Basic Information:

  VIRBase ID:  

VHID00511246

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          USP53:  NM_001389661     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	USP53
miRBase Accession/Entrez ID	MIMAT0001581	54532
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP53	chr4:120186161(+) A-I      intronic chr4:120186162(+) A-I      intronic chr4:120186169(+) A-I      intronic chr4:120186178(+) A-I      intronic chr4:120186183(+) A-I      intronic chr4:120187277(+) A-I      intronic chr4:120187317(+) A-I      intronic chr4:120187326(+) A-I      intronic chr4:120187327(+) A-I      intronic chr4:120202967(+) A-I      intronic chr4:120202968(+) A-I      intronic chr4:120202969(+) A-I      intronic chr4:120202970(+) A-I      intronic chr4:120202984(+) A-I      intronic chr4:120203006(+) A-I      intronic chr4:120203012(+) A-I      intronic chr4:120203019(+) A-I      intronic chr4:120203029(+) A-I      intronic chr4:120203032(+) A-I      intronic chr4:120148032(+) A-I      intronic chr4:120148011(+) A-I      intronic chr4:120205053(+) A-I      intronic chr4:120148738(+) A-I      intronic chr4:120146652(+) A-I      intronic chr4:120205989(+) A-I      intronic chr4:120205995(+) A-I      intronic chr4:120206029(+) A-I      intronic chr4:120202978(+) A-I      intronic chr4:120146655(+) A-I      intronic chr4:120148010(+) A-I      intronic chr4:120148038(+) A-I      intronic chr4:120148058(+) A-I      intronic chr4:120148173(+) A-I      intronic chr4:120148631(+) A-I      intronic chr4:120148638(+) A-I      intronic chr4:120148727(+) A-I      intronic chr4:120148746(+) A-I      intronic chr4:120156623(+) A-I      intronic chr4:120182276(+) A-I      intronic chr4:120182290(+) A-I      intronic chr4:120184969(+) A-I      intronic chr4:120184971(+) A-I      intronic chr4:120184972(+) A-I      intronic chr4:120185002(+) A-I      intronic chr4:120148622(+) A-I      intronic chr4:120182377(+) A-I      intronic chr4:120148625(+) A-I      intronic chr4:120148028(+) A-I      intronic chr4:120148736(+) A-I      intronic chr4:120180426(+) A-I      intronic chr4:120185140(+) A-I      intronic chr4:120148562(+) A-I      intronic chr4:120148664(+) A-I      intronic chr4:120148619(+) A-I      intronic chr4:120210043(+) A-I      intronic chr4:120185023(+) A-I      intronic chr4:120146807(+) A-I      intronic chr4:120148705(+) A-I      intronic chr4:120182299(+) A-I      intronic chr4:120148255(+) A-I      intronic chr4:120148101(+) A-I      intronic chr4:120148136(+) A-I      intronic chr4:120148252(+) A-I      intronic chr4:120148197(+) A-I      intronic chr4:120148033(+) A-I      intronic chr4:120148207(+) A-I      intronic chr4:120148628(+) A-I      intronic chr4:120148106(+) A-I      intronic chr4:120145211(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP53	chr4:120148010(+) A-I intron -    21960545 chr4:120148050(+) A-I intron -    21960545 chr4:120148052(+) A-I intron -    21960545 chr4:120148106(+) A-I intron -    21960545 chr4:120148197(+) A-I intron -    21960545 chr4:120164094(+) A-I intron -    21960545 chr4:120185765(+) A-I intron -    21960545 chr4:120185847(+) A-I intron -    21960545 chr4:120185924(+) A-I intron -    21960545 chr4:120187312(+) A-I intron -    21960545 chr4:120187318(+) A-I intron -    21960545 chr4:120187491(+) A-I intron -    21960545 chr4:120187492(+) A-I intron -    21960545 chr4:120187573(+) A-I intron -    21960545 chr4:120187576(+) A-I intron -    21960545 chr4:120187635(+) A-I intron -    21960545 chr4:120187661(+) A-I intron -    21960545 chr4:120187705(+) A-I intron -    21960545 chr4:120148052(+) A-G intron -    22484847 chr4:120148252(+) A-G intron -    22484847 chr4:120148255(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP53	chr4:120133849-120133850(+) m6A 5'UTR//exon       24981863 chr4:120133991-120133992(+) m6A 5'UTR//exon       24981863 chr4:120160454-120160455(+) Y 5'UTR//exon       26075521 chr4:120160709-120160710(+) m6A 5'UTR       26404942//22608085 chr4:120160781-120160782(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160789-120160790(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160808-120160809(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160828-120160829(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160838-120160839(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160898-120160899(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160940-120160941(+) m6A CDS       22608085 chr4:120189570-120189571(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr4:120190884-120190885(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190918-120190919(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190926-120190927(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190963-120190964(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr4:120192465-120192466(+) m6A 3'UTR//CDS//exon       27773535 chr4:120192514-120192515(+) m6A 3'UTR//CDS//exon       22608085 chr4:120192565-120192566(+) m6A 3'UTR//CDS//exon       27773535//22608085 chr4:120192696-120192697(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192726-120192727(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192756-120192757(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192769-120192770(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192782-120192783(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr4:120192823-120192824(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120192838-120192839(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120192844-120192845(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120193064-120193065(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr4:120193119-120193120(+) m6A 3'UTR//CDS//exon       24209618//24981863//26404942//27773535//22608085 chr4:120193175-120193176(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr4:120212332-120212333(+) m6A 3'UTR//CDS       24981863 chr4:120213509-120213510(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213554-120213555(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213570-120213571(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213591-120213592(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213597-120213598(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213606-120213607(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213658-120213659(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213707-120213708(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213717-120213718(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213748-120213749(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213769-120213770(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213821-120213822(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213885-120213886(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120213984-120213985(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214047-120214048(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214086-120214087(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214096-120214097(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214133-120214134(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214172-120214173(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214206-120214207(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214211-120214212(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214237-120214238(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214377-120214378(+) m6A 3'UTR       24981863//22608085 chr4:120214382-120214383(+) m6A 3'UTR       24981863//22608085 chr4:120214424-120214425(+) m6A 3'UTR       24981863//22608085 chr4:120214436-120214437(+) m6A 3'UTR       24981863//22608085 chr4:120214469-120214470(+) m6A 3'UTR       24981863//26404942//22608085 chr4:120214514-120214515(+) m6A 3'UTR       26404942 chr4:120214527-120214528(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	USP53	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: USP53

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.