Detail Information

Basic Information:


  VIRBase ID:  

VHID00511002

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SLC25A39:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SLC25A39
miRBase
Accession/Entrez ID		 MIMAT0001581 51629
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CGI-69//CGI69

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC25A39
chr17:42400419(-) A-I      intronic
chr17:42400388(-) A-I      intronic
chr17:42400412(-) A-I      intronic
chr17:42399517(-) A-I      intronic
chr17:42400484(-) A-I      intronic
chr17:42400509(-) A-I      intronic
chr17:42399509(-) A-I      intronic
chr17:42399535(-) A-I      intronic
chr17:42401148(-) A-I      intronic
chr17:42401081(-) A-I      intronic
chr17:42399615(-) A-I      intronic
chr17:42401138(-) A-I      intronic
chr17:42399357(-) A-I      intronic
chr17:42401174(-) A-I      intronic
chr17:42399492(-) A-I      intronic
chr17:42399505(-) A-I      intronic
chr17:42399400(-) A-I      intronic
chr17:42401120(-) A-I      intronic
chr17:42400563(-) A-I      intronic
chr17:42400380(-) A-I      intronic
chr17:42400473(-) A-I      intronic
chr17:42399451(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC25A39
chr17:42396999-42397000(-) m6A 3'UTR//exon       24284625//27773535
chr17:42397067-42397068(-) m6A 3'UTR//exon       24284625//27773535
chr17:42397133-42397134(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr17:42397196-42397197(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr17:42397309-42397310(-) m6A 3'UTR//exon       24284625//25456834//26404942//27773535//27773536//22575960
chr17:42397348-42397349(-) m6A 3'UTR//exon       24284625//25456834//26404942//27773536//22575960
chr17:42397387-42397388(-) m6A 3'UTR//CDS//exon       24284625//25456834//26404942//27773536//22575960
chr17:42397393-42397394(-) m6A 3'UTR//CDS//exon       24284625//25456834//26404942//27773536//22575960
chr17:42397573-42397574(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960
chr17:42397625-42397626(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960
chr17:42397640-42397641(-) m6A 3'UTR//CDS//exon       24284625//27773536//22575960
chr17:42397693-42397694(-) m6A exon//intron       27773535//22575960
chr17:42397764-42397765(-) m6A 3'UTR//CDS//exon       22575960
chr17:42398033-42398034(-) m6A 3'UTR//CDS//exon       22575960
chr17:42398038-42398039(-) m6A 3'UTR//CDS//exon       22575960
chr17:42398503-42398504(-) m6A CDS//exon//intron       24284625//22575960
chr17:42398557-42398558(-) m6A CDS//exon//intron       24284625//22575960
chr17:42398645-42398646(-) m6A exon//intron       24284625//22575960
chr17:42398671-42398672(-) m6A 3'UTR//exon//intron       24284625
chr17:42398678-42398679(-) m6A 3'UTR//exon//intron       24284625
chr17:42398749-42398750(-) m6A CDS//exon//intron       24284625
chr17:42399095-42399096(-) m6A 5'UTR//CDS//exon       24284625//27773535//22575960
chr17:42400916-42400917(-) m6A CDS//exon//intron       24284625//27773536//22575960
chr17:42400943-42400944(-) m6A 5'UTR//exon//intron       24284625//27773536//22575960
chr17:42401020-42401021(-) m6A 5'UTR//exon//intron       27773536
chr17:42401398-42401399(-) m6A exon//intron       22575960
chr17:42401471-42401472(-) m6A exon//intron       24209618//25456834//22575960
chr17:42401526-42401527(-) m6A 5'UTR//intron       24284625//24209618//25456834//22575960
chr17:42401552-42401553(-) m6A 5'UTR//intron       24284625//25456834//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SLC25A39
Chromatin K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC25A39

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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