Basic Information:

  VIRBase ID:  

VHID00510947

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GSKIP:  NM_001271905     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GSKIP
miRBase Accession/Entrez ID	MIMAT0001581	51527
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf129//HSPC210

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GSKIP	chr14:96829823-96829824(+) m1A 5'UTR       26863410 chr14:96829884-96829885(+) m1A 5'UTR//exon       26863196//26863410 chr14:96830369-96830370(+) m6A 5'UTR//intron       25456834 chr14:96830443-96830444(+) m6A 5'UTR//intron       24209618 chr14:96830456-96830457(+) m6A 5'UTR//intron       24209618 chr14:96830759-96830760(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830765-96830766(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830778-96830779(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830899-96830900(+) m6A 5'UTR//intron       24284625//22608085 chr14:96830940-96830941(+) m6A 5'UTR//intron       - chr14:96830996-96830997(+) m6A 5'UTR//intron       24981863 chr14:96831097-96831098(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831119-96831120(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831204-96831205(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr14:96831311-96831312(+) m6A 5'UTR//intron       22608085 chr14:96831324-96831325(+) m6A 5'UTR//intron       22608085 chr14:96845319-96845320(+) m6A 5'UTR//intron       24981863 chr14:96845346-96845347(+) m6A 5'UTR//intron       24981863 chr14:96848590-96848591(+) m6A CDS       25456834//24981863//22608085 chr14:96848665-96848666(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848678-96848679(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848791-96848792(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848804-96848805(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848820-96848821(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851050-96851051(+) Y intron       25219674 chr14:96851901-96851902(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851916-96851917(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851987-96851988(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr14:96852011-96852012(+) m6A CDS       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GSKIP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GSKIP

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.