Basic Information:

  VIRBase ID:  

VHID00511354

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          DYM:  NM_001374436     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	DYM
miRBase Accession/Entrez ID	MIMAT0001581	54808
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	DMC//SMC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DYM	chr18:46689801(-) A-I      intronic chr18:46845303(-) A-I      intronic chr18:46845359(-) A-I      intronic chr18:46689805(-) A-I      intronic chr18:46689827(-) A-I      intronic chr18:46845343(-) A-I      intronic chr18:46845370(-) A-I      intronic chr18:46913472(-) A-I      intronic chr18:46913485(-) A-I      intronic chr18:46913503(-) A-I      intronic chr18:46845350(-) A-I      intronic chr18:46926538(-) A-I      intronic chr18:46689821(-) A-I      intronic chr18:46968839(-) A-I      intronic chr18:46768636(-) A-I      intronic chr18:46612264(-) A-I      intronic chr18:46590094(-) A-I      intronic chr18:46573244(-) A-I      intronic chr18:46573233(-) A-I      intronic chr18:46573203(-) A-I      intronic chr18:46573078(-) A-I      intronic chr18:46573013(-) A-I      intronic chr18:46572997(-) A-I      intronic chr18:46760732(-) A-I      intronic chr18:46760719(-) A-I      intronic chr18:46760718(-) A-I      intronic chr18:46760399(-) A-I      intronic chr18:46760377(-) A-I      intronic chr18:46760271(-) A-I      intronic chr18:46759667(-) A-I      intronic chr18:46759629(-) A-I      intronic chr18:46759607(-) A-I      intronic chr18:46759568(-) A-I      intronic chr18:46758944(-) A-I      intronic chr18:46758915(-) A-I      intronic chr18:46758892(-) A-I      intronic chr18:46758891(-) A-I      intronic chr18:46758868(-) A-I      intronic chr18:46758863(-) A-I      intronic chr18:46758785(-) A-I      intronic chr18:46734398(-) A-I      intronic chr18:46734335(-) A-I      intronic chr18:46686034(-) A-I      intronic chr18:46943701(-) A-I      intronic chr18:46686008(-) A-I      intronic chr18:46943778(-) A-I      intronic chr18:46944265(-) A-I      intronic chr18:46944281(-) A-I      intronic chr18:46945488(-) A-I      intronic chr18:46968656(-) A-I      intronic chr18:46969312(-) A-I      intronic chr18:46969324(-) A-I      intronic chr18:46969338(-) A-I      intronic chr18:46917046(-) A-I      intronic chr18:46917048(-) A-I      intronic chr18:46845268(-) A-I      intronic chr18:46917054(-) A-I      intronic chr18:46926489(-) A-I      intronic chr18:46926584(-) A-I      intronic chr18:46926590(-) A-I      intronic chr18:46930502(-) A-I      intronic chr18:46930615(-) A-I      intronic chr18:46930657(-) A-I      intronic chr18:46932723(-) A-I      intronic chr18:46842614(-) A-I      intronic chr18:46844884(-) A-I      intronic chr18:46845261(-) A-I      intronic chr18:46686086(-) A-I      intronic chr18:46845319(-) A-I      intronic chr18:46842569(-) A-I      intronic chr18:46845381(-) A-I      intronic chr18:46847031(-) A-I      intronic chr18:46847102(-) A-I      intronic chr18:46847122(-) A-I      intronic chr18:46862300(-) A-I      intronic chr18:46877541(-) A-I      intronic chr18:46914464(-) A-I      intronic chr18:46914697(-) A-I      intronic chr18:46915999(-) A-I      intronic chr18:46916023(-) A-I      intronic chr18:46916031(-) A-I      intronic chr18:46916118(-) A-I      intronic chr18:46916154(-) A-I      intronic chr18:46916689(-) A-I      intronic chr18:46932809(-) A-I      intronic chr18:46932830(-) A-I      intronic chr18:46932831(-) A-I      intronic chr18:46936574(-) A-I      intronic chr18:46936607(-) A-I      intronic chr18:46941690(-) A-I      intronic chr18:46943630(-) A-I      intronic chr18:46943687(-) A-I      intronic chr18:46916753(-) A-I      intronic chr18:46916798(-) A-I      intronic chr18:46916967(-) A-I      intronic chr18:46917044(-) A-I      intronic chr18:46943695(-) A-I      intronic chr18:46943696(-) A-I      intronic chr18:46815068(-) A-I      intronic chr18:46842613(-) A-I      intronic chr18:46790030(-) A-I      intronic chr18:46790016(-) A-I      intronic