronic chr17:30203274(-) A-I      intronic chr17:30189667(-) A-I      3'UTR chr17:30197679(-) A-I      intronic chr17:30203883(-) A-I      intronic chr17:30189058(-) A-I      3'UTR chr17:30203219(-) A-I      intronic chr17:30209088(-) A-I      intronic chr17:30203868(-) A-I      intronic chr17:30203498(-) A-I      intronic chr17:30189169(-) A-I      3'UTR chr17:30223132(-) A-I      intronic chr17:30226522(-) A-I      intronic chr17:30206590(-) A-I      intronic chr17:30199427(-) A-I      intronic chr17:30209128(-) A-I      intronic chr17:30223248(-) A-I      intronic chr17:30188540(-) A-I      3'UTR chr17:30226493(-) A-I      intronic chr17:30189760(-) A-I      3'UTR chr17:30202600(-) A-I      intronic chr17:30203919(-) A-I      intronic chr17:30212301(-) A-I      intronic chr17:30208423(-) A-I      intronic chr17:30212431(-) A-I      intronic chr17:30203407(-) A-I      intronic chr17:30189688(-) A-I      3'UTR chr17:30202760(-) A-I      intronic chr17:30199657(-) A-I      intronic chr17:30188195(-) A-I      3'UTR chr17:30198340(-) A-I      intronic chr17:30188466(-) A-I      3'UTR chr17:30190142(-) A-I      3'UTR chr17:30212633(-) A-I      intronic chr17:30211925(-) A-I      intronic chr17:30209567(-) A-I      intronic chr17:30188486(-) A-I      3'UTR chr17:30212437(-) A-I      intronic chr17:30199894(-) A-I      intronic chr17:30211991(-) A-I      intronic chr17:30224738(-) A-I      intronic chr17:30203328(-) A-I      intronic chr17:30188601(-) A-I      3'UTR chr17:30189864(-) A-I      3'UTR chr17:30191733(-) A-I      intronic chr17:30189755(-) A-I      3'UTR chr17:30188174(-) A-I      3'UTR chr17:30203580(-) A-I      intronic chr17:30188415(-) A-I      3'UTR chr17:30189888(-) A-I      3'UTR chr17:30196386(-) A-I      intronic chr17:30189663(-) A-I      3'UTR chr17:30191282(-) A-I      intronic chr17:30203814(-) A-I      intronic chr17:30191323(-) A-I      intronic chr17:30203896(-) A-I      intronic chr17:30199669(-) A-I      intronic chr17:30225330(-) A-I      intronic chr17:30224637(-) A-I      intronic chr17:30203948(-) A-I      intronic chr17:30212707(-) A-I      intronic chr17:30210135(-) A-I      intronic chr17:30203083(-) A-I      intronic chr17:30191138(-) A-I      intronic chr17:30198106(-) A-I      intronic chr17:30192135(-) A-I      intronic chr17:30210896(-) A-I      intronic chr17:30212641(-) A-I      intronic chr17:30227063(-) A-I      intronic chr17:30203567(-) A-I      intronic chr17:30203968(-) A-I      intronic chr17:30199763(-) A-I      intronic chr17:30199664(-) A-I      intronic chr17:30203442(-) A-I      intronic chr17:30227000(-) A-I      intronic chr17:30203858(-) A-I      intronic chr17:30199502(-) A-I      intronic chr17:30224631(-) A-I      intronic chr17:30197949(-) A-I      intronic chr17:30203907(-) A-I      intronic chr17:30217466(-) A-I      intronic chr17:30203167(-) A-I      intronic chr17:30203230(-) A-I      intronic chr17:30226997(-) A-I      intronic chr17:30201851(-) A-I      intronic chr17:30203955(-) A-I      intronic chr17:30216654(-) A-I      intronic chr17:30203184(-) A-I      intronic chr17:30218785(-) A-I      intronic chr17:30203080(-) A-I      intronic chr17:30227035(-) A-I      intronic chr17:30206287(-) A-I      intronic chr17:30224205(-) A-I      intronic chr17:30202785(-) A-I      intronic chr17:30202832(-) A-I      intronic chr17:30217469(-) A-I      intronic chr17:30203259(-) A-I      intronic chr17:30217132(-) A-I      intronic chr17:30203233(-) A-I      intronic chr17:30217378(-) A-I      intronic chr17:30212747(-) A-I      intronic chr17:30222942(-) A-I      intronic chr17:30191770(-) A-I      intronic chr17:30202742(-) A-I      intronic chr17:30218797(-) A-I      intronic chr17:30203188(-) A-I      intronic chr17:30201785(-) A-I      intronic chr17:30212051(-) A-I      ncRNA chr17:30197814(-) A-I      intronic chr17:30197963(-) A-I      intronic chr17:30202730(-) A-I      intronic chr17:30217180(-) A-I      intronic chr17:30206333(-) A-I      intronic chr17:30196021(-) A-I      intronic chr17:30202599(-) A-I      intronic chr17:30210607(-) A-I      intronic chr17:30211907(-) A-I      intronic chr17:30217197(-) A-I      intronic chr17:30227087(-) A-I      intronic chr17:30212217(-) A-I      intronic chr17:30195650(-) A-I      intronic chr17:30222681(-) A-I      intronic