Basic Information:

  VIRBase ID:  

VHID00511278

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MXRA8:  NM_001282582     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MXRA8
miRBase Accession/Entrez ID	MIMAT0001581	54587
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASP3

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MXRA8	chr1:1288108-1288109(-) m6A 3'UTR//exon       27773535//22608085 chr1:1288185-1288186(-) m6A 3'UTR//exon       27773535 chr1:1288244-1288245(-) m6A 3'UTR//exon       24981863//27773535 chr1:1288410-1288411(-) m6A 3'UTR//exon       25456834//24981863//27773535 chr1:1288439-1288440(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535 chr1:1288540-1288541(-) m6A 3'UTR//exon       25456834//24981863//22608085 chr1:1288554-1288555(-) m6A 3'UTR//exon       25456834//24981863//22608085 chr1:1288634-1288635(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288650-1288651(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288664-1288665(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288677-1288678(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288711-1288712(-) m6A 3'UTR//CDS//exon       25456834//24981863 chr1:1289043-1289044(-) m6A exon//intron       - chr1:1289160-1289161(-) m6A exon//intron       - chr1:1289232-1289233(-) m6A CDS//exon       - chr1:1289444-1289445(-) m6A CDS//exon       - chr1:1289596-1289597(-) m6A CDS//exon       - chr1:1289658-1289659(-) m6A exon//intron       - chr1:1289696-1289697(-) m6A exon//intron       - chr1:1290131-1290132(-) m6A CDS//exon       - chr1:1290339-1290340(-) m6A CDS//exon       - chr1:1290351-1290352(-) m6A CDS//exon       - chr1:1290387-1290388(-) m6A CDS//exon       25456834 chr1:1290430-1290431(-) m6A CDS//exon       25456834 chr1:1290447-1290448(-) m6A CDS//exon       25456834 chr1:1290813-1290814(-) m6A exon//intron       24209618 chr1:1290820-1290821(-) m6A exon//intron       24209618 chr1:1290894-1290895(-) m6A CDS//intron       24209618 chr1:1290936-1290937(-) m6A CDS//intron       24209618 chr1:1290978-1290979(-) m6A CDS//intron       24209618 chr1:1291014-1291015(-) m6A CDS//intron       24209618 chr1:1291021-1291022(-) m6A CDS//intron       24209618 chr1:1293851-1293852(-) m6A CDS//intron       24209618 chr1:1293909-1293910(-) m6A 5'UTR//intron       24209618 chr1:1293926-1293927(-) m6A 5'UTR//intron       - chr1:1296657-1296658(-) m6A 5'UTR       25456834 chr1:1296947-1296948(-) m6A 5'UTR       24284625//25456834//22608085 chr1:1297081-1297082(-) m6A 5'UTR       25456834 chr1:1297102-1297103(-) m6A 5'UTR       - chr1:1297120-1297121(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MXRA8	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MXRA8

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.