Basic Information:

  VIRBase ID:  

VHID00511995

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TMEM184C:  NM_018241     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TMEM184C
miRBase Accession/Entrez ID	MIMAT0001581	55751
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM34

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM184C	chr4:148548618(+) A-I      intronic chr4:148548567(+) A-I      intronic chr4:148548546(+) A-I      intronic chr4:148548535(+) A-I      intronic chr4:148548521(+) A-I      intronic chr4:148548490(+) A-I      intronic chr4:148544575(+) A-I      intronic chr4:148544573(+) A-I      intronic chr4:148544556(+) A-I      intronic chr4:148544436(+) A-I      intronic chr4:148563002(+) A-I      intronic chr4:148543966(+) A-I      intronic chr4:148563051(+) A-I      intronic chr4:148563490(+) A-I      intronic chr4:148564234(+) A-I      intronic chr4:148564227(+) A-I      intronic chr4:148564172(+) A-I      intronic chr4:148563575(+) A-I      intronic chr4:148563502(+) A-I      intronic chr4:148564235(+) A-I      intronic chr4:148543936(+) A-I      intronic chr4:148564240(+) A-I      intronic chr4:148544422(+) A-I      intronic chr4:148564344(+) A-I      intronic chr4:148565014(+) A-I      intronic chr4:148562917(+) A-I      intronic chr4:148564359(+) A-I      intronic chr4:148572132(+) A-I      intronic chr4:148572142(+) A-I      intronic chr4:148564364(+) A-I      intronic chr4:148562939(+) A-I      intronic chr4:148562942(+) A-I      intronic chr4:148562979(+) A-I      intronic chr4:148565000(+) A-I      intronic chr4:148564996(+) A-I      intronic chr4:148564967(+) A-I      intronic chr4:148564960(+) A-I      intronic chr4:148564888(+) A-I      intronic chr4:148564367(+) A-I      intronic chr4:148563027(+) A-I      intronic chr4:148563035(+) A-I      intronic chr4:148564338(+) A-I      intronic chr4:148562913(+) A-I      intronic chr4:148562111(+) A-I      intronic chr4:148562925(+) A-I      intronic chr4:148562103(+) A-I      intronic chr4:148549235(+) A-I      intronic chr4:148548748(+) A-I      intronic chr4:148556061(+) A-I      3'UTR chr4:148556017(+) A-I      3'UTR chr4:148556019(+) A-I      3'UTR chr4:148556058(+) A-I      3'UTR chr4:148570793(+) A-I      intronic chr4:148549254(+) A-I      intronic chr4:148548495(+) A-I      intronic chr4:148570710(+) A-I      intronic chr4:148554631(+) A-I      intronic chr4:148549199(+) A-I      intronic chr4:148570843(+) A-I      intronic chr4:148553312(+) A-I      intronic chr4:148544876(+) A-I      intronic chr4:148556007(+) A-I      3'UTR chr4:148556135(+) A-I      3'UTR chr4:148556134(+) A-I      3'UTR chr4:148556147(+) A-I      3'UTR chr4:148555893(+) A-I      3'UTR chr4:148549036(+) A-I      intronic chr4:148553075(+) A-I      intronic chr4:148570779(+) A-I      intronic chr4:148549289(+) A-I      intronic chr4:148570728(+) A-I      intronic chr4:148564161(+) A-I      intronic chr4:148564964(+) A-I      intronic chr4:148549167(+) A-I      intronic chr4:148544017(+) A-I      intronic chr4:148553076(+) A-I      intronic chr4:148570930(+) A-I      intronic chr4:148543222(+) A-I      intronic chr4:148543258(+) A-I      intronic chr4:148570876(+) A-I      intronic chr4:148570771(+) A-I      intronic chr4:148570718(+) A-I      intronic chr4:148553308(+) A-I      intronic chr4:148548635(+) A-I      intronic chr4:148554657(+) A-I      intronic chr4:148553191(+) A-I      intronic chr4:148554563(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM184C	chr4:148544876(+) A-G intron -    22484847 chr4:148548481(+) A-G intron -    22484847 chr4:148548545(+) A-G intron -    22484847 chr4:148549296(+) T-C intron -    22484847 chr4:148554657(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM184C	chr4:148538709-148538710(+) m6A 5'UTR       - chr4:148538714-148538715(+) m6A 5'UTR       22575960 chr4:148538944-148538945(+) m6A 5'UTR       24284625//24981863 chr4:148539027-148539028(+) m6A 5'UTR       24284625 chr4:148539038-148539039(+) m6A 5'UTR       24284625 chr4:148539105-148539106(+) m6A 5'UTR       24284625//24981863 chr4:148555380-148555381(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr4:148555473-148555474(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555492-148555493(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555557-148555558(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555585-148555586(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555602-148555603(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555659-148555660(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr4:148555774-148555775(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr4:148555780-148555781(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr4:148555823-148555824(+) m6A 3'UTR//intron       22608085 chr4:148555877-148555878(+) m6A 3'UTR//intron       22608085 chr4:148555894-148555895(+) m6A 3'UTR//intron       22608085 chr4:148556064-148556065(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148556180-148556181(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:148556195-148556196(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:148556279-148556280(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr4:148556313-148556314(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr4:148556844-148556845(+) m6A 3'UTR//intron       27773535 chr4:148556858-148556859(+) m6A 3'UTR//intron       27773535 chr4:148556864-148556865(+) m6A 3'UTR//intron       27773535 chr4:148556882-148556883(+) m6A 3'UTR//intron       27773535 chr4:148556922-148556923(+) m6A 3'UTR//intron       27773535 chr4:148557114-148557115(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557122-148557123(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557139-148557140(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557266-148557267(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557305-148557306(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557347-148557348(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557382-148557383(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557397-148557398(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557419-148557420(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557440-148557441(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557470-148557471(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557500-148557501(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557511-148557512(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557527-148557528(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557567-148557568(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557587-148557588(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557600-148557601(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557613-148557614(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557647-148557648(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557660-148557661(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557667-148557668(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557680-148557681(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557701-148557702(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557758-148557759(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557764-148557765(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557783-148557784(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557810-148557811(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557827-148557828(+) m6A 3'UTR//intron       24981863//22608085 chr4:148593031-148593032(+) m6A 3'UTR       24981863//22608085 chr4:148593066-148593067(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TMEM184C	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TMEM184C

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.