chr17:30203238(-) A-I      intronic chr17:30223820(-) A-I      intronic chr17:30224536(-) A-I      intronic chr17:30203329(-) A-I      intronic chr17:30217194(-) A-I      intronic chr17:30223758(-) A-I      intronic chr17:30203216(-) A-I      intronic chr17:30203148(-) A-I      intronic chr17:30199651(-) A-I      intronic chr17:30192125(-) A-I      intronic chr17:30198270(-) A-I      intronic chr17:30203969(-) A-I      intronic chr17:30198387(-) A-I      intronic chr17:30203082(-) A-I      intronic chr17:30198147(-) A-I      intronic chr17:30222600(-) A-I      intronic chr17:30195614(-) A-I      intronic chr17:30199633(-) A-I      intronic chr17:30203887(-) A-I      intronic chr17:30224535(-) A-I      intronic chr17:30196466(-) A-I      intronic chr17:30191805(-) A-I      intronic chr17:30215631(-) A-I      intronic chr17:30203086(-) A-I      intronic chr17:30189759(-) A-I      3'UTR chr17:30189257(-) A-I      3'UTR chr17:30189728(-) A-I      3'UTR chr17:30189702(-) A-I      3'UTR chr17:30189191(-) A-I      3'UTR chr17:30189231(-) A-I      3'UTR chr17:30189687(-) A-I      3'UTR chr17:30189865(-) A-I      3'UTR chr17:30189089(-) A-I      3'UTR chr17:30188397(-) A-I      3'UTR chr17:30189729(-) A-I      3'UTR chr17:30188172(-) A-I      3'UTR chr17:30188135(-) A-I      3'UTR chr17:30189147(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UTP6	chr17:30201779(-) A-I intron -    15258596 chr17:30201785(-) A-I intron -    15258596 chr17:30201788(-) A-I intron -    15258596 chr17:30201851(-) A-I intron -    15258596 chr17:30201899(-) A-I intron -    15258596 chr17:30214399(-) A-I intron -    15342557 chr17:30214487(-) A-I intron -    15342557 chr17:30214542(-) A-I intron -    15342557 chr17:30214568(-) A-I intron -    15342557 chr17:30214572(-) A-I intron -    15342557 chr17:30214617(-) A-I intron -    15342557 chr17:30214736(-) A-I intron -    15342557 chr17:30214814(-) A-I intron -    15342557 chr17:30214817(-) A-I intron -    15342557 chr17:30214858(-) A-I intron -    15342557 chr17:30214868(-) A-I intron -    15342557 chr17:30214967(-) A-I intron -    15342557 chr17:30202759(-) A-I intron -    22327324 chr17:30202790(-) A-I intron -    22327324 chr17:30203283(-) A-I intron -    22327324 chr17:30203538(-) A-I intron -    22327324 chr17:30203887(-) A-I intron -    22327324 chr17:30203955(-) A-I intron -    22327324 chr17:30196628(-) A-G intron -    22484847 chr17:30202742(-) A-G intron -    22484847 chr17:30202759(-) A-G intron -    22484847 chr17:30202760(-) A-G intron -    22484847 chr17:30202790(-) A-G intron -    22484847 chr17:30203283(-) A-G intron -    22484847 chr17:30203814(-) A-G intron -    22484847 chr17:30203883(-) A-G intron -    22484847 chr17:30203887(-) A-G intron -    22484847 chr17:30203891(-) A-G intron -    22484847 chr17:30203948(-) A-G intron -    22484847 chr17:30203955(-) A-G intron -    22484847 chr17:30214477(-) A-G intron -    22484847 chr17:30214487(-) A-G intron -    22484847 chr17:30223758(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UTP6	chr17:30190391-30190392(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30190407-30190408(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30190470-30190471(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30190477-30190478(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30190485-30190486(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30190501-30190502(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//22608085 chr17:30192437-30192438(-) m6A CDS//exon//intron       24981863 chr17:30207233-30207234(-) m6A exon//intron       24981863 chr17:30207576-30207577(-) m6A exon//intron       24981863 chr17:30207586-30207587(-) m6A exon//intron       24981863 chr17:30207603-30207604(-) m6A CDS//exon       24981863 chr17:30207673-30207674(-) m6A CDS//exon       24981863 chr17:30207696-30207697(-) m6A CDS//exon       24981863 chr17:30228650-30228651(-) m6A 5'UTR//exon       27371828 chr17:30228657-30228658(-) m6A 5'UTR//exon       27371828 chr17:30228711-30228712(-) m6A 5'UTR//exon       24981863//27371828 chr17:30228718-30228719(-) m6A 5'UTR//exon       24981863//27371828 chr17:30228771-30228772(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UTP6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: UTP6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.