chr18:46789988(-) A-I      intronic chr18:46789933(-) A-I      intronic chr18:46789617(-) A-I      intronic chr18:46789581(-) A-I      intronic chr18:46768676(-) A-I      intronic chr18:46768656(-) A-I      intronic chr18:46768614(-) A-I      intronic chr18:46941463(-) A-I      intronic chr18:46931307(-) A-I      intronic chr18:46959047(-) A-I      intronic chr18:46926488(-) A-I      intronic chr18:46759148(-) A-I      intronic chr18:46734522(-) A-I      intronic chr18:46943793(-) A-I      intronic chr18:46932685(-) A-I      intronic chr18:46845380(-) A-I      intronic chr18:46915986(-) A-I      intronic chr18:46916700(-) A-I      intronic chr18:46584867(-) A-I      intronic chr18:46943747(-) A-I      intronic chr18:46845309(-) A-I      intronic chr18:46584765(-) A-I      intronic chr18:46916705(-) A-I      intronic chr18:46759161(-) A-I      intronic chr18:46913562(-) A-I      intronic chr18:46844822(-) A-I      intronic chr18:46845299(-) A-I      intronic chr18:46759587(-) A-I      intronic chr18:46916144(-) A-I      intronic chr18:46943582(-) A-I      intronic chr18:46686001(-) A-I      intronic chr18:46732368(-) A-I      intronic chr18:46789887(-) A-I      intronic chr18:46760781(-) A-I      intronic chr18:46758812(-) A-I      intronic chr18:46941476(-) A-I      intronic chr18:46962636(-) A-I      intronic chr18:46769790(-) A-I      intronic chr18:46576625(-) A-I      intronic chr18:46758734(-) A-I      intronic chr18:46914637(-) A-I      intronic chr18:46913410(-) A-I      intronic chr18:46759139(-) A-I      intronic chr18:46647252(-) A-I      intronic chr18:46943683(-) A-I      intronic chr18:46612225(-) A-I      intronic chr18:46844910(-) A-I      intronic chr18:46917164(-) A-I      intronic chr18:46913484(-) A-I      intronic chr18:46913811(-) A-I      intronic chr18:46943657(-) A-I      intronic chr18:46913490(-) A-I      intronic chr18:46769952(-) A-I      intronic chr18:46759548(-) A-I      intronic chr18:46759688(-) A-I      intronic chr18:46916988(-) A-I      intronic chr18:46926493(-) A-I      intronic chr18:46917059(-) A-I      intronic chr18:46916534(-) A-I      intronic chr18:46768684(-) A-I      intronic chr18:46916578(-) A-I      intronic chr18:46972535(-) A-I      intronic chr18:46944330(-) A-I      intronic chr18:46916599(-) A-I      intronic chr18:46844909(-) A-I      intronic chr18:46944308(-) A-I      intronic chr18:46576553(-) A-I      intronic chr18:46789653(-) A-I      intronic chr18:46845339(-) A-I      intronic chr18:46734467(-) A-I      intronic chr18:46959060(-) A-I      intronic chr18:46916563(-) A-I      intronic chr18:46916532(-) A-I      intronic chr18:46943723(-) A-I      intronic chr18:46914615(-) A-I      intronic chr18:46758806(-) A-I      intronic chr18:46972581(-) A-I      intronic chr18:46844745(-) A-I      intronic chr18:46732416(-) A-I      intronic chr18:46910811(-) A-I      intronic chr18:46613263(-) A-I      intronic chr18:46916743(-) A-I      intronic chr18:46613327(-) A-I      intronic chr18:46916171(-) A-I      intronic chr18:46914693(-) A-I      intronic chr18:46844746(-) A-I      intronic chr18:46942221(-) A-I      intronic chr18:46959256(-) A-I      intronic chr18:46739030(-) A-I      intronic chr18:46913839(-) A-I      intronic chr18:46944318(-) A-I      intronic chr18:46760240(-) A-I      intronic chr18:46941422(-) A-I      intronic chr18:46888224(-) A-I      intronic chr18:46844825(-) A-I      intronic chr18:46941469(-) A-I      intronic chr18:46917056(-) A-I      intronic chr18:46936564(-) A-I      intronic chr18:46759577(-) A-I      intronic chr18:46732507(-) A-I      intronic chr18:46769778(-) A-I      intronic chr18:46926342(-) A-I      intronic chr18:46845308(-) A-I      intronic chr18:46888685(-) A-I      intronic chr18:46759565(-) A-I      intronic chr18:46876976(-) A-I      intronic chr18:46888233(-) A-I      intronic chr18:46916102(-) A-I      intronic chr18:46690000(-) A-I      intronic chr18:46758802(-) A-I      intronic chr18:46916117(-) A-I      intronic chr18:46790012(-) A-I      intronic chr18:46862430(-) A-I      