Basic Information:

  VIRBase ID:  

VHID00511281

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NDFIP2:  NM_001161407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NDFIP2
miRBase Accession/Entrez ID	MIMAT0001581	54602
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	N4WBP5A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NDFIP2	chr13:80111372(+) A-I      intronic chr13:80111294(+) A-I      intronic chr13:80111382(+) A-I      intronic chr13:80104472(+) A-I      intronic chr13:80111274(+) A-I      intronic chr13:80102152(+) A-I      intronic chr13:80110975(+) A-I      intronic chr13:80112812(+) A-I      intronic chr13:80111446(+) A-I      intronic chr13:80111032(+) A-I      intronic chr13:80111301(+) A-I      intronic chr13:80111430(+) A-I      intronic chr13:80102141(+) A-I      intronic chr13:80102219(+) A-I      intronic chr13:80111042(+) A-I      intronic chr13:80113268(+) A-I      intronic chr13:80120131(+) A-I      intronic chr13:80058337(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NDFIP2	chr13:80055425-80055426(+) m6A CDS       24981863 chr13:80055495-80055496(+) m6A CDS       24981863 chr13:80055582-80055583(+) m6A CDS       24981863//22575960 chr13:80055641-80055642(+) m6A CDS       24981863//22575960 chr13:80093163-80093164(+) m6A exon//intron       - chr13:80126709-80126710(+) m6A 3'UTR       27773535 chr13:80126729-80126730(+) m6A 3'UTR       27773535 chr13:80128649-80128650(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NDFIP2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NDFIP2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.