Basic Information:

  VIRBase ID:  

VHID00511314

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLC35F2:  NM_017515     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLC35F2
miRBase Accession/Entrez ID	MIMAT0001581	54733
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSNOV1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35F2	chr11:107744240(-) A-I      intronic chr11:107744243(-) A-I      intronic chr11:107744275(-) A-I      intronic chr11:107744211(-) A-I      intronic chr11:107672864(-) A-I      intronic chr11:107671864(-) A-I      intronic chr11:107744207(-) A-I      intronic chr11:107744208(-) A-I      intronic chr11:107744209(-) A-I      intronic chr11:107744210(-) A-I      intronic chr11:107669680(-) A-I      intronic chr11:107666773(-) A-I      intronic chr11:107668883(-) A-I      intronic chr11:107668975(-) A-I      intronic chr11:107669636(-) A-I      intronic chr11:107669645(-) A-I      intronic chr11:107669678(-) A-I      intronic chr11:107669716(-) A-I      intronic chr11:107669780(-) A-I      intronic chr11:107670382(-) A-I      intronic chr11:107670384(-) A-I      intronic chr11:107670393(-) A-I      intronic chr11:107671722(-) A-I      intronic chr11:107671795(-) A-I      intronic chr11:107672773(-) A-I      intronic chr11:107672782(-) A-I      intronic chr11:107672877(-) A-I      intronic chr11:107677926(-) A-I      intronic chr11:107678076(-) A-I      intronic chr11:107678131(-) A-I      intronic chr11:107678169(-) A-I      intronic chr11:107678421(-) A-I      intronic chr11:107682859(-) A-I      intronic chr11:107683133(-) A-I      intronic chr11:107684544(-) A-I      intronic chr11:107684570(-) A-I      intronic chr11:107684571(-) A-I      intronic chr11:107684584(-) A-I      intronic chr11:107712710(-) A-I      intronic chr11:107684604(-) A-I      intronic chr11:107685444(-) A-I      intronic chr11:107685517(-) A-I      intronic chr11:107686025(-) A-I      intronic chr11:107686031(-) A-I      intronic chr11:107686046(-) A-I      intronic chr11:107686058(-) A-I      intronic chr11:107687097(-) A-I      intronic chr11:107687756(-) A-I      intronic chr11:107687759(-) A-I      intronic chr11:107687786(-) A-I      intronic chr11:107687878(-) A-I      intronic chr11:107670463(-) A-I      intronic chr11:107710638(-) A-I      intronic chr11:107687939(-) A-I      intronic chr11:107688543(-) A-I      intronic chr11:107688745(-) A-I      intronic chr11:107688761(-) A-I      intronic chr11:107690789(-) A-I      intronic chr11:107677989(-) A-I      intronic chr11:107690898(-) A-I      intronic chr11:107683163(-) A-I      intronic chr11:107696236(-) A-I      intronic chr11:107696362(-) A-I      intronic chr11:107697158(-) A-I      intronic chr11:107698623(-) A-I      intronic chr11:107698626(-) A-I      intronic chr11:107698631(-) A-I      intronic chr11:107702175(-) A-I      intronic chr11:107704096(-) A-I      intronic chr11:107704121(-) A-I      intronic chr11:107705289(-) A-I      intronic chr11:107705293(-) A-I      intronic chr11:107709224(-) A-I      intronic chr11:107709466(-) A-I      intronic chr11:107709548(-) A-I      intronic chr11:107709587(-) A-I      intronic chr11:107709995(-) A-I      intronic chr11:107710007(-) A-I      intronic chr11:107710024(-) A-I      intronic chr11:107710087(-) A-I      intronic chr11:107710092(-) A-I      intronic chr11:107710472(-) A-I      intronic chr11:107710490(-) A-I      intronic chr11:107710504(-) A-I      intronic chr11:107710518(-) A-I      intronic chr11:107710558(-) A-I      intronic chr11:107710583(-) A-I      intronic chr11:107710611(-) A-I      intronic chr11:107710630(-) A-I      intronic chr11:107712072(-) A-I      intronic chr11:107726667(-) A-I      intronic chr11:107712157(-) A-I      intronic