Detail Information

Basic Information:


  VIRBase ID:  

VHID00511503

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ZNF770:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ZNF770
miRBase
Accession/Entrez ID		 MIMAT0001581 54989
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - PRO1914

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF770
chr15:35272815(-) A-I      3'UTR
chr15:35272821(-) A-I      3'UTR
chr15:35272786(-) A-I      3'UTR
chr15:35272812(-) A-I      3'UTR
chr15:35272794(-) A-I      3'UTR
chr15:35272969(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF770
chr15:35270763-35270764(-) m6A 3'UTR       27773535
chr15:35271583-35271584(-) m6A 3'UTR       24981863
chr15:35271594-35271595(-) m6A 3'UTR       24981863
chr15:35271674-35271675(-) m6A 3'UTR       24981863
chr15:35274013-35274014(-) m6A CDS       22608085
chr15:35274069-35274070(-) m6A CDS       22608085
chr15:35274075-35274076(-) m6A CDS       22608085
chr15:35274096-35274097(-) m6A CDS       22608085
chr15:35274138-35274139(-) m6A CDS       22608085
chr15:35274159-35274160(-) m6A CDS       22608085
chr15:35274168-35274169(-) m6A CDS       22608085
chr15:35274222-35274223(-) m6A CDS       22608085
chr15:35274235-35274236(-) m6A CDS       22608085
chr15:35274319-35274320(-) m6A CDS       24981863//22608085
chr15:35274355-35274356(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274422-35274423(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274446-35274447(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274455-35274456(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274462-35274463(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274485-35274486(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274498-35274499(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274635-35274636(-) m6A CDS       24981863
chr15:35274930-35274931(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274945-35274946(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35274993-35274994(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275113-35275114(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275299-35275300(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275319-35275320(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275352-35275353(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275440-35275441(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275448-35275449(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275523-35275524(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275564-35275565(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275575-35275576(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275621-35275622(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275671-35275672(-) m6A 5'UTR       24284625//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZNF770
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZNF770

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...