Basic Information:

  VIRBase ID:  

VHID00511372

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NUP62CL:  NR_033676     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NUP62CL
miRBase Accession/Entrez ID	MIMAT0001581	54830
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUP62CL	chrX:106375786(-) A-I      intronic chrX:106377085(-) A-I      intronic chrX:106377086(-) A-I      intronic chrX:106386662(-) A-I      intronic chrX:106432981(-) A-I      intronic chrX:106375771(-) A-I      intronic chrX:106375801(-) A-I      intronic chrX:106429980(-) A-I      intronic chrX:106430028(-) A-I      intronic chrX:106375949(-) A-I      intronic chrX:106430041(-) A-I      intronic chrX:106375953(-) A-I      intronic chrX:106375942(-) A-I      intronic chrX:106435707(-) A-I      intronic chrX:106430106(-) A-I      intronic chrX:106430113(-) A-I      intronic chrX:106375863(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUP62CL	chrX:106375228(-) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUP62CL	chrX:106367045-106367046(-) m6A 3'UTR       24981863//27773535 chrX:106436266-106436267(-) m6A 5'UTR//intron       24981863 chrX:106449530-106449531(-) m6A 5'UTR       24981863 chrX:106449587-106449588(-) m6A 5'UTR       24981863 chrX:106449634-106449635(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NUP62CL	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NUP62CL

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.