chr11:107717976(-) A-I      intronic chr11:107669719(-) A-I      intronic chr11:107712167(-) A-I      intronic chr11:107712203(-) A-I      intronic chr11:107712207(-) A-I      intronic chr11:107712729(-) A-I      intronic chr11:107712730(-) A-I      intronic chr11:107712735(-) A-I      intronic chr11:107713188(-) A-I      intronic chr11:107713229(-) A-I      intronic chr11:107713378(-) A-I      intronic chr11:107713406(-) A-I      intronic chr11:107716225(-) A-I      intronic chr11:107721330(-) A-I      intronic chr11:107721331(-) A-I      intronic chr11:107721538(-) A-I      intronic chr11:107727203(-) A-I      intronic chr11:107781661(-) A-I      intronic chr11:107712206(-) A-I      intronic chr11:107663870(-) A-I      intronic chr11:107686110(-) A-I      intronic chr11:107687968(-) A-I      intronic chr11:107718004(-) A-I      intronic chr11:107694411(-) A-I      intronic chr11:107671751(-) A-I      intronic chr11:107682887(-) A-I      intronic chr11:107687988(-) A-I      intronic chr11:107669003(-) A-I      intronic chr11:107741191(-) A-I      intronic chr11:107667625(-) A-I      intronic chr11:107684483(-) A-I      intronic chr11:107712705(-) A-I      intronic chr11:107684529(-) A-I      intronic chr11:107694593(-) A-I      intronic chr11:107710540(-) A-I      intronic chr11:107697091(-) A-I      intronic chr11:107710065(-) A-I      intronic chr11:107671418(-) A-I      intronic chr11:107694591(-) A-I      intronic chr11:107709543(-) A-I      intronic chr11:107696246(-) A-I      intronic chr11:107690799(-) A-I      intronic chr11:107680276(-) A-I      intronic chr11:107717883(-) A-I      intronic chr11:107662688(-) A-I      3'UTR chr11:107662480(-) A-I      3'UTR chr11:107662593(-) A-I      3'UTR chr11:107710062(-) A-I      intronic chr11:107670522(-) A-I      intronic chr11:107670753(-) A-I      intronic chr11:107687919(-) A-I      intronic chr11:107678094(-) A-I      intronic chr11:107680282(-) A-I      intronic chr11:107745328(-) A-I      intronic chr11:107713337(-) A-I      intronic chr11:107713218(-) A-I      intronic chr11:107670419(-) A-I      intronic chr11:107702224(-) A-I      intronic chr11:107688528(-) A-I      intronic chr11:107684088(-) A-I      intronic chr11:107671914(-) A-I      intronic chr11:107713384(-) A-I      intronic chr11:107713402(-) A-I      intronic chr11:107671699(-) A-I      intronic chr11:107687091(-) A-I      intronic chr11:107667680(-) A-I      intronic chr11:107667492(-) A-I      intronic chr11:107704083(-) A-I      intronic chr11:107684610(-) A-I      intronic chr11:107699108(-) A-I      intronic chr11:107700736(-) A-I      intronic chr11:107690905(-) A-I      intronic chr11:107678568(-) A-I      intronic chr11:107678596(-) A-I      intronic chr11:107671508(-) A-I      intronic chr11:107678437(-) A-I      intronic chr11:107665055(-) A-I      intronic chr11:107684049(-) A-I      intronic chr11:107666697(-) A-I      intronic chr11:107712748(-) A-I      intronic chr11:107683162(-) A-I      intronic chr11:107684651(-) A-I      intronic chr11:107710491(-) A-I      intronic chr11:107667563(-) A-I      intronic chr11:107667671(-) A-I      intronic chr11:107700061(-) A-I      intronic chr11:107690860(-) A-I      intronic chr11:107668851(-) A-I      intronic chr11:107668211(-) A-I      intronic chr11:107671406(-) A-I      intronic chr11:107663811(-) A-I      intronic chr11:107686227(-) A-I      intronic chr11:107668222(-) A-I      intronic chr11:107677910(-) A-I      intronic chr11:107720289(-) A-I      intronic chr11:107687747(-) A-I      intronic chr11:107666772(-) A-I      intronic chr11:107696200(-) A-I      intronic chr11:107678144(-) A-I      intronic chr11:107669557(-) A-I      intronic chr11:107696213(-) A-I      intronic chr11:107663875(-) A-I      intronic