intronic chr18:46916628(-) A-I      intronic chr18:46926512(-) A-I      intronic chr18:46959243(-) A-I      intronic chr18:46789627(-) A-I      intronic chr18:46964322(-) A-I      intronic chr18:46915978(-) A-I      intronic chr18:46759235(-) A-I      intronic chr18:46964402(-) A-I      intronic chr18:46961496(-) A-I      intronic chr18:46916094(-) A-I      intronic chr18:46936605(-) A-I      intronic chr18:46914449(-) A-I      intronic chr18:46916688(-) A-I      intronic chr18:46844796(-) A-I      intronic chr18:46943611(-) A-I      intronic chr18:46913825(-) A-I      intronic chr18:46914669(-) A-I      intronic chr18:46914534(-) A-I      intronic chr18:46888508(-) A-I      intronic chr18:46758729(-) A-I      intronic chr18:46943746(-) A-I      intronic chr18:46914480(-) A-I      intronic chr18:46910751(-) A-I      intronic chr18:46760580(-) A-I      intronic chr18:46944347(-) A-I      intronic chr18:46722547(-) A-I      intronic chr18:46914578(-) A-I      intronic chr18:46943665(-) A-I      intronic chr18:46943602(-) A-I      intronic chr18:46932695(-) A-I      intronic chr18:46760642(-) A-I      intronic chr18:46961478(-) A-I      intronic chr18:46910830(-) A-I      intronic chr18:46916548(-) A-I      intronic chr18:46583285(-) A-I      intronic chr18:46845448(-) A-I      intronic chr18:46913469(-) A-I      intronic chr18:46926599(-) A-I      intronic chr18:46844880(-) A-I      intronic chr18:46584861(-) A-I      intronic chr18:46613258(-) A-I      intronic chr18:46844868(-) A-I      intronic chr18:46945565(-) A-I      intronic chr18:46943733(-) A-I      intronic chr18:46943650(-) A-I      intronic chr18:46734280(-) A-I      intronic chr18:46914545(-) A-I      intronic chr18:46912060(-) A-I      intronic chr18:46760744(-) A-I      intronic chr18:46846913(-) A-I      intronic chr18:46789761(-) A-I      intronic chr18:46936629(-) A-I      intronic chr18:46930560(-) A-I      intronic chr18:46789975(-) A-I      intronic chr18:46946603(-) A-I      intronic chr18:46768579(-) A-I      intronic chr18:46913487(-) A-I      intronic chr18:46789907(-) A-I      intronic chr18:46769852(-) A-I      intronic chr18:46768599(-) A-I      intronic chr18:46876954(-) A-I      intronic chr18:46845335(-) A-I      intronic chr18:46912182(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DYM	chr18:46944308(-) A-I intron -    15258596 chr18:46944318(-) A-I intron -    15258596 chr18:46944330(-) A-I intron -    15258596 chr18:46916005(-) A-I intron -    22327324 chr18:46916563(-) A-I intron -    22327324 chr18:46916599(-) A-I intron -    22327324 chr18:46844870(-) A-G intron -    22484847 chr18:46844880(-) A-G intron -    22484847 chr18:46846913(-) A-G intron -    22484847 chr18:46914656(-) A-G intron -    22484847 chr18:46915975(-) A-G intron -    22484847 chr18:46915978(-) A-G intron -    22484847 chr18:46916005(-) A-G intron -    22484847 chr18:46916157(-) A-G intron -    22484847 chr18:46916171(-) A-G intron -    22484847 chr18:46916599(-) A-G intron -    22484847 chr18:46943564(-) G-T intron -    22484847 chr18:46943683(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DYM	chr18:46570400-46570401(-) m6A 3'UTR       - chr18:46570455-46570456(-) m6A 3'UTR//CDS       - chr18:46645204-46645205(-) m6A CDS       27773535 chr18:46645288-46645289(-) m6A CDS       27773535 chr18:46690114-46690115(-) m6A CDS       27773535 chr18:46812811-46812812(-) m6A CDS       27773535 chr18:46812834-46812835(-) m6A 3'UTR//CDS//exon       27773535 chr18:46812844-46812845(-) m6A 3'UTR//CDS//exon       27773535 chr18:46858347-46858348(-) m6A 3'UTR//CDS//exon//intron       27773535 chr18:46858357-46858358(-) m6A 3'UTR//CDS//exon//intron       27773535 chr18:46986899-46986900(-) m6A 5'UTR//exon//intron       27371828//27773536 chr18:46986934-46986935(-) m6A 5'UTR//exon//intron       27371828//27773536 chr18:46987114-46987115(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DYM	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: DYM

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.