Detail Information

Basic Information:


  VIRBase ID:  

VHID00510992

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ATP6V1H:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ATP6V1H
miRBase
Accession/Entrez ID		 MIMAT0001581 51606
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CGI-11//MSTP042//NBP1//SFD//SFDalpha//SFDbeta//VMA13

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ATP6V1H
chr8:54715757(-) A-I      intronic
chr8:54723200(-) A-I      intronic
chr8:54731545(-) A-I      intronic
chr8:54731926(-) A-I      intronic
chr8:54707205(-) A-I      intronic
chr8:54747168(-) A-I      intronic
chr8:54734097(-) A-I      intronic
chr8:54715685(-) A-I      intronic
chr8:54736129(-) A-I      intronic
chr8:54736207(-) A-I      intronic
chr8:54715723(-) A-I      intronic
chr8:54736208(-) A-I      intronic
chr8:54736209(-) A-I      intronic
chr8:54747075(-) A-I      intronic
chr8:54715734(-) A-I      intronic
chr8:54750778(-) A-I      intronic
chr8:54706354(-) A-I      intronic
chr8:54657879(-) A-I      intronic
chr8:54715731(-) A-I      intronic
chr8:54657866(-) A-I      intronic
chr8:54657874(-) A-I      intronic
chr8:54660381(-) A-I      intronic
chr8:54660496(-) A-I      intronic
chr8:54660521(-) A-I      intronic
chr8:54660534(-) A-I      intronic
chr8:54736211(-) A-I      intronic
chr8:54660636(-) A-I      intronic
chr8:54660649(-) A-I      intronic
chr8:54706273(-) A-I      intronic
chr8:54706336(-) A-I      intronic
chr8:54706351(-) A-I      intronic
chr8:54707047(-) A-I      intronic
chr8:54707050(-) A-I      intronic
chr8:54707176(-) A-I      intronic
chr8:54658953(-) A-I      intronic
chr8:54657952(-) A-I      intronic
chr8:54657944(-) A-I      intronic
chr8:54707090(-) A-I      intronic
chr8:54660228(-) A-I      intronic
chr8:54710362(-) A-I      intronic
chr8:54660264(-) A-I      intronic
chr8:54631924(-) A-I      intronic
chr8:54734093(-) A-I      intronic
chr8:54752936(-) A-I      intronic
chr8:54733115(-) A-I      intronic
chr8:54747510(-) A-I      intronic
chr8:54657710(-) A-I      intronic
chr8:54721136(-) A-I      intronic
chr8:54732032(-) A-I      intronic
chr8:54707108(-) A-I      intronic
chr8:54657861(-) A-I      intronic
chr8:54658834(-) A-I      intronic
chr8:54725501(-) A-I      intronic
chr8:54660704(-) A-I      intronic
chr8:54731962(-) A-I      intronic
chr8:54660475(-) A-I      intronic
chr8:54657783(-) A-I      intronic
chr8:54665275(-) A-I      intronic
chr8:54668851(-) A-I      intronic
chr8:54736307(-) A-I      intronic
chr8:54660606(-) A-I      intronic
chr8:54665290(-) A-I      intronic
chr8:54660481(-) A-I      intronic
chr8:54725527(-) A-I      intronic
chr8:54739263(-) A-I      intronic
chr8:54723045(-) A-I      intronic
chr8:54706421(-) A-I      intronic
chr8:54660596(-) A-I      intronic
chr8:54706281(-) A-I      intronic
chr8:54747124(-) A-I      intronic
chr8:54668769(-) A-I      intronic
chr8:54660482(-) A-I      intronic
chr8:54677878(-) A-I      intronic
chr8:54657758(-) A-I      intronic
chr8:54731510(-) A-I      intronic
chr8:54665293(-) A-I      intronic
chr8:54705981(-) A-I      intronic
chr8:54706399(-) A-I      intronic
chr8:54660267(-) A-I      intronic
chr8:54736197(-) A-I      intronic
chr8:54657698(-) A-I      intronic
chr8:54660679(-) A-I      intronic
chr8:54660316(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ATP6V1H
chr8:54731962(-) A-I intron -    15545495
chr8:54731980(-) A-I intron -    15545495
chr8:54732032(-) A-I intron -    15545495
chr8:54732189(-) A-I intron -    15545495
chr8:54660596(-) A-G intron -    22484847
chr8:54660606(-) A-G intron -    22484847
chr8:54660655(-) A-G intron -    22484847
chr8:54660679(-) A-G intron -    22484847
chr8:54660704(-) A-G intron -    22484847
chr8:54706281(-) A-G intron -    22484847
chr8:54706282(-) A-G intron -    22484847
chr8:54706399(-) A-G intron -    22484847
chr8:54706416(-) A-G intron -    22484847
chr8:54706421(-) A-G intron -    22484847
chr8:54721360(-) G-T intron -    22484847
chr8:54736197(-) A-G intron -    22484847
chr8:54747124(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ATP6V1H
chr8:54755713-54755714(-) m6A 5'UTR//exon       24284625//24981863//22575960
chr8:54755721-54755722(-) m6A 5'UTR//exon       24284625//24981863//22575960
chr8:54755765-54755766(-) m6A 5'UTR//exon       24284625//24981863//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ATP6V1H
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ATP6V1H

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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