Basic Information:

  VIRBase ID:  

VHID00511178

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          WNT4:  NM_030761     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	WNT4
miRBase Accession/Entrez ID	MIMAT0001581	54361
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SERKAL//WNT-4

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WNT4	chr1:22444072-22444073(-) m6A 3'UTR       25456834 chr1:22444087-22444088(-) m6A 3'UTR       25456834 chr1:22444103-22444104(-) m6A 3'UTR       25456834 chr1:22444181-22444182(-) m6A 3'UTR       25456834 chr1:22445184-22445185(-) m6A 3'UTR       25456834 chr1:22445968-22445969(-) m6A 3'UTR       25456834 chr1:22446019-22446020(-) m6A 3'UTR       25456834//24981863 chr1:22446074-22446075(-) m6A 3'UTR       25456834//24981863 chr1:22446105-22446106(-) m6A 3'UTR       25456834//24981863 chr1:22446481-22446482(-) m6A 3'UTR       - chr1:22446750-22446751(-) m6A CDS       25456834//24981863 chr1:22446792-22446793(-) m6A CDS       25456834//24981863 chr1:22453657-22453658(-) m6A 3'UTR//intron       24981863 chr1:22453675-22453676(-) m6A 3'UTR//intron       25456834//24981863 chr1:22453724-22453725(-) m6A 3'UTR//intron       25456834//24981863 chr1:22453765-22453766(-) m6A CDS//intron       25456834//24981863 chr1:22453802-22453803(-) m6A CDS//intron       25456834 chr1:22453838-22453839(-) m6A CDS//intron       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WNT4	Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: WNT4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.