Detail Information

Basic Information:


  VIRBase ID:  

VHID00510809

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ERGIC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ERGIC2
miRBase
Accession/Entrez ID		 MIMAT0001581 51290
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - cd002//CDA14//Erv41//PTX1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ERGIC2
chr12:29499291(-) A-I      intronic
chr12:29495219(-) A-I      intronic
chr12:29499290(-) A-I      intronic
chr12:29498626(-) A-I      intronic
chr12:29495173(-) A-I      intronic
chr12:29525869(-) A-I      intronic
chr12:29525789(-) A-I      intronic
chr12:29525600(-) A-I      intronic
chr12:29509138(-) A-I      intronic
chr12:29509135(-) A-I      intronic
chr12:29509131(-) A-I      intronic
chr12:29509092(-) A-I      intronic
chr12:29505616(-) A-I      intronic
chr12:29505514(-) A-I      intronic
chr12:29505461(-) A-I      intronic
chr12:29505439(-) A-I      intronic
chr12:29505430(-) A-I      intronic
chr12:29505370(-) A-I      intronic
chr12:29499396(-) A-I      intronic
chr12:29499194(-) A-I      intronic
chr12:29525200(-) A-I      intronic
chr12:29499260(-) A-I      intronic
chr12:29509052(-) A-I      intronic
chr12:29499250(-) A-I      intronic
chr12:29499285(-) A-I      intronic
chr12:29498629(-) A-I      intronic
chr12:29505448(-) A-I      intronic
chr12:29495006(-) A-I      intronic
chr12:29505564(-) A-I      intronic
chr12:29499187(-) A-I      intronic
chr12:29499398(-) A-I      intronic
chr12:29498713(-) A-I      intronic
chr12:29499289(-) A-I      intronic
chr12:29499350(-) A-I      intronic
chr12:29505555(-) A-I      intronic
chr12:29505561(-) A-I      intronic
chr12:29498709(-) A-I      intronic
chr12:29505458(-) A-I      intronic
chr12:29499246(-) A-I      intronic
chr12:29498707(-) A-I      intronic
chr12:29505521(-) A-I      intronic
chr12:29498602(-) A-I      intronic
chr12:29494533(-) A-I      intronic
chr12:29505433(-) A-I      intronic
chr12:29509134(-) A-I      intronic
chr12:29498590(-) A-I      intronic
chr12:29525729(-) A-I      intronic
chr12:29498731(-) A-I      intronic
chr12:29525848(-) A-I      intronic
chr12:29525625(-) A-I      intronic
chr12:29495109(-) A-I      intronic
chr12:29509175(-) A-I      intronic
chr12:29494468(-) A-I      intronic
chr12:29509119(-) A-I      intronic
chr12:29499299(-) A-I      intronic
chr12:29505475(-) A-I      intronic
chr12:29509047(-) A-I      intronic
chr12:29498833(-) A-I      intronic
chr12:29498730(-) A-I      intronic
chr12:29498839(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ERGIC2
chr12:29493734(-) A-I exon 3'UTR    22327324
chr12:29495109(-) A-G intron -    22484847
chr12:29498602(-) A-G intron -    22484847
chr12:29498707(-) A-G intron -    22484847
chr12:29498730(-) A-G intron -    22484847
chr12:29498839(-) A-G intron -    22484847
chr12:29499246(-) A-G intron -    22484847
chr12:29499260(-) A-G intron -    22484847
chr12:29499285(-) A-G intron -    22484847
chr12:29499289(-) A-G intron -    22484847
chr12:29499350(-) A-G intron -    22484847
chr12:29499398(-) A-G intron -    22484847
chr12:29505433(-) A-G intron -    22484847
chr12:29505448(-) A-G intron -    22484847
chr12:29505458(-) A-G intron -    22484847
chr12:29505521(-) A-G intron -    22484847
chr12:29505561(-) A-G intron -    22484847
chr12:29509047(-) A-G intron -    22484847
chr12:29525200(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ERGIC2
chr12:29492215-29492216(-) m6A 3'UTR       27773535
chr12:29492238-29492239(-) m6A 3'UTR       27773535
chr12:29492280-29492281(-) m6A 3'UTR       27773535
chr12:29492666-29492667(-) m6A 3'UTR       27773535
chr12:29492675-29492676(-) m6A 3'UTR       27773535
chr12:29492734-29492735(-) m6A 3'UTR       27773535
chr12:29492762-29492763(-) m6A 3'UTR       27773535
chr12:29492770-29492771(-) m6A 3'UTR       27773535
chr12:29492794-29492795(-) m6A 3'UTR       27773535
chr12:29493631-29493632(-) m6A 3'UTR       27773535
chr12:29493641-29493642(-) m6A 3'UTR       27773535
chr12:29493652-29493653(-) m6A 3'UTR       27773535
chr12:29493722-29493723(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493746-29493747(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493789-29493790(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493933-29493934(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493939-29493940(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493977-29493978(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29493994-29493995(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494043-29494044(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494050-29494051(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494064-29494065(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494125-29494126(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494678-29494679(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494693-29494694(-) m6A 3'UTR//CDS//exon       27773535
chr12:29494766-29494767(-) m6A exon//intron       27773535
chr12:29534033-29534034(-) m6A 5'UTR//intron       24981863
chr12:29534059-29534060(-) m6A 5'UTR       24981863
chr12:29534077-29534078(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ERGIC2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ERGIC2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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