chr11:107716567(-) A-I      intronic chr11:107684573(-) A-I      intronic chr11:107710658(-) A-I      intronic chr11:107668179(-) A-I      intronic chr11:107686208(-) A-I      intronic chr11:107684568(-) A-I      intronic chr11:107796254(-) A-I      intronic chr11:107668196(-) A-I      intronic chr11:107702085(-) A-I      intronic chr11:107678397(-) A-I      intronic chr11:107710452(-) A-I      intronic chr11:107671859(-) A-I      intronic chr11:107710586(-) A-I      intronic chr11:107712199(-) A-I      intronic chr11:107687256(-) A-I      intronic chr11:107717909(-) A-I      intronic chr11:107710544(-) A-I      intronic chr11:107712202(-) A-I      intronic chr11:107668167(-) A-I      intronic chr11:107713217(-) A-I      intronic chr11:107788892(-) A-I      intronic chr11:107664985(-) A-I      intronic chr11:107668838(-) A-I      intronic chr11:107685704(-) A-I      intronic chr11:107669796(-) A-I      intronic chr11:107685468(-) A-I      intronic chr11:107712740(-) A-I      intronic chr11:107712745(-) A-I      intronic chr11:107688601(-) A-I      intronic chr11:107733008(-) A-I      intronic chr11:107678123(-) A-I      intronic chr11:107741206(-) A-I      intronic chr11:107712807(-) A-I      intronic chr11:107694543(-) A-I      intronic chr11:107684555(-) A-I      intronic chr11:107694592(-) A-I      intronic chr11:107682774(-) A-I      intronic chr11:107789478(-) A-I      intronic chr11:107669750(-) A-I      intronic chr11:107665091(-) A-I      intronic chr11:107686161(-) A-I      intronic chr11:107687122(-) A-I      intronic chr11:107686201(-) A-I      intronic chr11:107709147(-) A-I      intronic chr11:107687819(-) A-I      intronic chr11:107671484(-) A-I      intronic chr11:107685471(-) A-I      intronic chr11:107688739(-) A-I      intronic chr11:107696235(-) A-I      intronic chr11:107702226(-) A-I      intronic chr11:107703358(-) A-I      intronic chr11:107713142(-) A-I      intronic chr11:107717977(-) A-I      intronic chr11:107662492(-) A-I      3'UTR chr11:107662574(-) A-I      3'UTR chr11:107662667(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC35F2	chr11:107662492(-) A-G exon 3'UTR    22484847 chr11:107670522(-) A-G intron -    22484847 chr11:107676454(-) T-C intron -    22484847 chr11:107694543(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35F2	chr11:107662963-107662964(-) m6A 3'UTR       24209618//27371828 chr11:107663026-107663027(-) m6A 3'UTR       24284625//24209618//24981863//27371828 chr11:107663044-107663045(-) m6A 3'UTR       24284625//24209618//24981863 chr11:107663085-107663086(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr11:107663121-107663122(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr11:107663153-107663154(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//22608085 chr11:107663191-107663192(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//22608085 chr11:107663198-107663199(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//22608085 chr11:107663246-107663247(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr11:107663257-107663258(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr11:107663276-107663277(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr11:107663360-107663361(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr11:107663371-107663372(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr11:107729256-107729257(-) m6A 5'UTR//intron       - chr11:107729394-107729395(-) m6A CDS       24981863//27371828//27773536 chr11:107729482-107729483(-) m6A CDS       24981863//27371828//27773536 chr11:107729540-107729541(-) m6A 5'UTR       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC35F2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC35F2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.