Detail Information

Basic Information:


  VIRBase ID:  

VHID00511160

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           C21orf91:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p C21orf91
miRBase
Accession/Entrez ID		 MIMAT0001581 54149
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C21orf14//C21orf38//CSSG1//EURL//YG81

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR C21orf91
chr21:19178991(-) A-I      intronic
chr21:19178911(-) A-I      intronic
chr21:19178899(-) A-I      intronic
chr21:19167141(-) A-I      intronic
chr21:19167201(-) A-I      intronic
chr21:19173867(-) A-I      intronic
chr21:19173846(-) A-I      intronic
chr21:19167220(-) A-I      intronic
chr21:19167218(-) A-I      intronic
chr21:19188070(-) A-I      intronic
chr21:19178994(-) A-I      intronic
chr21:19167192(-) A-I      intronic
chr21:19167139(-) A-I      intronic
chr21:19188159(-) A-I      intronic
chr21:19188116(-) A-I      intronic
chr21:19188243(-) A-I      intronic
chr21:19188180(-) A-I      intronic
chr21:19188250(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase C21orf91
chr21:19165615-19165616(-) m6A 3'UTR       22608085
chr21:19165675-19165676(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr21:19165683-19165684(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr21:19165725-19165726(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr21:19165738-19165739(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165766-19165767(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165801-19165802(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165815-19165816(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr21:19168928-19168929(-) m6A CDS       24284625//24209618//27773535//22608085
chr21:19168958-19168959(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr21:19169049-19169050(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr21:19169056-19169057(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr21:19169218-19169219(-) m6A CDS//exon       24284625//26404942//27773535//22608085
chr21:19169278-19169279(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169300-19169301(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169353-19169354(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169383-19169384(-) m6A CDS//exon       24209618//24981863//27773535//22608085
chr21:19183720-19183721(-) m6A exon//intron       27773535//22608085
chr21:19183780-19183781(-) m6A exon//intron       27773535
chr21:19190501-19190502(-) m6A exon//intron       22608085
chr21:19190550-19190551(-) m6A CDS//exon       24981863//27371828//22608085
chr21:19190562-19190563(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19190569-19190570(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19190609-19190610(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19191196-19191197(-) m6A 5'UTR//intron       25456834//24981863//27371828//22608085
chr21:19191663-19191664(-) m6A 5'UTR//exon       25456834
chr21:19191677-19191678(-) m6A 5'UTR//exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate C21orf91
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: C21orf91

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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