Basic Information:

  VIRBase ID:  

VHID00510899

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SUCO:  NM_016227     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SUCO
miRBase Accession/Entrez ID	MIMAT0001581	51430
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf9//CH1//OPT//SLP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SUCO	chr1:172515215(+) A-I      intronic chr1:172515991(+) A-I      intronic chr1:172515188(+) A-I      intronic chr1:172515902(+) A-I      intronic chr1:172515873(+) A-I      intronic chr1:172515848(+) A-I      intronic chr1:172515934(+) A-I      intronic chr1:172550088(+) A-I      intronic chr1:172515878(+) A-I      intronic chr1:172515969(+) A-I      intronic chr1:172515151(+) A-I      intronic chr1:172515889(+) A-I      intronic chr1:172570554(+) A-I      intronic chr1:172515928(+) A-I      intronic chr1:172553674(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SUCO	chr1:172501746-172501747(+) m6A CDS       27773535 chr1:172501766-172501767(+) m6A CDS       27773535 chr1:172501813-172501814(+) m6A CDS       27773535 chr1:172502464-172502465(+) m6A 5'UTR//CDS       - chr1:172558040-172558041(+) m6A CDS       24981863//22608085 chr1:172558077-172558078(+) m6A CDS//intron       24981863//22608085 chr1:172558097-172558098(+) m6A CDS//intron       24981863//22608085 chr1:172558188-172558189(+) m6A CDS//intron       24981863//22608085 chr1:172558326-172558327(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr1:172558400-172558401(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558406-172558407(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558422-172558423(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558514-172558515(+) m6A CDS//intron       24284625//24981863//22608085 chr1:172558569-172558570(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558574-172558575(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558607-172558608(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558626-172558627(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558675-172558676(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr1:172558707-172558708(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr1:172558794-172558795(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22608085 chr1:172558847-172558848(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr1:172558887-172558888(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr1:172558966-172558967(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr1:172558991-172558992(+) m6A CDS//intron       24981863//22608085 chr1:172559047-172559048(+) Y CDS//intron       26075521 chr1:172577914-172577915(+) m6A CDS//exon       22608085 chr1:172578991-172578992(+) m6A CDS//exon       22608085 chr1:172579008-172579009(+) m6A CDS//exon       22608085 chr1:172579061-172579062(+) m6A CDS//exon       24284625//24981863//22608085 chr1:172579138-172579139(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr1:172579203-172579204(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579216-172579217(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579222-172579223(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579265-172579266(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579285-172579286(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579297-172579298(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579343-172579344(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579363-172579364(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579389-172579390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579409-172579410(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579425-172579426(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:172579451-172579452(+) m6A 3'UTR       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SUCO	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SUCO

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.